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Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus. Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the Aedes mosquito. However, Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans, is the most common Aedes species. Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. Important risk factors for DHF include the strain of the infecting virus, as well as the age, and especially the prior dengue infection history of the patient.
OVC research may help improve cancer treatment

OVC research may help improve cancer treatment

Cancer treatment in people could be transformed thanks to a study on treating cancer in animals led by researchers from the Ontario Veterinary College at the University of Guelph. [More]
Scientists use machine learning to interpret mosquito genome

Scientists use machine learning to interpret mosquito genome

Scientists are using machine learning to identify important sequences of DNA within the mosquito genome that regulate how the insect's cells develop and behave. [More]
Telephone-based disease surveillance system can forecast dengue fever outbreaks

Telephone-based disease surveillance system can forecast dengue fever outbreaks

A team of scientists has developed a system that can forecast the outbreak of dengue fever by simply analyzing the calling behavior of citizens to a public-health hotline. [More]
Pre-existing dengue antibodies can intensify Zika virus infection

Pre-existing dengue antibodies can intensify Zika virus infection

Previous exposure to the dengue virus may increase the potency of Zika infection, according to research from Imperial College London. [More]
Tackling Zika: are insect repellents the answer? An interview with Bruno Jactel

Tackling Zika: are insect repellents the answer? An interview with Bruno Jactel

The repellents that are used today are mostly based on what we call chemical pesticides. These products are used to repel mosquitoes as well as ticks. They are very broadly used, but there are different issues surrounding their use. [More]
Warming temperatures may increase risk for dengue outbreaks in Europe

Warming temperatures may increase risk for dengue outbreaks in Europe

Increasing temperatures will enlarge Europe's seasonal window for the potential spread of mosquito-borne viral disease, expanding the geographic areas at risk for a dengue epidemic to include much of Europe. The findings by researchers at Umea University in Sweden are published in the journal EBioMedicine. [More]
Research describes first new mouse model for Zika infection in decades

Research describes first new mouse model for Zika infection in decades

Efforts to combat the rapid spread of Zika virus got a boost this week as researchers at the University of Texas Medical Branch, Galveston (UTMB) announced the first peer-reviewed publication of a mouse model for Zika infection reported in decades. [More]
Biological change in mosquito mating could be used to fight mosquito-borne diseases

Biological change in mosquito mating could be used to fight mosquito-borne diseases

Genetic cues from male Aedes aegypti mosquitoes passed on during sex affect which genes are turned on or off in a females' reproductive tract post-mating, including genes related to blood feeding, egg development and immune defense, according to new Cornell research. [More]
Novel way proposed for developing infectious disease models to uncover hidden patterns of transmission

Novel way proposed for developing infectious disease models to uncover hidden patterns of transmission

Ebola. Chikungunya. Zika. Once rare and exotic pathogens keep popping up and turning into household names. It's the new reality as the climate warms, humans expand more into wildlife habitats and air travel shrinks the distances across the globe. [More]
WRAIR researchers publish results from Plasmodium vivax malaria vaccine study

WRAIR researchers publish results from Plasmodium vivax malaria vaccine study

Walter Reed Army Institute of Research researchers recently published the results of testing a Plasmodium vivax malaria vaccine candidate in a human challenge model. [More]
Zika virus can cross the placental barrier, according to new study

Zika virus can cross the placental barrier, according to new study

A study of pregnant women in Brazil has confirmed the presence of Zika virus in the amniotic fluid of two women who had displayed Zika-like symptoms during their pregnancies. [More]
ESCMID gathers more solid data to better assess Zika virus risks, prepares for possible outbreak in Africa, Europe

ESCMID gathers more solid data to better assess Zika virus risks, prepares for possible outbreak in Africa, Europe

Experts at the European Society of Clinical Microbiology and Infectious Diseases – an organization promoting research, risk assessment, knowledge sharing and best practices in the fight against infectious diseases – are developing tools to monitor the spread of the Zika virus and are conducting research to gather more solid data to better assess the risks associated with the infection. [More]

El Niño plays significant role in outbreak of haemorrhagic fevers

The dengue virus affects 390 million people globally every year, and fears are that early 2016 will see an epidemic, particularly in South-East Asia, due to the predicted extreme intensity of El Niño. A new study published in the Proceedings of the National Academy of Sciences has revealed the significant role that this monster climatic phenomenon plays in the outbreak of haemorrhagic fevers. [More]
Zika virus threat across the Americas

Zika virus threat across the Americas

Yesterday, the World Health Organization (WHO) announced that the Zika virus outbreak in Brazil was “spreading explosively” in the Americas and that as many as four million people could be infected by the end of the year. [More]
Zika virus expected to spread across the U.S., says WHO

Zika virus expected to spread across the U.S., says WHO

On Monday (Jan. 25, 2016), the World Health Organization announced that Zika virus, a mosquito-borne illness that in the past year has swept quickly throughout equatorial countries, is expected to spread across the Americas and into the United States. [More]
A Thai man with Zika virus has been hospitalized in Taiwan

A Thai man with Zika virus has been hospitalized in Taiwan

A man from Thailand has been hospitalized in Taiwan after having arrived there infected with Zika virus, an agent thought to be associated with brain-damaging birth defects in infants. [More]
Large-scale clinical trial to evaluate dengue vaccine launched in Brazil

Large-scale clinical trial to evaluate dengue vaccine launched in Brazil

A large-scale clinical trial to evaluate whether a candidate vaccine can prevent the mosquito-borne illness dengue fever has been launched in Brazil. The vaccine, TV003, was developed by scientists in the laboratory of Stephen Whitehead, Ph.D., at NIH's National Institute of Allergy and Infectious Diseases (NIAID). [More]

Simplified mathematical model to study spread of dengue fever in urban areas

Mathematics is often implemented in healthcare and medical research. From health management to the bio-pharmaceutical fields, math modeling can be used to predict the spread of diseases, how to prevent epidemics and so much more. [More]
Findings show promising evidence for creating broad-spectrum antiviral

Findings show promising evidence for creating broad-spectrum antiviral

UW researchers working in collaboration with Kineta Inc. and the University of Texas at Galveston have shown that making a drug-like molecule to turn on innate immunity can induce genes to control infection in several -known viruses. [More]
SLU researcher discovered world's first dengue vaccine

SLU researcher discovered world's first dengue vaccine

A vaccine to prevent dengue fever discovered by a Saint Louis University researcher in 1997 and now licensed worldwide by Sanofi Pasteur has been approved for use in Mexico. Dengvaxia is the world's first vaccine approved to prevent dengue fever, which is a virus spread by mosquitoes primarily in tropical and sub-tropical areas. [More]
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