DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Scientists map all yeast proteins across cell cycle for the first time

An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.

23 Apr 2024

Discovery of DNA repair mechanism advances understanding of how human cells stay healthy

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.

17 Apr 2024

Unlocking the role of lncREST RNA in DNA replication and repair

Researchers at Cima Universidad de Navarra have discovered that a ribonucleic acid that does not contain information to make proteins (long non-coding RNA) plays a crucial role in signalling and repairing errors in DNA replication during cell division.

4 Mar 2024

RAD51 protein identified as a key player in preventing DNA re-replication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent.

4 Mar 2024

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

Genetic variant research in hypertension has identified numerous associations but is unlikely to yield new treatments, emphasizing the gap between scientific discovery and clinical application.

27 Feb 2024

AI tool helps develop the most complete map of the bacterial essential interactome

Universitat Autonoma de Barcelona (UAB) researchers have produced the most complete map of the bacterial essential interactome, i.e. how proteins combine and interact to perform functions essential for their survival.

23 Feb 2024

Identification of genetic determinants of micronucleus formation

The genetic determinants of micronuclei formation (MN).

19 Feb 2024

Study uncovers more than one hundred key genes linked to DNA damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

14 Feb 2024

Magnesium's pivotal role in slowing aging's impact

Review highlights magnesium's critical role in mitigating aging hallmarks, including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion, suggesting that maintaining adequate magnesium levels could support healthy aging.

13 Feb 2024

Study reveals a crucial survival tactic employed by cancer cells

A study led by the group of Didier Trono at EPFL has revealed a crucial survival tactic employed by cancer cells.

12 Feb 2024

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

8 Feb 2024

XRCC1 shows potential as a prognostic and immunological pan-cancer biomarker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, "XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis."

30 Jan 2024

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

30 Jan 2024

Machine learning algorithm decodes mutations driving cancer treatment resistance

In a groundbreaking study published on January 18, 2024, in Cancer Discovery, scientists at University of California San Diego School of Medicine leveraged a machine learning algorithm to tackle one of the biggest challenges facing cancer researchers: predicting when cancer will resist chemotherapy.

18 Jan 2024

Unearthing individual-level mutation risk patterns

Mutations, which occur continuously in every cell of our bodies, are a key contributor to cancer, ageing, and neurodegeneration.

10 Jan 2024

Early embryo DNA replication program reveals unexpected flexibility

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next.

20 Dec 2023

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Latest super-resolution microscopy methods now achieve an optical resolution in the range of a few nanometers.

1 Dec 2023

Genome haplarithmisis sheds light on complex genetic landscape of miscarriages

A new study published in Nature Medicine reports on a chromosomal analysis of over 1,700 spontaneous early miscarriages.

27 Nov 2023

Study sheds light on origins of breast cancer in people with BRCA2 mutations

A pioneering study led by Professor Ashok Venkitaraman from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and Dr Mona Shehata from the University of Cambridge (UK) has uncovered vital insights into the distinct effects of BRCA2 mutations on breast tissue cells, shedding light on early breast cancer development in people with BRCA2 mutations.

1 Nov 2023

Study suggests a potential strategy to combat aggressive brain tumors

A new study has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

12 Oct 2023