Cystic Fibrosis News and Research

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Cystic fibrosis is a life threatening, inherited disease of the exocrine glands. The condition primarily affects the digestive and respiratory systems which become clogged with a thick, sticky mucus.

Cystic fibrosis is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene which results in an excess of salt and water passing into cells, causing a thick, sticky mucus to build up in bodily passageways.

In the airways, this mucus causes a persistent cough, wheezing, breathlessness, and repeated lung infections. In the digestive tract, the tubes that carry digestive enzymes from the pancreas into the small intestine become blocked, preventing the proper absorption of food nutrients. This can lead to poor weight gain, intestinal blockage (particularly in newborns), and foul-smelling, greasy stools.

There is no cure for cystic fibrosis, so treatment aims to ease symptoms and make the condition easier to live with. Bronchodilators may be used to help expand the airways, antibiotics to treat chest infections and physiotherapy can help expel mucus from the lungs.
The condition is most common in white people of northern European descent and is estimated to occurs in 1 in every 2,500 babies born in the UK, where babies are screened at birth for cystic fibrosis as part of the National Health Service newborn screening programme.
Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

Scientists map three-dimensional structure of protein that causes cystic fibrosis

Scientists map three-dimensional structure of protein that causes cystic fibrosis

Researchers uncover major clue to how mucus becomes abnormal in CF airways

Researchers uncover major clue to how mucus becomes abnormal in CF airways

Phage therapy could offer safe and effective treatment option for Cystic Fibrosis lung infections

Phage therapy could offer safe and effective treatment option for Cystic Fibrosis lung infections

McMaster researchers find new way to combat world's worst infectious diseases

McMaster researchers find new way to combat world's worst infectious diseases

Innovative ways to target antibiotic resistance in short term

Innovative ways to target antibiotic resistance in short term

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

New report expresses ethical concerns about use of non-invasive prenatal testing

New report expresses ethical concerns about use of non-invasive prenatal testing

Diagnosing infections through molecules in patient breath

Diagnosing infections through molecules in patient breath

New research pinpoints how bacteria get into lungs of healthy people

New research pinpoints how bacteria get into lungs of healthy people

New research pinpoints how immigrant microbes get to the lungs

New research pinpoints how immigrant microbes get to the lungs

New method that detects NMD efficiency could help in treatment of many diseases

New method that detects NMD efficiency could help in treatment of many diseases

Researchers developing compact respiratory assist device for children with lung failure

Researchers developing compact respiratory assist device for children with lung failure

UNC scientists isolate protein that could play role in asthmatics

UNC scientists isolate protein that could play role in asthmatics

Experts update cystic fibrosis guidelines for better diagnosis and personalized treatment

Experts update cystic fibrosis guidelines for better diagnosis and personalized treatment

First stem cell study could lead to development of therapy to reduce inflammation caused by CF

First stem cell study could lead to development of therapy to reduce inflammation caused by CF

Scientists identify potential therapeutic solutions to combat age-related fibrosis

Scientists identify potential therapeutic solutions to combat age-related fibrosis

GUMC researchers describe lab technique to fill gaps in clinical care and research

GUMC researchers describe lab technique to fill gaps in clinical care and research

Researchers explore ins and outs of genome sequencing in newborns

Researchers explore ins and outs of genome sequencing in newborns

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment