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Emphysema is a debilitating disease that afflicts more than three million Americans. The disease is caused primarily by smoking and leads to a progressive, irreversible breakdown of lung tissue. This breakdown reduces the amount of lung tissue available for gas exchange and also impairs the lung's ability to inflate and deflate normally. As the disease advances, the most damaged areas of the lung over inflate within the chest cavity, trapping air and preventing the healthier lung areas from functioning normally. Eventually breathing becomes more difficult, leaving patients constantly feeling out-of-breath.

Researchers discover tumor suppressor gene folliculin essential to normal lung function in BHD patients

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys. [More]

Researchers discover mechanism that control normal lung function in patients with BHD syndrome

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys. Folliculin's absence or mutated state has a cascading effect that leads to deteriorated lung integrity and an impairment of lung function, as reported in their findings in the current issue of Cell Reports. [More]

Improving coordination of care for elderly patients trims costs and complications

Improving the coordination of care for elderly patients with chronic diseases trims costs, reduces use of health services and cuts complications, according to a new RAND Corporation study. [More]
Scientists find certain species of nontuberculous mycobacteria in water that cause infection in humans

Scientists find certain species of nontuberculous mycobacteria in water that cause infection in humans

Brisbane's water supply has been found to contain disease carrying bugs which can be directly linked to infections in some patients, according to a new study by QUT. [More]

COPD sufferers can reduce risk of being hospitalized by walking 3 kilometers a day

New research in Respirology shows that suffers of Chronic obstructive pulmonary disease (COPD) can reduce their risk of being hospitalized with severe attacks, by maintaining an exercise regime of walking between three to six kilometers a day. [More]
Cutting back on cigarette smoking linked to improved mental health outcomes

Cutting back on cigarette smoking linked to improved mental health outcomes

Health professionals who treat people with psychiatric problems often overlook their patients' smoking habits, assuming it's best to tackle depression, anxiety or substance abuse problems first. [More]
Ario Pharma begins XEN-0501 Phase IIa study for treatment persistent cough in COPD patients

Ario Pharma begins XEN-0501 Phase IIa study for treatment persistent cough in COPD patients

Ario Pharma Ltd, the Cambridge biopharmaceutical company developing innovative new approaches to treat respiratory disease, announced today that it has commenced a Phase IIa study of its TRPV1 antagonist, XEN-0501, for the treatment and prevention of cough in patients with chronic obstructive pulmonary disease (COPD). Persistent cough in COPD and other respiratory conditions present as a huge unmet medical need, with novel therapies urgently needed to improve the quality of life of patients. [More]
G. Alexander Patterson honored with 2014 Earl Bakken Scientific Achievement Award

G. Alexander Patterson honored with 2014 Earl Bakken Scientific Achievement Award

The Society of Thoracic Surgeons today awarded G. Alexander Patterson, MD with the 2014 Earl Bakken Scientific Achievement Award during the Society's 50th Annual Meeting. [More]
Idiopathic pulmonary fibrosis (IPF) and herpesvirus saimiri: an interview with Elazar Rabbani, Chief Executive Officer of Enzo

Idiopathic pulmonary fibrosis (IPF) and herpesvirus saimiri: an interview with Elazar Rabbani, Chief Executive Officer of Enzo

Pulmonary fibrosis is a condition where fibrotic or scarred tissue progressively develops in the lungs. In some cases the particular cause is known but in others it remains unknown and is given the term “idiopathic”. [More]
Smoking and cancer: an interview with Dr. Lewis Foxhall, VP of Health Policy, University of Texas MD Anderson Cancer Center

Smoking and cancer: an interview with Dr. Lewis Foxhall, VP of Health Policy, University of Texas MD Anderson Cancer Center

The report Smoking and Health: Report of the Advisory Committee to the Surgeon General, identified tobacco as the predominant cause of lung cancer in men. This was the first widely disseminated report based on scientific studies showing the clear link between smoking tobacco and serious health conditions including cancer, chronic lung diseases and heart disease. [More]
UMMS researchers commissioned by Alpha-1 Project to develop PiZ antibody

UMMS researchers commissioned by Alpha-1 Project to develop PiZ antibody

Researchers at the University of Massachusetts Medical School (UMMS) have been commissioned by the Alpha-1 Project (TAP) to develop a PiZ antibody. The antibody will be used to track the presence of mutant alpha-1 PiZ protein in human blood serum, an essential tool in testing potential therapies for Alpha-1 Antitrypsin Deficiency (Alpha-1). [More]
Scientists discover new class of cells expressing olfactory receptors in human airways

Scientists discover new class of cells expressing olfactory receptors in human airways

Your nose is not the only organ in your body that can sense cigarette smoke wafting through the air. Scientists at Washington University in St. Louis and the University of Iowa have showed that your lungs have odor receptors as well. [More]

Researchers work on breathalyser device to detect early signs of cancer

Researchers at the University of Huddersfield are working on a breathalyser device that will be able to detect very early signs of cancer, making a cure much more likely. [More]
Study finds that people with COPD twice likely to develop mild cognitive impairment, memory loss

Study finds that people with COPD twice likely to develop mild cognitive impairment, memory loss

A recent Mayo Clinic study found that people with chronic obstructive pulmonary disease (COPD) are about twice as likely to develop mild cognitive impairment (MCI) -- and chances are that it will include memory loss. The study was recently published in Mayo Clinic Proceedings. [More]
Lung volume reduction surgery: A great option for patients with severe emphysema

Lung volume reduction surgery: A great option for patients with severe emphysema

Every time Susan Fischer sees someone lugging around an oxygen container, she wants to pull them aside and tell them, "It can get better." [More]
BAL findings boost non-smoking COPD distinction

BAL findings boost non-smoking COPD distinction

Research shows that smoking status, and not airway obstruction, determines the distribution of T cell subsets in bronchoalveolar lavage in patients with chronic obstructive pulmonary disease. [More]

Chronic bronchitis could indicate COPD subtype

Chronic bronchitis is common among patients with chronic obstructive disease and may represent a subtype of the disease that places patients at risk for increased severity and exacerbations, say researchers. [More]

Smokers who quit faster may be able to lower risk of cardiovascular disease-related deaths

Cigarette smokers who are over 65 years of age may be able to lower their risk of cardiovascular disease-related deaths to the level of never-smokers when they quit faster than previously reported, according to research presented at the American Heart Association's Scientific Sessions 2013. [More]

Metal coil therapy may provide same benefits as major surgery for COPD

Brown was diagnosed with COPD and emphysema, the third leading cause of death in the United States, only behind heart disease and cancer. Right now, the only studied interventions that prolong life for patients with severe COPD are supplemental oxygen in people with low oxygen levels and lung volume reduction surgery (LVRS) in appropriately selected individuals. Like most COPD patients, Brown was given medication but told there was no cure. He was 58 years old. [More]
Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Extract taken from an Asian vegetable may have therapeutic qualities to treat head and neck cancer, a Saint Louis University researcher has found. [More]