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Estrogens are a family of related molecules that stimulate the development and maintenance of female characteristics and sexual reproduction.

The natural estrogens produced by women are steroid molecules, which means that they are derived from a particular type of molecular skeleton containing four rings of carbon atoms, giving the shape shown here. The most prevalent forms of human estrogen are estradiol and estrone. Both are produced and secreted by the ovaries, although estrone is also made in the adrenal glands and other organs.
Study finds alcohol consumption has no impact on mortality of breast cancer survivors

Study finds alcohol consumption has no impact on mortality of breast cancer survivors

Although previous research has linked alcohol consumption to an increased risk of developing breast cancer, a new study has found that drinking before and after diagnosis does not impact survival from the disease. [More]
Research: Paragazole makes triple-negative breast cancer cells express estrogen receptors

Research: Paragazole makes triple-negative breast cancer cells express estrogen receptors

Breast cancers that lack estrogen receptors are more difficult to treat than ER+ cancers. Research presented at the AACR Annual Meeting 2013 demonstrates an investigational drug, Paragazole, that makes triple-negative breast cancer cells express estrogen receptors, and that increases the sensitivity of these cells to chemotherapy. [More]
American Cancer Society announces new research, training grants for fiscal year 2013

American Cancer Society announces new research, training grants for fiscal year 2013

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 175 national research and training grants totaling $79,073,250 for fiscal year 2013. [More]
Overexpression of miR-155 promotes growth of blood vessels in tumors and metastasis

Overexpression of miR-155 promotes growth of blood vessels in tumors and metastasis

Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. [More]
Discovery of new signalling pathway creates hope for hormone therapy resistance

Discovery of new signalling pathway creates hope for hormone therapy resistance

A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant. [More]
New research shows surgical menopause increases cognitive decline and dementia

New research shows surgical menopause increases cognitive decline and dementia

Women who abruptly and prematurely lose estrogen from surgical menopause have a two-fold increase in cognitive decline and dementia. [More]
Study shows hormonal therapy increases risk of breast cancer

Study shows hormonal therapy increases risk of breast cancer

The study Dr. Chlebowski authored reported that estrogen plus progestin use is linked with increased breast cancer incidence. In addition, it said the prognosis is similar for both users and nonusers of combined hormone therapy, suggesting that mortality from breast cancer may be higher for hormone therapy users as well. [More]
FDA approves Teva's Quartette tablets for prevention of pregnancy

FDA approves Teva's Quartette tablets for prevention of pregnancy

Teva Pharmaceutical Industries Ltd. today announced that the U.S. Food and Drug Administration has approved Quartette (levonorgestrel/ethinyl estradiol and ethinyl estradiol) tablets for the prevention of pregnancy. [More]
Exposure to multiple estrogen-mimicking chemicals distorts hormone action

Exposure to multiple estrogen-mimicking chemicals distorts hormone action

For years, scientists have been concerned about chemicals in the environment that mimic the estrogens found in the body. In study after study, researchers have found links between these "xenoestrogens" and such problems as decreased sperm viability, ovarian dysfunction, neurodevelopmental deficits and obesity. [More]

Study: Hormone-therapy-related breast cancer cells can be attacked by cancer therapies

More than 100 women per day die from breast cancer in the United States. The odds of developing breast cancer increase for women taking hormone replacement therapy to avoid the effects of menopause. [More]
Study indicates link between estrogen and body fat storage

Study indicates link between estrogen and body fat storage

Women tend to carry excess fat in their hips and thighs, while men tend to carry it on their stomachs. But after menopause, things start to change: many women's fat storage patterns start to resemble those of men. [More]

University of Maryland scientist selected as fellow of newly created AACR Academy

Angela H. Brodie, Ph.D., a University of Maryland scientist whose research paved the way for a new class of drugs widely used to treat breast cancer patients around the world, has been selected by the American Association for Cancer Research as a fellow of the newly created AACR Academy. [More]
Biological markers for triple-negative breast cancer (TNBC): an interview with Alexandre Templier, CEO of Quinten

Biological markers for triple-negative breast cancer (TNBC): an interview with Alexandre Templier, CEO of Quinten

Triple negative breast cancer (TNBC) is a type of cancer that has none of the three markers that are currently used for targeted chemotherapy. These markers are estrogen receptor (ER), progesterone receptor (PR) and HER2. [More]
Study suggests possibility of engineering artificial ovaries in lab

Study suggests possibility of engineering artificial ovaries in lab

A proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women. [More]

Scientists discover novel compounds that can lead to new strategies for treating diseases

Using a broad spectrum of analytical tools, scientists from the Florida campus of The Scripps Research Institute have uncovered a class of novel compounds that can alter cell signaling activity, resulting in a variety of responses including a strong anti-inflammatory effect. [More]
Women over 40 need to be vigilant about contraception even in perimenopause

Women over 40 need to be vigilant about contraception even in perimenopause

Women reaching the age of 40 tend to be less vigilant about birth control because they think the risk of pregnancy is low - or that birth control can cause health problems - but a review of the evidence by a team that includes a Women & Infants Hospital of Rhode Island physician recently underscored the need to be vigilant about contraception even in perimenopause. [More]
High soy consumption improves overall survival in women with lung cancer

High soy consumption improves overall survival in women with lung cancer

New results from a large observational follow-up study conducted in Shanghai, China, indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy. [More]
Estrogen therapy keeps joint pain at bay post hysterectomy

Estrogen therapy keeps joint pain at bay post hysterectomy

Estrogen therapy can help keep joint pain at bay after menopause for women who have had a hysterectomy. Joint pain was modestly, but significantly, lower in women who took estrogen alone than in women who took placebo in the Women's Health Initiative (WHI) trial. [More]

Estrogen provides long-term relief for post-menopausal women suffering from joint pain

Post-menopausal women, who often suffer from joint pain, could find some long-term relief by taking estrogen-only medication, according to a new study based on the Women's Health Initiative (WHI) that was released online today by the journal, Menopause. [More]
Study finds that some younger women see both benefit and harm from annual exams

Study finds that some younger women see both benefit and harm from annual exams

Screening for breast cancer every two years appears just as beneficial as yearly mammograms for women ages 50 to 74, with significantly fewer "false positives" - even for women whose breasts are dense or who use hormone therapy for menopause. [More]