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Study shows the benefits of locally administered intranasal live-attenuated SARS-CoV-2 vaccine

Rocketvax AG, together with the German Research Foundation (DFG), has financially supported a study carried out as part of a joint project of the Swiss National Science Foundation (SNSF, National Research Program "Covid-19," NRP 78) and the German Research Foundation (DFG) "Recoding the SARS-CoV-2 Genome - A Multidisciplinary Approach to Generate Live-Attenuated Coronavirus Vaccines."

27 Feb 2024

Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.

9 Jan 2024

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

Researchers investigated the Role of Cylicins in Spermiogenesis and Male Fertility in Mice and Humans through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) Gene Editing.

30 Nov 2023

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

Researchers described an approach to edit the recombination-activating gene 2 (RAG2) locus for therapeutic applications.

1 Nov 2023

Unsupervised genome-wide variant effect predictor based on pretraining of DNA language models

The Genomic Pre-trained Network (GPN), a multispecies model developed to learn genome-wide variant effects.

31 Oct 2023

Study reveals unexpected variation in genetic code of protist

Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics.

6 Oct 2023

Start Codon invites life sciences leaders, founders, and investors to Innovation Showcase 2023

Start Codon is pleased to invite life sciences people from across the life science and biotech industries to attend their Innovation Showcase 2023.

From Start Codon Ltd 2 Oct 2023

ELRIG UK announces the formation of Engagement Strategy Work Group

The European Laboratory Research & Innovation Group (ELRIG) UK today announced the formation of its Engagement Strategy Work Group (ESWG). The group will provide strategic direction and guidance to help ensure the ELRIG community continues to grow and thrive.

15 Sep 2023

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.

14 Sep 2023

Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies

Researchers used a SARS-CoV-2 spike protein-pseudotyped viral model to characterize BA.2.86 variant neutralization by monoclonal antibodies.

6 Sep 2023

Novel algorithm characterizes RNA motifs in SARS-CoV and SARS-CoV-2

Researchers developed a novel algorithm to analyze large genomic datasets of RNA viruses, applying it to SARS-CoV-2 and SARS-CoV.

1 Aug 2023

Mutational accessibility: A key driver of viral evolution

The influenza (flu) virus is constantly undergoing a process of evolution and adaptation through acquiring new mutations.

29 Jul 2023

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

NK:IO raises £1.2M, bringing total Seed funding to £5.1M, to advance pioneering NK cell therapy

New investment of £1.2M brings total Seed funding to £5.1M including Innovate UK grants of £1.9M.

From NK:IO Limited 25 Jul 2023

Difficult transmembrane protein targets for therapeutic antibodies

In this interview, News-Medical talks to Sylvia Xie, product scientist at Sino Biological, about the ongoing emergence of transmembrane proteins as targets for therapeutic antibodies.

From Sino Biological Inc. 12 Jul 2023

Artificial viral vectors constructed from bacteriophage T4 show promise for advanced gene delivery

Research presents an assembly-line approach using bacteriophage T4 components to construct artificial viral vectors (AVVs). These AVVs have the potential to revolutionize gene therapies and personalized medicine by enabling the efficient delivery of biomolecules for molecular repairs and genome remodeling.

1 Jun 2023

The adaptive immunity of human endemic viruses

Researchers studied the evolution of the ability of viruses to evade the neutralizing antibodies.

24 May 2023

Reviving a forgotten antibiotic: Old drug shows new promise against superbugs

Research discusses the activity spectrum of nourseothricin and its components, S-F and S-D, against drug-resistant, gram-negative pathogens. S-F showed promising activity against NDM-1-expressing Klebsiella pneumoniae Nevada strain with minimal toxicity, and it probes the A-decoding site potentially accounting for its miscoding activity.

17 May 2023

Schlafen 12 identified as a novel HIV restriction factor

An international study led by MELIS-UPF researchers from the Infection Biology and Molecular Virology laboratories has identified and characterized Schlafen 12 (SLFN 12) as a novel HIV restriction factor.

10 May 2023

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

Research paper proposes a new method for predicting highly expressed genes based on codon usage bias and minimum free energy of mRNA secondary structures. The method involves constructing a stochastic grammar that generates sequences with high CAI and low MFE, and testing it on two mRNA vaccines.

3 May 2023