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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.
Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers of the Sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, have first described the methylation profile of Ewing's sarcoma, a cancer of bone and soft tissues that mainly affects children and teenagers. [More]
Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

A multi-institutional group of researchers, led by investigators at Children's Hospital Los Angeles and the University of Michigan, have identified a simple and inexpensive tool for assessing the prognosis of pediatric brain tumors called ependymomas. [More]
Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions in future generations, potentially putting offspring at risk for such conditions as depression, anxiety, and metabolic disorders, a Loyola University Chicago Stritch School of Medicine study has found. [More]
Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

B12 deficiency during pregnancy may predispose children to metabolic problems such as type-2 diabetes, according to research presented today at the Society for Endocrinology's annual Conference in Brighton. [More]
UCLA research shows epigenetic clock predicts lifespan

UCLA research shows epigenetic clock predicts lifespan

Why do some people lead a perfectly healthy lifestyle yet still die young? A new international study suggests that the answer lies in our DNA. [More]
DNA damage caused by smoking may last a lifetime

DNA damage caused by smoking may last a lifetime

Results of a study published this week show that the effects of smoking on DNA are wide-reaching and some persist long after a person has stopped smoking. The information gained may help improve our understanding of smoking-related diseases. [More]
UAB researchers find microRNA as potential therapeutic target for MDD

UAB researchers find microRNA as potential therapeutic target for MDD

A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide. [More]
Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

The children of traumatized people have long been known to be at increased risk for posttraumatic stress disorder (PTSD), and mood and anxiety disorders. [More]
DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons. [More]
Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

New research led by scientists from King's College London and the University of Bristol has found that a high-fat, high-sugar diet during pregnancy may be linked to symptoms of ADHD in children who show conduct problems early in life. [More]
NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome

Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze. [More]
UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

Though the drug levodopa can dramatically improve Parkinson's disease symptoms, within five years one-half of the patients using L-DOPA develop an irreversible condition -- involuntary repetitive, rapid and jerky movements. [More]
Study identifies two proteins crucial for self-renewal of skin stem cells

Study identifies two proteins crucial for self-renewal of skin stem cells

Our skin renews, heals wounds, and regenerates the hair that covers it thanks to a small group of stem cells. These cells continually produce new ones, which appear on the skin surface after a few days. [More]
Scientists identify epigenetic alterations involved in autoinflammatory diseases

Scientists identify epigenetic alterations involved in autoinflammatory diseases

Researchers from the Chromatin and Disease group of the Bellvitge Biomedical Research Institute, led by Dr. Esteban Ballestar, have identified for the first time epigenetic alterations in autoinflammatory diseases, particularly in cryopyrin-associated periodic syndromes (CAPS). [More]
Extra-coding RNA modulates neuronal DNA methylation patterns

Extra-coding RNA modulates neuronal DNA methylation patterns

The creation of memories in the brain involves addition or removal of methyl groups at precise spots on chromosomal DNA. But what controls the careful targeting of these neuronal DNA methylation dynamics? [More]
Study demonstrates epigenetic link between environment and pubertal onset in humans

Study demonstrates epigenetic link between environment and pubertal onset in humans

Danish researchers have discovered a possible epigenetic link between the environment and pubertal timing. [More]
Advances in epigenome sequencing technologies can allow comprehensive analysis of cancers

Advances in epigenome sequencing technologies can allow comprehensive analysis of cancers

An international research collaboration led by UCL scientists has developed ways to improve the quality and accuracy of information harvested from epigenome sequencing datasets in two new research papers published jointly in Nature Biotechnology and Nature Communications today. According to the studies, epigenome sequencing technologies can allow for more comprehensive analysis of cancers - a key component in the development of targeted approaches to combat cancer. [More]
Positive environment can reverse trauma-related behavioral alterations in mice

Positive environment can reverse trauma-related behavioral alterations in mice

Traumatic experiences in childhood increase the risk of developing behavioral and psychiatric disorders later in life. It is also known that the consequences of a trauma can likewise be observed in the children of people affected even if those children have themselves not experienced any trauma. [More]
TUM scientists identify four new risk genes altered in MS patients

TUM scientists identify four new risk genes altered in MS patients

Scientists of the Technical University of Munich and the Max Planck Institute of Psychiatry have identified four new risk genes that are altered in German patients with multiple sclerosis (MS). [More]
QIAGEN announces launch of QIAsure Methylation Test to detect cervical cancer risk

QIAGEN announces launch of QIAsure Methylation Test to detect cervical cancer risk

QIAGEN N.V. today announced the launch of the QIAsure Methylation Test, a novel CE-marked molecular diagnostic test for use in differentiating patients' risk of developing cervical cancer. [More]
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