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Every year, about one million new cases of colon cancer are diagnosed worldwide. About 150,000 new cases are detected each year in the United States. Over a lifetime, about 1 in 19 people develop colon cancer and nearly 50,000 people are expected to die from it in the U.S. this year. According to the American Cancer Society, colon cancer is the third leading cause of cancer-related death in the U.S., accounting for about 10 percent of all cancer deaths.
Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

The formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated. [More]
Salmonella protein can reduce drug resistant molecule found in cancer cells

Salmonella protein can reduce drug resistant molecule found in cancer cells

A surprising result in an experiment on Salmonella bacteria has led to a discovery that may make drug resistant cancer cells more treatable by conventional chemotherapies. [More]
Combination of two plant compounds holds promise in treating colon cancer

Combination of two plant compounds holds promise in treating colon cancer

The combination of two plant compounds that have medicinal properties - curcumin and silymarin - holds promise in treating colon cancer, according Saint Louis University research published in the June 23 issue of the Journal of Cancer. [More]
Study uncovers new drug-gene mutation combinations that can kill cancer cells

Study uncovers new drug-gene mutation combinations that can kill cancer cells

In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. [More]
Researchers developing and validating model to predict risk for colon cancer in people under 50

Researchers developing and validating model to predict risk for colon cancer in people under 50

While the incidence of colon cancer has been declining in individuals 50 years old and older in the United States, it is steadily rising in those under age 50. With funding from the U.S. Department of Veterans Affairs, Thomas F. Imperiale, M.D., a VA and Regenstrief Institute clinician-researcher, is developing and validating a model to predict risk for colon cancer in those under 50 with no family history of the disease. [More]
Researchers identify unique mechanism to suppress colorectal cancer tumors in mice

Researchers identify unique mechanism to suppress colorectal cancer tumors in mice

A new scientific study has identified why colorectal cancer cells depend on a specific nutrient, and a way to starve them of it. Over one million men and women are living with colorectal cancer in the United States. [More]
Adjuvant chemotherapy may improve survival in stage 2 colon cancer patients

Adjuvant chemotherapy may improve survival in stage 2 colon cancer patients

Researchers and physicians have grappled with the role of "adjuvant," or post-surgery, chemotherapy for patients with early-stage colon cancer, even for cancers considered high risk. [More]
Gut microbiota could influence person's likelihood of developing colon cancer

Gut microbiota could influence person's likelihood of developing colon cancer

The microscopic organisms that live in our gut do more than help us digest food. A new study in rats bolsters a growing body of evidence that the complex mix of microorganisms found in the gut, known as gut microbiota, could influence a person's likelihood of developing colon cancer. [More]
Pancreatic cysts increase overall risk of pancreatic cancer, study shows

Pancreatic cysts increase overall risk of pancreatic cancer, study shows

A look back at more than half a million patient records has established that patients with pancreatic cysts have a significantly higher overall risk of pancreatic cancer compared to those without such cysts, according to a study in the July issue of GIE: Gastrointestinal Endoscopy, the journal of the American Society for Gastrointestinal Endoscopy. [More]
Recellularized colon model helps identify cancer driver genes involved in CRC progression

Recellularized colon model helps identify cancer driver genes involved in CRC progression

Genetic mutations are a major cause of cancer, and tracking the role of each gene in cancer pathogenesis has long been an important tool in the fight against a disease that is expected to kill more than 1.6 million people this year. [More]
Tumor DNA fragments in blood can help identify risk of colorectal cancer recurrence

Tumor DNA fragments in blood can help identify risk of colorectal cancer recurrence

Ludwig researchers working in collaboration with colleagues in Australia and the US have shown that fragments of tumor DNA circulating in the blood can be used to gauge the risk of colorectal cancer recurrence and the efficacy of chemotherapy following surgery. [More]
Mitochondrial stress can trigger tumor-related metabolic shifts, study finds

Mitochondrial stress can trigger tumor-related metabolic shifts, study finds

Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts that enable a tumor's rapid growth. [More]
New ESMO guidelines reflect personalized approach for management of metastatic colorectal cancer

New ESMO guidelines reflect personalized approach for management of metastatic colorectal cancer

ESMO, the leading European professional organisation for medical oncology, has released new consensus guidelines for the management of metastatic colorectal cancer that reflect an increasingly personalized approach to treatment, as published online today in Annals of Oncology. [More]
Genetic test detects colon cancer-linked DNA in blood to predict disease recurrence risk

Genetic test detects colon cancer-linked DNA in blood to predict disease recurrence risk

Scientists at the Johns Hopkins Kimmel Cancer Center and University of Melbourne report they have used a genetic test that spots bits of cancer-related DNA circulating in the blood to accurately predict the likelihood of the disease's return in some — but not all — of a small group of patients with early-stage colon cancer. [More]
TAILOR study shows treatment with Erbitux plus FOLFOX improves survival in RAS wild-type mCRC patients

TAILOR study shows treatment with Erbitux plus FOLFOX improves survival in RAS wild-type mCRC patients

Merck, a leading science and technology company, will present data at the ESMO 18th World Congress on Gastrointestinal Cancer from the pivotal Phase III TAILOR study in patients from China, the first prospective trial to evaluate an anti-EGFR antibody in the first-line therapy of patients with RAS wild-type metastatic colorectal cancer (mCRC). [More]
Enzyme from fermented Japanese vegetable boosts colon health in rats

Enzyme from fermented Japanese vegetable boosts colon health in rats

An enzyme produced by fermenting a vegetable common in Japanese cuisine may be responsible for increasing the amount of at least one beneficial bacterium associated with healthy colons in a study using rats. [More]
Researcher identifies how Itch protein inhibits colonic inflammation and carcinogenesis

Researcher identifies how Itch protein inhibits colonic inflammation and carcinogenesis

Venuprasad Poojary, PhD, an associate investigator at Baylor Institute for Immunology Research (BIIR), part of Baylor Scott & White Research Institute, reported this week in the journal Nature Immunology the role of a key protein in the regulatory pathway that is involved in limiting colon inflammation and tumor growth. [More]
Researchers develop new computational method to track colorectal cancer progression

Researchers develop new computational method to track colorectal cancer progression

Team of researchers elaborated a computational method to track the progress of the colorectal cancer. It is a scientific advance that can bring new perspectives to discover the factors that push this pathology and the selection of efficient therapies. [More]
Primary care visits lead to more screenings and follow-up colonoscopies

Primary care visits lead to more screenings and follow-up colonoscopies

People who visit their primary care physicians are more likely to get potentially life-saving colon cancer screenings and follow up on abnormal stool blood test results - even in health systems that heavily promote mail-in home stool blood tests that don't require a doctor visit, a study involving UT Southwestern population health researchers shows. [More]
Siemens Healthineers' new CT and MRI technologies to aid research across various common clinical pathways

Siemens Healthineers' new CT and MRI technologies to aid research across various common clinical pathways

The Transforming Outcomes and Health Economics Through Imaging (TOHETI) programme is looking to change the way medical imaging works by undertaking a range of pioneering research. [More]
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