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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.
New research provides insight into how estrogen modulates fear learning

New research provides insight into how estrogen modulates fear learning

Low estrogen levels may make women more susceptible to the development of post-traumatic stress disorder (PTSD) at some points in their menstrual cycles or lifetimes, while high estrogen levels may be protective. [More]
Study finds link between obesity-related disease and epigenetic modifications

Study finds link between obesity-related disease and epigenetic modifications

Obesity has been linked to "letter" changes at many different sites in the genome, yet these differences do not fully explain the variation in people's body mass index (BMI) or why some overweight people develop health complications while others don't. [More]
Researchers identify new subgroup of cervical cancers with different genetic features

Researchers identify new subgroup of cervical cancers with different genetic features

A team of University of South Carolina scientists led by Carolyn Banister and Phillip Buckhaults has identified a new subtype of cervical cancer that, like most cervical cancers, is triggered by human papillomavirus (HPV) but whose growth is not directed by the virus, suggesting that therapy targeting these tumors' distinct genomic pathways may improve patient outcomes over standard treatment. [More]
Epigenetic changes favor development of fatty liver in humans and mice

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. [More]
Research sheds new light on key drivers of cancer metastasis

Research sheds new light on key drivers of cancer metastasis

Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumours to other parts of the body. This phenomenon - known as metastasis - causes about 90 per cent of all cancer deaths. [More]
Viral infection during pregnancy affects maternal care and can trigger depression in offspring

Viral infection during pregnancy affects maternal care and can trigger depression in offspring

A viral infection in a pregnant woman not only affects her subsequent ability to provide maternal care but can also trigger depression in her offspring, which can then even extend into the next generation as a result of changes to genetic mechanisms in the brain. [More]
Honeybee brain helps unravel mystery behind long-term memory formation

Honeybee brain helps unravel mystery behind long-term memory formation

A breakdown of memory processes in humans can lead to conditions such as Alzheimer's and dementia. [More]
PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

Prostate-specific antigen (PSA) and other biomarkers are essential tools for diagnosing and monitoring prostate cancer. [More]
Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers of the Sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, have first described the methylation profile of Ewing's sarcoma, a cancer of bone and soft tissues that mainly affects children and teenagers. [More]
Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

A multi-institutional group of researchers, led by investigators at Children's Hospital Los Angeles and the University of Michigan, have identified a simple and inexpensive tool for assessing the prognosis of pediatric brain tumors called ependymomas. [More]
Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions in future generations, potentially putting offspring at risk for such conditions as depression, anxiety, and metabolic disorders, a Loyola University Chicago Stritch School of Medicine study has found. [More]
Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

B12 deficiency during pregnancy may predispose children to metabolic problems such as type-2 diabetes, according to research presented today at the Society for Endocrinology's annual Conference in Brighton. [More]
UCLA research shows epigenetic clock predicts lifespan

UCLA research shows epigenetic clock predicts lifespan

Why do some people lead a perfectly healthy lifestyle yet still die young? A new international study suggests that the answer lies in our DNA. [More]
DNA damage caused by smoking may last a lifetime

DNA damage caused by smoking may last a lifetime

Results of a study published this week show that the effects of smoking on DNA are wide-reaching and some persist long after a person has stopped smoking. The information gained may help improve our understanding of smoking-related diseases. [More]
UAB researchers find microRNA as potential therapeutic target for MDD

UAB researchers find microRNA as potential therapeutic target for MDD

A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide. [More]
Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

The children of traumatized people have long been known to be at increased risk for posttraumatic stress disorder (PTSD), and mood and anxiety disorders. [More]
DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons. [More]
Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

New research led by scientists from King's College London and the University of Bristol has found that a high-fat, high-sugar diet during pregnancy may be linked to symptoms of ADHD in children who show conduct problems early in life. [More]
NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze. [More]
UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

Though the drug levodopa can dramatically improve Parkinson's disease symptoms, within five years one-half of the patients using L-DOPA develop an irreversible condition -- involuntary repetitive, rapid and jerky movements. [More]
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