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Daratumumab achieves 29.2% overall response rate in heavily pre-treated patients with multiple myeloma

Daratumumab achieves 29.2% overall response rate in heavily pre-treated patients with multiple myeloma

Data from the international, multi-center, open-label, two-part, single-arm Phase 2 MMY2002 (SIRIUS) trial show treatment with single-agent daratumumab – an investigational, human anti-CD38 monoclonal antibody – achieved an overall response rate (ORR) of 29.2 percent (95% CI, 20.8-38.9), as assessed by an independent review committee, in heavily pre-treated patients with multiple myeloma. [More]
UB researchers successfully harness E. coli to generate new forms of antibiotics

UB researchers successfully harness E. coli to generate new forms of antibiotics

Like a dairy farmer tending to a herd of cows to produce milk, researchers are tending to colonies of the bacteria Escherichia coli (E. coli) to produce new forms of antibiotics -- including three that show promise in fighting drug-resistant bacteria. [More]
Pulmonary rehabilitation ‘should include sleep assessment’

Pulmonary rehabilitation ‘should include sleep assessment’

Researchers say that pulmonary rehabilitation programmes for patients with moderate to severe chronic obstructive pulmonary disease should include sleep assessment. [More]
DDW 2015: Experts explore efficacy of Stretta therapy for treating chronic GERD patients

DDW 2015: Experts explore efficacy of Stretta therapy for treating chronic GERD patients

A special presentation at Digestive Disease Week 2015 featured GERD experts weighing in on their successful experience using Stretta therapy to treat challenging patient populations suffering from GERD. [More]
Lilly Diabetes Alliance, Boehringer Ingelheim to present study results at ADA’s Scientific Sessions

Lilly Diabetes Alliance, Boehringer Ingelheim to present study results at ADA’s Scientific Sessions

The presentation of 35 abstracts will demonstrate the breadth and depth of the Boehringer Ingelheim and Eli Lilly and Company Diabetes alliance portfolio at the 75th American Diabetes Association's (ADA) Scientific Sessions® in Boston, June 5-9. [More]
Janssen, Bayer HealthCare initiate CALLISTO program to study rivaroxaban in patients with active cancer

Janssen, Bayer HealthCare initiate CALLISTO program to study rivaroxaban in patients with active cancer

Janssen Pharmaceuticals, Inc. and its development partner, Bayer HealthCare, today announced the initiation of CALLISTO, a new comprehensive clinical research program for their novel oral anticoagulant, rivaroxaban, in patients with active cancer. The studies are evaluating the medicine for the prevention and treatment of life-threatening blood clots in patients with a wide range of cancer types. [More]
Researchers make important breakthrough in identifying major drivers of excessive coughing

Researchers make important breakthrough in identifying major drivers of excessive coughing

Cough treatments could change dramatically after the herpes virus helped researchers discover that the respiratory tract links to two different parts of the nervous system. [More]
Two-drug combination improves lung function in some cystic fibrosis patients

Two-drug combination improves lung function in some cystic fibrosis patients

The combination of two drugs — an investigational drug used in conjunction with an already FDA-approved medication — improved lung function in patients with one form of cystic fibrosis, according to two new studies. [More]
Cough reflex sensitivity diminishes in participants exposed to e-cigarette, shows study

Cough reflex sensitivity diminishes in participants exposed to e-cigarette, shows study

With just one exposure to electronic-cigarette (e-cigarette) vapor, participants in a study of 30 healthy subjects demonstrated a diminishment of cough reflex sensitivity. [More]
No data exists to support long-term efficacy, safety of e-cigarettes as smoking cessation tool

No data exists to support long-term efficacy, safety of e-cigarettes as smoking cessation tool

There is little reliable evidence that electronic cigarettes are effective for long-term smoking cessation, according to a new analysis of the currently available research which was presented at the 2015 American Thoracic Society International Conference. [More]
IQWiG examines the added benefit of aclidinium bromide/formoterol drug combination in COPD patients

IQWiG examines the added benefit of aclidinium bromide/formoterol drug combination in COPD patients

