Corticosteroid News and Research

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Corticosteroids are any steroid hormones made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias.

NAVIGATOR trial: Nearly half of asthma patients improved with tezepelumab treatment

A greater proportion of patients with severe, uncontrolled asthma had more significant clinical responses to tezepelumab than placebo, according to research published at the ATS 2022 international conference.

16 May 2022

Study supports daily steroid doses for children with Duchenne muscular dystrophy

New research published in JAMA recommends daily steroid doses for children with Duchenne muscular dystrophy (DMD), marking a significant change in how the disease is treated.

4 May 2022

Poor asthma control triggered by SARS-CoV-2

In a new study, researchers noted that COVID-19 could trigger poor pediatric asthma control.

29 Apr 2022

Corticosteroid exposure associated with hospitalization for severe pain event among patients with sickle cell disease

People with sickle cell disease (SCD) who were recently prescribed a corticosteroid – a medicine frequently used to treat asthma or inflammation – were found to be significantly more likely to be hospitalized for a severe pain event, according to a paper published today in the journal Blood.

27 Apr 2022

Interleukin-3 may contribute to alleviating asthma, research suggests

The messenger substance interleukin-3 produced by the body was previously considered to be pro-inflammatory in bronchial asthma.

21 Apr 2022

Effects of COVID-19 treatment best with combination therapy

There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

15 Apr 2022

Study evaluates efficacy of sarilumab in severe/critical COVID-19 patients

Researchers discuss the results of a clinical trial to assess the efficacy and safety of IV sarilumab for the treatment of hospitalized COVID-19 patients.

27 Mar 2022

Covid-19 patients are at increased risk of developing type 2 diabetes, study shows

People who have had Covid-19 are at increased risk of developing type 2 diabetes. This is the result of a study by DDZ, DZD and IQVIA, which has now been published in Diabetologia.

21 Mar 2022

Metabolomic profiling reveals adrenal suppression due to inhaled corticosteroid treatment for asthma

Inhaled cortical steroids (ICS) can help patients manage asthma symptoms, and recent updates to asthma treatment guidelines have expanded recommended, low-dose treatment.

21 Mar 2022

Biological timeline of COVID-19 immune recovery described in new research

In a recent study published on the bioRxiv* preprint server, a group of researchers from the University of California, San Francisco, looked at intra-patient immunological changes over time to see if there were any changes in immune responses associated with successful COVID-19 resolution.

21 Mar 2022

White blood cell count as a prognostic indicator of COVID-19

Based on a new study, researchers concluded WBC count variations worsen clinical outcomes such as severity, mortality, and hospital discharge rates leading to a poorer prognosis in COVID-19 patients.

23 Feb 2022

Evaluating the use of megadoses of corticosteroids as a treatment of COVID-19

In a new study, researchers have been investigating the effects of megadoses of corticosteroids on hospitalized COVID-19 patients.

26 Jan 2022

Early-life smoke exposure produces long-lasting sleep alterations in adult mice

Researchers of the University of Bologna carried out a study on murine models (mice) demonstrating that pre-natal exposure to nicotine and its by-products produces long-term effects on sleep and stress-response in some areas of the brain.

24 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

A nematode infection can become severe and deadly with the use of corticosteroids

Healthcare workers in tropical and sub-tropical settings where strongyloidiasis is prevalent or caring for patients who have travelled to such areas, need to maintain a high level of awareness about the use of corticosteroids, including when this class of anti-inflammatories is given to patients suspected of infection with SARS-CoV-2.

19 Dec 2021

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

The combination of dasatinib, blinatumomab, and prednisone can be effective in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are not good candidates for intensive chemotherapy treatment.

13 Dec 2021

New consensus-based recommendations designed to improve quality of life for DMD patients

Many more adults with Duchenne muscular dystrophy (DMD) are living longer thanks to improvements in treatment, however international standards of care have not yet fully addressed the complex needs of these patients.

9 Dec 2021

Does SARS-CoV-2 infection contribute to adrenal gland dysfunction?

New research suggests that SARS-CoV-2 infection can directly target and cause cellular damage to the adrenal glands.

23 Nov 2021

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

Combination treatment improves overall survival for melanoma patients with brain metastases

Combination treatment with immune checkpoint inhibitors nivolumab and ipilimumab demonstrates overall survival for patients with melanoma that has spread to the brain, according to Phase II study results published today in The Lancet Oncology by researchers from The University of Texas MD Anderson Cancer Center.

11 Nov 2021

Corticosteroid News and Research

NAVIGATOR trial: Nearly half of asthma patients improved with tezepelumab treatment

Study supports daily steroid doses for children with Duchenne muscular dystrophy

Poor asthma control triggered by SARS-CoV-2

Corticosteroid exposure associated with hospitalization for severe pain event among patients with sickle cell disease

Interleukin-3 may contribute to alleviating asthma, research suggests

Effects of COVID-19 treatment best with combination therapy

Study evaluates efficacy of sarilumab in severe/critical COVID-19 patients

Covid-19 patients are at increased risk of developing type 2 diabetes, study shows

Metabolomic profiling reveals adrenal suppression due to inhaled corticosteroid treatment for asthma

Biological timeline of COVID-19 immune recovery described in new research

White blood cell count as a prognostic indicator of COVID-19

Evaluating the use of megadoses of corticosteroids as a treatment of COVID-19

Early-life smoke exposure produces long-lasting sleep alterations in adult mice

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

A nematode infection can become severe and deadly with the use of corticosteroids

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

New consensus-based recommendations designed to improve quality of life for DMD patients

Does SARS-CoV-2 infection contribute to adrenal gland dysfunction?

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

Combination treatment improves overall survival for melanoma patients with brain metastases

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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