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Estrogens are a family of related molecules that stimulate the development and maintenance of female characteristics and sexual reproduction.

The natural estrogens produced by women are steroid molecules, which means that they are derived from a particular type of molecular skeleton containing four rings of carbon atoms, giving the shape shown here. The most prevalent forms of human estrogen are estradiol and estrone. Both are produced and secreted by the ovaries, although estrone is also made in the adrenal glands and other organs.
Telephone-based weight loss intervention is effective in breast cancer treatments

Telephone-based weight loss intervention is effective in breast cancer treatments

A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese, published online today in Journal of Clinical Oncology by Dr. Pamela Goodwin of Mount Sinai Hospital and the Lunenfeld-Tanenbaum Research Institute. [More]
New driver of atherosclerosis may prove to be promising therapeutic target

New driver of atherosclerosis may prove to be promising therapeutic target

A new driver of atherosclerosis has been identified by researchers at UT Southwestern Medical Center. This molecule, known as 27HC (27-hydroxycholesterol), has been found to exacerbate the development of the condition, and may prove to be a promising therapeutic target. [More]
New approach promises better drugs for diabetes and osteoporosis

New approach promises better drugs for diabetes and osteoporosis

By swapping replacement parts into the backbone of a synthetic hormone, UW-Madison graduate student Ross Cheloha and his mentor, Sam Gellman, along with collaborators at Harvard Medical School, have built a version of a parathyroid hormone that resists degradation in laboratory mice. [More]
Compound developed as cholesterol-fighting molecule can kill cancerous cells

Compound developed as cholesterol-fighting molecule can kill cancerous cells

Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of breast cancer, but also can kill the cancerous cells. [More]
Researchers find no evidence of protective link between soy food and endometrial cancer risk

Researchers find no evidence of protective link between soy food and endometrial cancer risk

Researchers have found no evidence of a protective association between soy food and endometrial cancer risk, says a new study published (18 June) in BJOG: An International Journal of Obstetrics and Gynaecology. [More]
Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences, have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer. [More]
Childhood oestrogen may normalise thelarche in Turner syndrome

Childhood oestrogen may normalise thelarche in Turner syndrome

Treating girls with Turner syndrome with low-dose oestrogen from childhood results in earlier thelarche and a slower tempo of puberty, research shows. [More]
Researchers examine role of female sex hormones in male obesity

Researchers examine role of female sex hormones in male obesity

An imbalance of female sex hormones among men in Western nations may be contributing to high levels of male obesity, according to new research from the University of Adelaide. [More]
Lifestyle changes, natural supplements can help women fight weight gain during menopause

Lifestyle changes, natural supplements can help women fight weight gain during menopause

Menopause, which tends to occur in midlife, is often known for causing weight gain. Menopausal weight gain is frequently caused by the hormonal changes that occur as the ovaries slow their production of estrogen and progesterone. [More]
New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments. [More]
New targets found for potential intervention in breast cancer

New targets found for potential intervention in breast cancer

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments. [More]
Macrophages present in shed endometrium may contribute to lesion formation, shows study

Macrophages present in shed endometrium may contribute to lesion formation, shows study

A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology. [More]
Scientists define genetic cause for two types of birth defects in newborn boys

Scientists define genetic cause for two types of birth defects in newborn boys

Baylor College of Medicine scientists defined a previously unrecognized genetic cause for two types of birth defects found in newborn boys, described in a report published today in the journal Nature Medicine. [More]
Goserelin can help reduce risk of early menopause in young women with breast cancer

Goserelin can help reduce risk of early menopause in young women with breast cancer

Among young women treated for breast cancer, one of the most distressing side effects of chemotherapy is early menopause. [More]
New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

New data highlights molecular profiling in guiding treatment of patients with gynecologic malignancies

Caris Life Sciences®, a leading biosciences company focused on fulfilling the promise of precision medicine, announced today the presentation of clinical data from studies demonstrating the potential utility of comprehensive molecular profiling in guiding treatment of patients with gynecologic malignancies, including breast cancers and ovarian cancer. [More]
Gene regulation responsible for normal breast tissue may also play role in cancer development

Gene regulation responsible for normal breast tissue may also play role in cancer development

About one in eight women in the United States will contract breast cancer in her lifetime. Now new research from Tel Aviv University-affiliated researchers, in collaboration with Johns Hopkins University, has provided another tool to help women, clinicians, and scientists searching for a cure to the one of the most widespread yet incurable diseases on the planet. [More]
Findings may help medical researchers identify effective drug targets for triple negative breast cancer

Findings may help medical researchers identify effective drug targets for triple negative breast cancer

The suppression of two genes reduce breast cancer tumor formation and metastasis by interfering with blood vessel formation and recruitment, report scientists from Houston Methodist and five other institutions in the Proceedings of the National Academy of Sciences (now online). [More]
Study detects hormone receptor's key role in normal organ development and function

Study detects hormone receptor's key role in normal organ development and function

A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function. [More]
Study reveals loss of function of gene RARRES3 in breast cancer cells promotes metastasis to lung

Study reveals loss of function of gene RARRES3 in breast cancer cells promotes metastasis to lung

A study published today in EMBO Molecular Medicine reveals that the loss of function of the gene RARRES3 in breast cancer cells promotes metastasis to the lung. [More]
Estrogen therapy and venlafaxine treatment effective for hot flashes, night sweats

Estrogen therapy and venlafaxine treatment effective for hot flashes, night sweats

A new research study from Brigham and Women's Hospital (BWH) that compares low-dose oral estrogen and low-dose non-hormonal venlafaxine hydrochloride extended release (XR) to placebo were both found effective in reducing the number of hot flashes and night sweats reported by menopausal women. [More]