Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Human colon organoids fill gap in effectively modeling common GI diseases

Human colon organoids fill gap in effectively modeling common GI diseases

Study shows how high fat diets can alter gut bacteria to combat harmful inflammation

Study shows how high fat diets can alter gut bacteria to combat harmful inflammation

Microscopic fungus exacerbates Crohn's disease symptoms, mice study shows

Microscopic fungus exacerbates Crohn's disease symptoms, mice study shows

AMSBIO introduce range of cancer exosome samples

AMSBIO introduce range of cancer exosome samples

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Microbes can manipulate molecular machinery of host cells to influence health

Microbes can manipulate molecular machinery of host cells to influence health

Scientists identify gene linked to incurable bowel disorders

Scientists identify gene linked to incurable bowel disorders

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Researchers identify cells that drive autoimmune disease

Researchers identify cells that drive autoimmune disease

Researchers discover that microRNA can prevent excessive intestinal inflammation

Researchers discover that microRNA can prevent excessive intestinal inflammation

Stress management may be promising strategy to treat abdominal pain in IBD patients

Stress management may be promising strategy to treat abdominal pain in IBD patients

Study shows safety, efficacy of endoscopic needle knife therapy for intestinal strictures in IBD patients

Study shows safety, efficacy of endoscopic needle knife therapy for intestinal strictures in IBD patients

Researchers discover new mechanism that causes chronic intestinal inflammation

Researchers discover new mechanism that causes chronic intestinal inflammation

Dietary soy-protein may be effective adjunct therapy for inflammatory bowel diseases

Dietary soy-protein may be effective adjunct therapy for inflammatory bowel diseases

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

Synthetic biologists engineer gut bacteria capable of sensing colitis

Synthetic biologists engineer gut bacteria capable of sensing colitis

IBD patients with longer duration of disease have higher risk of developing NAFLD

IBD patients with longer duration of disease have higher risk of developing NAFLD