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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.
B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

​An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. [More]
Study shows R9-caPep compound blocks PCNA actions in neuroblastoma cells

Study shows R9-caPep compound blocks PCNA actions in neuroblastoma cells

Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. [More]
Protein expression predicts postop NSCLC recurrence, survival

Protein expression predicts postop NSCLC recurrence, survival

US-based researchers have identified a panel of 12 proteins that may help predict overall survival and the risk of recurrence in patients treated with surgery for non-small-cell lung cancer. [More]
Scientists uncover surprising link between brain development and gene tied to breast cancer

Scientists uncover surprising link between brain development and gene tied to breast cancer

Scientists at the Salk Institute have uncovered details into a surprising-and crucial-link between brain development and a gene whose mutation is tied to breast and ovarian cancer. [More]
Stowers team reports genome-wide analysis of genes that drive cell division in multicellular organism

Stowers team reports genome-wide analysis of genes that drive cell division in multicellular organism

​In textbooks, the grand-finale of cell division is the tug-of-war fought inside dividing cells as duplicated pairs of chromosomes get dragged in opposite directions into daughter cells. [More]

Researchers discover protein for treatment of anaplastic thyroid carcinoma

Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers from the National University of Singapore (NUS) have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2 (LAMC2), has the potential to be an ideal target for the treatment of ATC. [More]

NUS researchers discover promising treatment for anaplastic thyroid carcinoma

Anaplastic thyroid carcinoma is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers from the National University of Singapore have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2 (LAMC2), has the potential to be an ideal target for the treatment of ATC. [More]
Researchers detail how psoralen blocks signaling pathway of HER2-positive cancers

Researchers detail how psoralen blocks signaling pathway of HER2-positive cancers

A common compound known to fight lymphoma and skin conditions actually has a second method of action that makes it particularly deadly against certain aggressive breast tumors, researchers at Duke Medicine report. [More]
Pfizer’s palbociclib Phase 2 trial achieves primary endpoint in patients with advanced breast cancer

Pfizer’s palbociclib Phase 2 trial achieves primary endpoint in patients with advanced breast cancer

Pfizer Inc. today announced that the randomized Phase 2 trial [PALOMA-1] of palbociclib achieved its primary endpoint by demonstrating a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for the combination of palbociclib and letrozole compared with letrozole alone in post-menopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) locally advanced or newly diagnosed metastatic breast cancer. [More]
International study develops refined method to identify individuals at risk for certain inherited cancer

International study develops refined method to identify individuals at risk for certain inherited cancer

An international study has developed a refined method to identify people at risk for certain inherited cancer as a result of Lynch syndrome. [More]
Activation of protein P300 plays central role in DNA repair in hippocampal neurons

Activation of protein P300 plays central role in DNA repair in hippocampal neurons

Various medications have been developed to treat neurodegenerative disorders, and drugs without significant side effects are gaining widespread interest such disorders. [More]

Scientists unveil novel piece of puzzle of cancer cell DNA repair mechanisms

Research with a Finnish background facilitates the development of more effective cancer medication. Cancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. [More]
Researchers discover new human enzyme that facilitates DNA repair during DNA copying process

Researchers discover new human enzyme that facilitates DNA repair during DNA copying process

Every day, the human body produces new cells to regenerate tissues and repair those that have suffered injury. Each time this happens, the cells make copies of their DNA that they will pass on to the resulting daughter cells. This process of copying the DNA, also called replication, is very delicate, given that it can generate severe alterations in the DNA that are associated with malignant transformation or ageing. [More]
A*STAR scientists discover potential target to weed out progression of cancer

A*STAR scientists discover potential target to weed out progression of cancer

Scientists at A*STAR have discovered an enzyme, Wip1 phosphatase, as a potential target to weed out the progression of cancer. Although studies in the past have revealed that this enzyme plays a critical role in regulating the budding of tumours, scientists have for the first time unearthed a mechanism for its mode of action. [More]

Research findings could offer new insights into how defective cells can multiply in diseases

A rudimentary form of life that is found in some of the harshest environments on earth is able to sidestep normal replication processes and reproduce by the back door, researchers at The University of Nottingham have found. [More]
Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

Diverse Neurological Disorders Appear To Share Tangled Metabolic Roots

... [More]
Gene mutation offers clues to development of diverse neurological disorders

Gene mutation offers clues to development of diverse neurological disorders

A research team, headed by Theodore Friedmann, MD, professor of pediatrics at the University of California, San Diego School of Medicine, says a gene mutation that causes a rare but devastating neurological disorder known as Lesch-Nyhan syndrome appears to offer clues to the developmental and neuronal defects found in other, diverse neurological disorders like Alzheimer's, Parkinson's and Huntington's diseases. [More]
New research explains how DNA strands repair themselves

New research explains how DNA strands repair themselves

​Researchers have discovered the details of how cells repair breaks in both strands of their DNA, a potentially devastating kind of DNA damage. [More]
Study: Changes in expression of various isoforms might play role in cancer development

Study: Changes in expression of various isoforms might play role in cancer development

Spool-like proteins called histones play a crucial role in packaging the nearly seven feet of DNA found in most human cells. A new study shows that a group of histones that are thought to behave the same way actually are functionally distinct proteins. [More]

Researchers discover role played by epigenetic factors in senescence and age-related diseases

One way cells promote tumor suppression is through a process called senescence, an irreversible arrest of proliferation. Senescence is thought to be associated with normal aging, but is also a protective measure by the body against run-away cell replication. [More]