Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Beneficial bacteria may be key to reverse gut inflammation seen in inflammatory bowel diseases

Beneficial bacteria may be key to reverse gut inflammation seen in inflammatory bowel diseases

New biomarkers may help in diagnosis and management of Crohn's disease

New biomarkers may help in diagnosis and management of Crohn's disease

Mice study shows role of yeast in aggravating IBD symptoms

Mice study shows role of yeast in aggravating IBD symptoms

Random variability may contribute to differences in gut microbe populations, study finds

Random variability may contribute to differences in gut microbe populations, study finds

New, low-cost biosimilar for IBD therapy shows efficacy and safety

New, low-cost biosimilar for IBD therapy shows efficacy and safety

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

Incidence of inflammatory bowel disease continues to increase in Denmark, research reveals

Incidence of inflammatory bowel disease continues to increase in Denmark, research reveals

Lower vitamin D levels increase risk of clinical relapse in Ulcerative Colitis patients, study finds

Lower vitamin D levels increase risk of clinical relapse in Ulcerative Colitis patients, study finds

DNA computer could be important step towards development of smart, 'intelligent' drugs

DNA computer could be important step towards development of smart, 'intelligent' drugs

HMS scientists listen to crosstalk between gut microbes and immune system

HMS scientists listen to crosstalk between gut microbes and immune system

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

FDA approves new drug to treat adults with moderate-to-severe plaque psoriasis

FDA approves new drug to treat adults with moderate-to-severe plaque psoriasis

IBD patients have less stable gut microbiome than healthy people, study shows

IBD patients have less stable gut microbiome than healthy people, study shows

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Researchers identify E. coli bacteria linking Crohn's disease to spondyloarthritis

Food: the good, the bad and the ugly

Food: the good, the bad and the ugly

UT Southwestern scientists discover gene that protects gut from IBD

UT Southwestern scientists discover gene that protects gut from IBD

Study finds new links between human genome and inflammation tracers

Study finds new links between human genome and inflammation tracers

Researchers map genetic changes resulting from short bowel syndrome

Researchers map genetic changes resulting from short bowel syndrome

Pre-operative enteral nutrition linked to reduced rates of complications after Crohn's disease surgery

Pre-operative enteral nutrition linked to reduced rates of complications after Crohn's disease surgery