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Phase 2 RESONATE-17 study: IMBRUVICA (ibrutinib) improves survival in CLL patients with del 17p

Phase 2 RESONATE-17 study: IMBRUVICA (ibrutinib) improves survival in CLL patients with del 17p

Results from the Phase 2 RESONATE-17 (PCYC-1117) study show IMBRUVICA (ibrutinib) was associated with an 82.6 percent investigator-assessed overall response rate (ORR; the primary endpoint) and a 79 percent progression-free survival (PFS) rate at 12 months in people living with relapsed/refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have a genetic mutation known as deletion 17p (del 17p). [More]
Vitamin C may reduce exercise-induced bronchoconstriction and respiratory symptoms

Vitamin C may reduce exercise-induced bronchoconstriction and respiratory symptoms

Physical activity increases oxidative stress, and therefore, as an antioxidant vitamin C might have particularly evident effects on people who are participating in vigorous exercise. In several studies, vitamin C administration attenuated the increases in oxidative stress markers caused by exercise. Furthermore, vitamin C is involved in the metabolism of histamine, prostaglandins, and cysteinyl leukotrienes, all of which appear to be mediators in the pathogenesis of exercise-induced bronchoconstriction. [More]
New diagnostic system describes symptoms using the image of patient's tongue

New diagnostic system describes symptoms using the image of patient's tongue

Physicians often ask their patients to "Please stick out your tongue". The tongue can betray signs of illness, which combined with other symptoms such as a cough, fever, presence of jaundice, headache or bowel habits, can help the physician offer a diagnosis. For people in remote areas who do not have ready access to a physician, a new diagnostic system is reported in the International Journal of Biomedical Engineering and Technology that works to combine the soft inputs of described symptoms with a digital analysis of an image of the patient's tongue. [More]
Mylan gets tentative approval from FDA for two pediatric dosages of abacavir/lamivudine tablets

Mylan gets tentative approval from FDA for two pediatric dosages of abacavir/lamivudine tablets

Mylan Inc. today announced that its subsidiary Mylan Laboratories Limited has received tentative approval from the U.S. Food and Drug Administration for its New Drug Applications (NDAs) for two dosages of abacavir/lamivudine tablets for oral suspension for the treatment of HIV-1 infection in pediatric patients. [More]
Many pediatric chest X-rays unnecessary, offer no clinical benefit

Many pediatric chest X-rays unnecessary, offer no clinical benefit

Researchers at Mayo Clinic found that some children are receiving chest X-rays that may be unnecessary and offer no clinical benefit to the patient, according to a study presented today at the annual meeting of the Radiological Society of North America. [More]
Baxter seeks FDA approval of BAX 855 for treatment of people with hemophilia A

Baxter seeks FDA approval of BAX 855 for treatment of people with hemophilia A

Nektar Therapeutics reported that partner Baxter International Inc. today announced that the company has submitted a biologics license application (BLA) to the United States Food and Drug Administration for the approval of BAX 855, an investigational, extended half-life recombinant factor VIII (rFVIII) treatment for hemophilia A based on ADVATE [Antihemophilic Factor (Recombinant)]. [More]
No survival benefit with dacomitinib in pretreated patients with advanced NSCLC

No survival benefit with dacomitinib in pretreated patients with advanced NSCLC

The irreversible, pan-epidermal growth factor receptor tyrosine kinase inhibitor dacomitinib does not offer a survival benefit in pretreated patients with advanced or metastatic non-small-cell lung cancer, phase III trial results show. [More]
Community pharmacies can help identify COPD at early stage, save £264 million

Community pharmacies can help identify COPD at early stage, save £264 million

Using community pharmacies to identify undiagnosed cases of chronic obstructive pulmonary disease (COPD) at an early stage could save £264 million a year according to new research from the University of East Anglia. [More]
Regeneron, Sanofi report positive results from dupilumab Phase 2b study in patients with asthma

Regeneron, Sanofi report positive results from dupilumab Phase 2b study in patients with asthma

Regeneron Pharmaceuticals, Inc. and Sanofi today announced positive results from the interim analysis of a dose-ranging Phase 2b study of dupilumab in adult patients with uncontrolled moderate-to-severe asthma. Dupilumab is an investigational therapy blocking IL-4 and IL-13, two cytokines required for the Th2 immune response. [More]
Survey: Majority of U.S. adult women do not believe that they are up to date on vaccinations

