Dopamine News and Research RSS Feed - Dopamine News and Research

Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.
Urge incontinence therapy may relieve stress incontinence

Urge incontinence therapy may relieve stress incontinence

Anticholinergic medication appears to be effective as a treatment for stress and mixed urinary incontinence, results of a small clinical trial indicate. [More]
Study demonstrates that Parkinson's patients are more creative than their healthy peers

Study demonstrates that Parkinson's patients are more creative than their healthy peers

Prof. Rivka Inzelberg of Tel Aviv University's Sackler Faculty of Medicine and the Sagol Neuroscience Center at Sheba Medical Center, Tel Hashomer, documented the exceptional creativity of Parkinson's patients two years ago in a review for Behavioral Neuroscience. Since then, she has conducted the first empirical study to verify a link between Parkinson's disease and artistic inclination. [More]
Sleep problems in PD patients can worsen in later stages of disease

Sleep problems in PD patients can worsen in later stages of disease

Up to 70% of Parkinson's disease (PD) patients experience sleep problems that negatively impact their quality of life. [More]
Parkinson's disease drug could also help people with phobias or PTSD

Parkinson's disease drug could also help people with phobias or PTSD

A drug used to treat Parkinson's disease could also help people with phobias or post-traumatic stress disorder (PTSD). Scientists of the Translational Neurosciences Research Center at Johannes Gutenberg University Mainz are currently exploring the effects of psychotherapy to extinguish fears in combination with L-dopa. [More]
Neuroprotective effects of lithium are likely related to gene expressions

Neuroprotective effects of lithium are likely related to gene expressions

Lithium, as a neuroprotective agent, benefits for neuronal survival. Recent cDNA array studies have demonstrated that mood stabilizer lithium exhibits neuroprotective effects through multiple targets. [More]
Cinnamon can be used to halt disease progression in Parkinson's patients

Cinnamon can be used to halt disease progression in Parkinson's patients

Neurological scientists at Rush University Medical Center have found that using cinnamon, a common food spice and flavoring material, can reverse the biomechanical, cellular and anatomical changes that occur in the brains of mice with Parkinson's disease (PD). [More]
Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD. [More]
Study details brain mechanisms involved with addictive substances

Study details brain mechanisms involved with addictive substances

The National Institutes of Health has turned to neuroscientists at the nation's most "Stone Cold Sober" university for help finding ways to treat drug and alcohol addiction. [More]
Scientists one step closer to understanding the causes of Parkinson's disease

Scientists one step closer to understanding the causes of Parkinson's disease

Scientists have taken a step closer to understanding the causes of Parkinson's disease, identifying what's happening at a cellular level to potentially help develop future treatments. [More]
DBS improves motor and non motor symptoms of patients with early Parkinson's disease

DBS improves motor and non motor symptoms of patients with early Parkinson's disease

Deep brain stimulation (DBS) has become a well-recognized non-pharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson's disease. [More]
Scientists use femtosecond lasers to tackle Parkinson's disease

Scientists use femtosecond lasers to tackle Parkinson's disease

Scientists are combining physics and neurobiology to tackle Parkinson's disease. The Okinawa Institute of Science and Technology Graduate University's Femtosecond Spectroscopy Unit and Neurobiology Research Unit, along with collaborators at the University of Otago, New Zealand are using lasers, nanotechnology and neuroscience to develop a new, versatile drug delivery system. [More]
Brain iron levels offer potential biomarker in the diagnosis of ADHD

Brain iron levels offer potential biomarker in the diagnosis of ADHD

Brain iron levels offer a potential biomarker in the diagnosis of attention deficit hyperactivity disorder (ADHD) and may help physicians and parents make better informed treatment decisions, according to new research published online in the journal Radiology. [More]

Failing dopamine pump damages brain cells of patients with Parkinson's disease

A study group at the Medical University of Vienna's Centre for Brain Research has investigated the function of an intracellular dopamine pump in Parkinson's patients compared to a healthy test group. [More]
Increase in protein helps store dopamine and protects from Parkinson's disease

Increase in protein helps store dopamine and protects from Parkinson's disease

Researchers from Emory's Rollins School of Public Health discovered that an increase in the protein that helps store dopamine, a critical brain chemical, led to enhanced dopamine neurotransmission and protection from a Parkinson's disease-related neurotoxin in mice. [More]
Combination of effective drugs for Parkinson's disease controls symptoms of Rett syndrome in mice

Combination of effective drugs for Parkinson's disease controls symptoms of Rett syndrome in mice

IDIBELL researchers, led by the director of the Program for Epigenetics and Cancer Biology, ICREA researcher and Professor of Genetics at the University of Barcelona, Manel Esteller, have shown that a combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease. [More]
PD MED trial: Levodopa drug better for long-term treatment of newly diagnosed PD

PD MED trial: Levodopa drug better for long-term treatment of newly diagnosed PD

For long-term treatment of newly diagnosed Parkinson’s disease (PD), the old drug levodopa provides better mobility and a higher quality of life than the two main alternatives, dopamine agonists (DA) and monoamine oxidase type B inhibitors (MAOBI), according to the largest-ever trial of PD treatment (PD MED), published in The Lancet. [More]
REM sleep disorder: A sign of impending neurodegenerative disease

REM sleep disorder: A sign of impending neurodegenerative disease

How many millions of people suffer from sleep disturbance? One sleep disorder in particular, called REM behavior disorder, could be a sign of impending neurodegenerative disease, including Parkinson's and dementia, say scientists presenting their research at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting. [More]
Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science. [More]

Dopamine transporter availability predicts ICDs

Reduced striatal dopamine transporter availability is already present in patients with Parkinson’s disease who go on to develop impulse control disorders, a study shows. [More]
Newron Pharmaceuticals submits safinamide NDA to FDA

Newron Pharmaceuticals submits safinamide NDA to FDA

Newron Pharmaceuticals S.p.A. ("Newron"), a research and development company focused on novel CNS and pain therapies, and its partner Zambon S.p.A., an international pharmaceutical company strongly committed to the CNS therapeutic area with a long experience in respiratory disease therapies, woman care and primary care, announce that the New Drug Application (NDA) for safinamide was submitted today to the US Food and Drug Administration (FDA). [More]