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Characterized by itchiness, redness and thickening of the skin, eczema is often associated with elevated levels of immunoglobulin E (IgE) and a personal or family history of allergies, allergic rhinitis and asthma. The chronic disease affects approximately 15 million people in the United States. While topical corticosteroids are currently used to treat eczema, their chronic use is limited due to the potential for significant side effects. Topical calcineurin inhibitors have also shown potential in the treatment of this disease; however these potent immunosuppressive agents have yet to produce long-term safety data. In preclinical studies, NF-kB Decoy was efficiently delivered to intact skin using several easy-to-manufacture, inexpensive formulations and was effective in reducing the swelling and inflammation associated with eczema with minimal side effects. Clinical trials will demonstrate whether results obtained in preclinical studies will be indicative of future results.
Swedish researchers report simple habit to protect against allergy development in children

Swedish researchers report simple habit to protect against allergy development in children

Allergies are very common in industrialized countries. It has been suggested that exposure to harmless bacteria during infancy may be protective against the development of allergy. However, it has been difficult to pinpoint which bacteria a baby should be exposed to, and at what time and by which route this exposure should ideally occur. [More]

Children born outside U.S. have lower prevalence of allergic disease

A study by Jonathan I. Silverberg, M.D., Ph.D., M.P.H., of St. Luke's—Roosevelt Hospital Center, New York, and colleagues suggests children living the in the United States but born outside the U.S. have a lower prevalence of allergic disease that increases after residing in the United States for one decade. [More]
SLU study reveals that access to dermatologists limited for Medicaid-insured children with eczema

SLU study reveals that access to dermatologists limited for Medicaid-insured children with eczema

A recent Saint Louis University study revealed that Medicaid-insured children with eczema, an inflammatory skin condition that affects 20 percent children in the United States, do not have easy access to dermatologists. [More]
Genes play role in wound healing, regulate biological processes in human skin

Genes play role in wound healing, regulate biological processes in human skin

Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur. [More]
Experts and patients share tips on preventing skin cancer

Experts and patients share tips on preventing skin cancer

Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives. It's also one of the most preventable types of cancers. [More]
Researchers studying lipids to learn more about normal, abnormal biology

Researchers studying lipids to learn more about normal, abnormal biology

When you have your cholesterol checked, the doctor typically gives you levels of three fats found in the blood: LDL, HDL and triglycerides. But did you know your body contains thousands of other types of fats, or lipids? [More]

Research: Skin's immune cell plays a role in fighting off parasitic invaders

Sydney researchers have discovered a new type of immune cell in skin that plays a role in fighting off parasitic invaders such as ticks, mites, and worms, and could be linked to eczema and allergic skin diseases. [More]
Fruit fly study offers clues to wound healing

Fruit fly study offers clues to wound healing

A person's skin and a fruit fly's exoskeleton, called a "cuticle" may not look alike, but both coverings protect against injury, infection, and dehydration. [More]
Duration and exclusivity of infant breastfeeding does not prevent overweight or obesity: Study

Duration and exclusivity of infant breastfeeding does not prevent overweight or obesity: Study

In research that included nearly 14,000 healthy infants in Belarus, an intervention that succeeded in improving the duration and exclusivity of breastfeeding during infancy did not result in a lower risk of overweight or obesity among the children at age 11.5 years, according to a study appearing in the March 13 issue of JAMA. [More]

Halometasone and fusidic acid optimal for infected eczema

Results from a randomized, open-label phase III trial suggest that a combination cream of halometasone and fusidic acid reduces symptoms of eczema to a similar degree to a betamethasone and neomycin sulphate cream, but is more effective at treating infected lesions. [More]
Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Sanofi and Regeneron Pharmaceuticals, Inc. today announced that pooled data from two Phase 1b trials with dupilumab (REGN668/SAR231893), an investigational, high-affinity, subcutaneously administered, fully-human antibody targeting the alpha subunit of the interleukin 4 receptor (IL-4R alpha), were presented at the 71st Annual Meeting of the American Academy of Dermatology (AAD) in Miami. [More]
Santarus launches UCERIS for induction of remission in patients with ulcerative colitis

Santarus launches UCERIS for induction of remission in patients with ulcerative colitis

Santarus, Inc. announced today the U.S. commercial launch of UCERIS (budesonide) extended release tablets for the induction of remission in patients with active, mild to moderate ulcerative colitis. [More]
Innate lymphoid cells may be new therapeutic target in treating atopic dermatitis

Innate lymphoid cells may be new therapeutic target in treating atopic dermatitis

The increasing incidence of allergic skin diseases, and the accompanying economic burden and heightened risk of developing other allergic conditions, have spurred researchers to look for better ways to control these immune system-based disorders. [More]

New insight into eczema’s itch

Research shows that innate lymphoid cells accumulate in active eczema lesions and may contribute to disease progression. [More]

Asthma linked to atopic dermatitis persistence

Asthma is associated with rash persistence in children with atopic dermatitis, US researchers report. [More]
Children with eczema have distinct gut microbiome

Children with eczema have distinct gut microbiome

Infants with eczema have more diverse total gut microbiota than those without the skin condition, show study findings. [More]

Diet plays key role in severe childhood allergic disorders

Study findings suggest that children and adolescents who eat fast food three times a week or more have a greater risk for severe asthma, rhinoconjunctivitis, and eczema than those who do not. [More]
FDA approves Santarus’ UCERIS for induction of remission in patients with ulcerative colitis

FDA approves Santarus’ UCERIS for induction of remission in patients with ulcerative colitis

Santarus, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved UCERIS (budesonide) extended release tablets for the induction of remission in patients with active, mild to moderate ulcerative colitis. [More]

No link between gas cooking and asthma, allergies

Research suggests that exposure to gas cooking does not increase a child’s risk for asthma and other allergic conditions. [More]

Easy ways to prevent dry skin

What do cleansers, alcohol and coffee have in common? They are the worst enemies of your skin during winter, sucking out the moisture from your skin and making it extremely dry and itchy. [More]