The fixed-dose combination aclidinium bromide/formoterol has been approved since November 2014 for long-term treatment of adults with chronic obstructive pulmonary disease (COPD). [More]
Bronchitis can cause pneumonia, says Loyola physician

Bronchitis can cause pneumonia, says Loyola physician

When a cold has lasted too long or a cough is especially bothersome, it's important to see a medical professional. [More]
Long-term survivors of esophageal cancer still face continued risks, study finds

Long-term survivors of esophageal cancer still face continued risks, study finds

Patients with esophageal cancer who survive 5 years after undergoing surgery might breathe a sigh of relief and become complacent about continued monitoring. In fact, there is little published information on the outcome of patients with locally advanced esophageal cancer (LAEC) who survive beyond the 5-year mark. [More]
Researchers describe critical connection associated with environmental cause of silicosis, lung cancer

Researchers describe critical connection associated with environmental cause of silicosis, lung cancer

Researchers at the University of Louisville have detailed a critical connection associated with a major environmental cause of silicosis and a form of lung cancer. Their study is reported in today's Nature Communications. [More]
Lung cancer surgery patients at higher risk of developing venous thromboembolism

Lung cancer surgery patients at higher risk of developing venous thromboembolism

New evidence suggests that lung cancer surgery patients are at higher risk of developing venous thromboembolism, including deep vein thrombosis (DVT) and pulmonary embolism (PE), than previously thought, with elevated risks of complications or death. When thromboemboli occur, they may be asymptomatic or attributed to post-surgical pain or complications, and may reflect both the lung cancer itself as well as compromised lung function after surgery. [More]
Preclinical data from Synthetic Biologics' SYN-005 for Pertussis treatment presented at ECCMID 2015

Preclinical data from Synthetic Biologics' SYN-005 for Pertussis treatment presented at ECCMID 2015

Synthetic Biologics, Inc., a developer of pathogen-specific therapies for serious infections and diseases, with a focus on protecting the microbiome, announced that preclinical data from its novel SYN-005 program for the treatment of Pertussis were presented in two posters at ECCMID 2015 (European Congress of Clinical Microbiology and Infectious Diseases), on April 25, 2015, in Copenhagen, Denmark. [More]

Researchers examine parents' attitudes regarding sending their child to daycare when they are unwell

Researchers from the University of Bristol have, for the first time, investigated the process of decision-making that parents go through when faced with this situation. The research, published in The Journal of Public Health, reports that parents viewed coughs and colds as less serious and not as contagious as sickness and diarrhoea symptoms. [More]
National Immunization Awareness Week launched by the Honourable Rona Ambrose, Minister of Health

National Immunization Awareness Week launched by the Honourable Rona Ambrose, Minister of Health

Today, the Honourable Rona Ambrose, Minister of Health, and Dr. Gregory Taylor, Canada's Chief Public Health Officer, launched National Immunization Awareness Week, which runs from April 25 to May 2. They encouraged Canadians to stay healthy by making sure their vaccinations are up to date. [More]
Incidence of esophageal cancer linked to GERD rises six-fold in recent decades

Incidence of esophageal cancer linked to GERD rises six-fold in recent decades

Esophageal cancer is one of the fastest-growing and deadliest cancers in the U.S. According to the American Cancer Society, an estimated 17,000 new cases of esophageal cancer will be diagnosed in 2015. Incidence of adenocarcinoma, a type of esophageal cancer linked to GERD (gastroesophageal reflux disease) has risen six-fold in recent decades. [More]
Baxter submits BAX 855 NDA to Japan's MHLW for treatment of hemophilia A patients

Baxter submits BAX 855 NDA to Japan's MHLW for treatment of hemophilia A patients

Nektar Therapeutics reported today that partner Baxter International Inc. announced that the company has submitted a new drug application (NDA) to Japan's Ministry of Health, Labour and Welfare for the approval of BAX 855, an investigational, extended half-life recombinant factor VIII (rFVIII) treatment based on ADVATE [Antihemophilic Factor (Recombinant)] for patients over 12 years of age with hemophilia A. [More]
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