Cytokine News and Research

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Targeting SARS-CoV-2 with Chaga mushroom – a natural antiviral compound

A new study examines the potential binding interaction of the beneficial components of Chaga mushroom with that of the SARS-CoV-2 RBD.

24 Oct 2021

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

Researchers compare a large cohort of transcriptomic dataset maps of gene regulation by SARS-CoV-2 infection.

24 Oct 2021

New AI-based tool helps clinicians understand and better predict adverse effects of COVID-19

The symptoms and side effects of Covid-19 are scattered across a diagnostic spectrum. Some patients are asymptomatic or experience a mild immune response, while others report significant long-term illnesses, lasting complications, or suffer fatal outcomes.

22 Oct 2021

Influence of age on innate and adaptive immunity in COVID-19 patients

A new study investigates how age influences SARS-CoV-2 replication, innate and adaptive immune responses.

21 Oct 2021

Red blood cells play a much larger role in the immune system than previously thought

New research has revealed that red blood cells function as critical immune sensors by binding cell-free DNA, called nucleic acid, present in the body's circulation during sepsis and COVID-19, and that this DNA-binding capability triggers their removal from circulation, driving inflammation and anemia during severe illness and playing a much larger role in the immune system than previously thought.

20 Oct 2021

Biomarker predicts severity of SARS-CoV-2 infection in patients

A new study investigates a biomarker to predict the severity of disease in patients infected with SARS-CoV-2.

20 Oct 2021

The neutralization potential of nanobodies against SARS-CoV-2

A recent review describes the role of nanobodies as a new class of recombinant antibodies that are used in the treatment of COVID-19.

20 Oct 2021

Novel approach to predict outcomes in COVID-19 patients

In a recent study, researchers have used the predictive power of chest CT scans and plasma cytokines to predict death and severity in COVID-19 patients.

19 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Now, a new medRxiv* preprint study finds mothers vaccinated either one of the messenger RNA (mRNA) vaccines transferred neutralizing antibodies and cytokines, including interferon-gamma (IFNγ), to a breastfeeding child. Additionally, the humoral response in breastmilk was effective in neutralizing four variants of concern.

18 Oct 2021

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

To address the gaps in the knowledge, a team of researchers from the University of California and the Gladstone Institute of Virology conducted 39-parameter phenotyping by cytometry by time of flight (CyTOF) on 33 longitudinal specimens from 11 mRNA-vaccinated individuals, of which six had previously been infected and recovered from COVID-19.

18 Oct 2021

Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

The efficacy and safety of a DNA-based vaccine are investigated, finding that the unique vaccine imparts a robust and long-lasting immunogenic response.

15 Oct 2021

Study reveals a detrimental role of the immune system in Lewy body dementias

T-cells respond to buildups of alpha-synuclein, the aggregated protein clumps that are a feature of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease (PD), according to a Northwestern Medicine study published in Science.

14 Oct 2021

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

A new study reports a cell-based assay that involved the isolation and quantification of SARS-CoV-2 Mpro in human cells in the absence of other proteins.

14 Oct 2021

Anti-rheumatic drug as a potential candidate for treating COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces inflammatory cytokine storms. But an FDA-approved anti-rheumatic drug, Auranofin, used to treat autoimmune and infectious diseases, may also help serve as an antiviral treatment for COVID-19 infection.

13 Oct 2021

New study finds SARS-CoV-2 causes retinal infection

Can coronavirus disease 2019 (COVID-19) affect the eye? New research suggests the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the eye and infect photoreceptor and retinal ganglion cells. In addition, SARS-CoV-2 infection increases the expression of several inflammatory genes, including the cytokine interleukin 33 (IL33), which is linked to COVID-19 disease and retinal degeneration.

13 Oct 2021

Rapid measurement of SARS-CoV-2 spike T-cells

Researchers measure SARS-CoV-2 T-cell responses in individuals vaccinated or in those who developed immunity from a prior natural infection.

12 Oct 2021

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new paper shows that human TLR3, TLR7, and TLR8 receptors are activated with naturally occurring RNA, but this is eliminated once modified nucleosides such as m5C, m6A, m5U s2U, or pseudouridine are incorporated.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

An investigation of SARS-CoV-2 infection in diabetic pregnancies

Researchers discuss the basic and clinical science of the potential inter-relationships between diabetes mellitus and COVID-19 in pregnancies.

11 Oct 2021

Cytokine News and Research

Targeting SARS-CoV-2 with Chaga mushroom – a natural antiviral compound

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

New AI-based tool helps clinicians understand and better predict adverse effects of COVID-19

Influence of age on innate and adaptive immunity in COVID-19 patients

Red blood cells play a much larger role in the immune system than previously thought

Biomarker predicts severity of SARS-CoV-2 infection in patients

The neutralization potential of nanobodies against SARS-CoV-2

Novel approach to predict outcomes in COVID-19 patients

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

SARS-CoV-2 antibodies detected in breast milk of vaccinated mothers

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

Study reveals a detrimental role of the immune system in Lewy body dementias

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

Anti-rheumatic drug as a potential candidate for treating COVID-19

New study finds SARS-CoV-2 causes retinal infection

Rapid measurement of SARS-CoV-2 spike T-cells

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

An investigation of SARS-CoV-2 infection in diabetic pregnancies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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