Survey: Majority of U.S. adult women do not believe that they are up to date on vaccinations

A national survey from Rite Aid and National Foundation for Infectious Diseases reveals that the majority of adult women living in the United States do not believe they are up to date on vaccinations to protect against many preventable diseases. [More]
Perrigo agrees to acquire Omega for $4.5 billion

Perrigo agrees to acquire Omega for $4.5 billion

Perrigo Company plc, a leading global provider of "Quality Affordable Healthcare Products," and Omega Pharma NV, one of the largest OTC healthcare companies in Europe, headquartered in Nazareth, Belgium, today announced that they have entered into a definitive agreement in which Perrigo has agreed to acquire Omega for €3.6 billion, or $4.5 billion, comprised of the purchase of Omega's equity for €2.48 billion and the assumption of €1.1 billion in debt. [More]
Patients who receive lung cancer diagnosis during emergency visit report difficulties in seeing GP

Patients who receive lung cancer diagnosis during emergency visit report difficulties in seeing GP

MANY patients whose lung cancer is diagnosed as an emergency in hospital reported difficulties in previously seeing their GP, according to research presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool today (Tuesday). [More]
FDA approves Fluzone High-Dose vaccine sBLA to include efficacy data in Prescribing Information

FDA approves Fluzone High-Dose vaccine sBLA to include efficacy data in Prescribing Information

Sanofi Pasteur, the vaccines division of Sanofi, today announced that the U.S. Food and Drug Administration has approved the supplemental biologics license application (sBLA) for Fluzone High-Dose (Influenza Vaccine) to include efficacy data in the Prescribing Information. [More]
Spirometry fails to improve quality of life in asthmatic children

Spirometry fails to improve quality of life in asthmatic children

The results of two cluster randomised controlled trials in young asthma patients reveal that regular spirometry and medical review do not significantly affect asthma-related quality of life, report Australian researchers. [More]
Study shows that obese children may mistake asthma symptoms, overuse rescue medications

Study shows that obese children may mistake asthma symptoms, overuse rescue medications

New research shows obese children with asthma may mistake symptoms of breathlessness for loss of asthma control leading to high and unnecessary use of rescue medications. The study was published online in the Journal of Allergy and Clinical Immunology, the official scientific journal of the American Association of Allergy, Asthma and Immunology. [More]
Innovative treatment option for children with plastic bronchitis

Innovative treatment option for children with plastic bronchitis

A case study published recently in the journal Pediatrics describes an innovative, minimally invasive procedure that treated plastic bronchitis, a potentially life-threatening disease, in a six-year-old boy with a heart condition. Using new lymphatic imaging tools and catheterization techniques, physician-researchers eliminated bronchial casts, which are an accumulation of lymphatic material that clogged the child's airway. [More]
Myths, misconceptions about seasonal flu and flu vaccine

Myths, misconceptions about seasonal flu and flu vaccine

It's that time of year again. As days shorten, evenings become chilly and the trees start a showy display of color, it's time to roll up your sleeve and get your annual flu vaccine. [More]
New specialist outpatient vaccinations clinic for at-risk people to be opened at MedUni Vienna

New specialist outpatient vaccinations clinic for at-risk people to be opened at MedUni Vienna

At the Medical University of Vienna, Austria's first specialist vaccinations clinic for at-risk groups will open on 22nd October 2014 with an "Open Doors Day". This clinic specialises in patients who, as a result of illness or disease, require personalised care in relation to vaccinations. [More]
Columbia University professor recommends vaccination for people travelling abroad

Columbia University professor recommends vaccination for people travelling abroad

Planning to travel outside the U.S. this holiday season? Check with your primary care provider or travel clinic when you book your flight. [More]
Study shows diphenhydramine suppresses cough reflex sensitivity with Dr. Cocoa formulation

Study shows diphenhydramine suppresses cough reflex sensitivity with Dr. Cocoa formulation

Cough is among the most common complaints for which patients seek medical attention. Leading cough researcher Peter V. Dicpinigaitis, M.D., Professor of Clinical Medicine at New York's Albert Einstein College of Medicine, recently conducted a new cough challenge study among adults, whose results were first presented at the European Respiratory Society International Congress in September 2014. [More]