Cytokine News and Research

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Three cytokine pairs found to be responsible for the body's damaging response to sepsis

Sepsis -; when an infection causes the immune system to improperly target the body -; is one of the leading causes of death in the ICU.

8 Jan 2024

New approach leverages macrophages to treat traumatic brain injury

Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.

3 Jan 2024

Study: High-fat diets impact genes in the intestines, brain, and immune system

A UC Riverside study to motivate your new year's resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk.

3 Jan 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Very early in the COVID-19 pandemic clinical trials in patients hospitalized with COVID-19 confirmed that corticosteroids like dexamethasone reduced mortality, but they were harmful when applied at the first COVID-19 symptoms, due to the weakening of innate antiviral immunity, leading to delayed viral clearance and adverse outcomes in severe viral pneumonias.

28 Dec 2023

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Brain injury markers found in the blood months after COVID-19 infection

A new study published today (22 December 2023) in Nature Communications details that markers of brain injury are present in the blood many months after COVID-19 infection, despite inflammation blood tests being normal.

22 Dec 2023

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

Wars, drought, displacement, and instability are causing a dramatic increase in the number of pregnant and breastfeeding women around the world who suffer from malnutrition.

20 Dec 2023

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy.

19 Dec 2023

Study links omicron's cellular senescence to inflammation and long-COVID risk

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence."

15 Dec 2023

Study reveals unexpected role of immune cells in early human lung development

Immune cells play an active and intimate role in directing the growth of human lung tissue during development, researchers find, revolutionizing our understanding of early lung development and the role of immune cells outside of immunity.

15 Dec 2023

IFNγ identified as crucial for reducing pulmonary viral loads in COVID-19, new research shows

The role of type-2 interferon (IFNγ) in antiviral immunity.

14 Dec 2023

Daily consumption of prunes may reduce inflammation markers and bone loss effects

A new study published in The Journal of Nutrition shows daily consumption of prunes may reduce inflammation markers connected to bone signaling pathways and reduce the effects of bone loss among postmenopausal women.

12 Dec 2023

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Five DNA vaccine candidates based on different SARS-CoV-2 strains.

12 Dec 2023

New optimized vaccine approach targets Hepatitis C virus variability

A method to design vaccines for highly variable viruses like the hepatitis C virus.

12 Dec 2023

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm.

11 Dec 2023

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

A study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that CAR-T immunotherapy remains a viable option for patients who have lymphoma that goes into remission before the cell therapy begins.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Study published in Nature Immunology reveals that repeated mRNA COVID-19 vaccinations enhance immune response, especially in previously infected individuals, leading to a diversified and increased number of immune cell clones and a stronger ability to combat various virus strains.

7 Dec 2023

Cytokine News and Research

Three cytokine pairs found to be responsible for the body's damaging response to sepsis

New approach leverages macrophages to treat traumatic brain injury

Study: High-fat diets impact genes in the intestines, brain, and immune system

How immune cells shape our earliest breaths

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Common inflammation pathway turns anthrax toxin into killer

Brain injury markers found in the blood months after COVID-19 infection

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Study links omicron's cellular senescence to inflammation and long-COVID risk

Study reveals unexpected role of immune cells in early human lung development

IFNγ identified as crucial for reducing pulmonary viral loads in COVID-19, new research shows

Daily consumption of prunes may reduce inflammation markers and bone loss effects

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

New optimized vaccine approach targets Hepatitis C virus variability

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Study explores the intricate gut-brain-liver connection and its impact on health

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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