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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Pre-operative enteral nutrition linked to reduced rates of complications after Crohn's disease surgery

Pre-operative enteral nutrition linked to reduced rates of complications after Crohn's disease surgery

Despite improvements in medical care, about two-thirds of patients with Crohn's disease develop complications requiring intestinal surgery at some time, and post-operative healing can be complicated. [More]
Georgia Tech researchers find new way to improve treatment for inflammatory diseases

Georgia Tech researchers find new way to improve treatment for inflammatory diseases

Is a treatment only making things better or maybe also making some things a little worse? That can be a nagging question in some medical decisions, where side effects are possible. [More]
Researchers develop first sensor that can identify IBD and distinguish between two subtypes

Researchers develop first sensor that can identify IBD and distinguish between two subtypes

Researchers have developed the first sensor capable of objectively identifying inflammatory bowel disease (IBD) and distinguishing between its two subtypes. [More]
MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study. [More]
Powerful version of anti-inflammatory molecule may help protect vision in diabetic retinopathy

Powerful version of anti-inflammatory molecule may help protect vision in diabetic retinopathy

A more powerful version of an anti-inflammatory molecule already circulating in our blood may help protect our vision in the face of diabetes. [More]
New diet could treat pediatric patients with Crohn's disease, ulcerative colitis

New diet could treat pediatric patients with Crohn's disease, ulcerative colitis

In a first-of-its-kind study published today in the Journal of Clinical Gastroenterology, researchers from Seattle Children's and Children's Healthcare of Atlanta, led by Dr. David Suskind, a Seattle Children's gastroenterologist, found that diet alone can bring pediatric patients with active Crohn's disease and ulcerative colitis (UC) into clinical remission. [More]
New research offers valuable insight for developing more effective drugs to treat IBD

New research offers valuable insight for developing more effective drugs to treat IBD

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that includes Crohn's disease and ulcerative colitis. [More]
Genetic mutation may increase susceptibility to cytomegalovirus infection

Genetic mutation may increase susceptibility to cytomegalovirus infection

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection. [More]
New review provides insights on rates, predictors of relapse after surgery in Crohn's disease patients

New review provides insights on rates, predictors of relapse after surgery in Crohn's disease patients

Some patients with Crohn's disease, a chronic inflammatory disease that affects the lining of the digestive tract, require surgery to remove part or all of the large intestine; however, surgery does not cure the condition and many patients relapse after surgery. [More]
Cornell researchers develop chemical probe activated by UV light to control inflammation

Cornell researchers develop chemical probe activated by UV light to control inflammation

Black light does more than make posters glow. Cornell researchers have developed a chemical tool to control inflammation that is activated by ultraviolet (UV) light. [More]
Early life history and genetics may play crucial role in shaping gut microbiome

Early life history and genetics may play crucial role in shaping gut microbiome

Genetics and birthplace have a big effect on the make-up of the microbial community in the gut, according to research published Nov. 28. in the journal Nature Microbiology. [More]
DNA changes in blood samples could pave way for simple tests to diagnose IBD

DNA changes in blood samples could pave way for simple tests to diagnose IBD

Scientists have identified chemical changes in the DNA of patients with inflammatory bowel diseases that could improve screening for the conditions. [More]
New research shows immune paralysis in sepsis patients can be reversed

New research shows immune paralysis in sepsis patients can be reversed

Failure of the immune system during blood poisoning (sepsis) can be reversed by a specific sugar. [More]
Arthritis drug induces response and remission in patients with Crohn's disease, study finds

Arthritis drug induces response and remission in patients with Crohn's disease, study finds

Researchers at University of California San Diego School of Medicine have shown that ustekinumab, a human antibody used to treat arthritis, significantly induces response and remission in patients with moderate to severe Crohn's disease. [More]
FDA approves new assay for diagnosis of IBD

FDA approves new assay for diagnosis of IBD

Inova Diagnostics, a worldwide leader in autoimmune diagnostic reagents and systems for the clinical laboratory, is pleased to announce the US Food and Drug Administration clearance of QUANTA Lite Calprotectin Extended Range, an assay which aids in the diagnosis of Inflammatory Bowel Disease (IBD), and can help differentiate IBD from Irritable Bowel Syndrome (IBS). [More]
CannaCure Florida offers medical cannabis educational conference following legalization of marijuana

CannaCure Florida offers medical cannabis educational conference following legalization of marijuana

CannaCure Florida is proudly offering the most comprehensive medical cannabis educational conference following passage of Florida Amendment 2 legalizing medical marijuana. [More]
Regular consumption of dietary emulsifiers promotes colorectal cancer in mice

Regular consumption of dietary emulsifiers promotes colorectal cancer in mice

Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter intestinal bacteria in a manner that promotes intestinal inflammation and colorectal cancer, according to a new study. [More]
Researchers create new culture model of human intestine to study inflammatory bowel disease

Researchers create new culture model of human intestine to study inflammatory bowel disease

Inflammatory bowel disease (IBD) is a complex condition that requires a lifetime of care and increases a person's cancer risk. [More]
Many ulcerative colitis patients with anemia do not receive testing and treatment, study reports

Many ulcerative colitis patients with anemia do not receive testing and treatment, study reports

Many patients with ulcerative colitis don't receive recommended testing and treatment for the common problem of iron deficiency anemia, reports a study in the October issue of Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Wolters Kluwer. [More]
Esperite's business unit develops therapy for Crohn's disease perianal fistulas

Esperite's business unit develops therapy for Crohn's disease perianal fistulas

Esperite's business unit The Cell Factory in collaboration with Women's and Children's Health Department of the University of Padua and the Padua University Hospital are developing therapies for inflammatory bowel disease (IBD) using extracellular vesicles (EVs). [More]
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