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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Neural stem cells from T cell-derived iPSCs provide neurological disease model

Neural stem cells from T cell-derived iPSCs provide neurological disease model

Researchers in Japan report that neural stem cells derived from readily available T cell-derived iPSCs provide a neurological disease model when cultured in a novel protocol developed by them. The findings are important for the treatment of Parkinson’s disease and are published in Stem Cell Reports, March 2016. [More]
Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibiting the transfer of calcium ions into the cell's powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania. [More]
Healthy cells actively collaborate with tumours to promote growth of new blood vessels

Healthy cells actively collaborate with tumours to promote growth of new blood vessels

Healthy cells actively collaborate with tumours by creating a mesh of collagen that encourages cancer cells to build new blood vessels, a new study shows. [More]
Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Scientists find that lifespan of supportive cells in tumor may control cancer metastasis

Researchers have discovered that eliminating cells thought to aid tumor growth did not slow or halt the growth of cancer tumors. In fact, when the cancer-associated fibroblasts (CAFs), were eliminated after 10 days, the risk of metastasis of the primary tumor to the lungs and bones of mice increased dramatically. [More]
LMU researchers reveal how crystalline deposits induce cell death

LMU researchers reveal how crystalline deposits induce cell death

Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now elucidated how the insoluble deposits induce cell death. [More]
Amarantus seeks FDA's Rare Pediatric Disease Designation and ODD to treat GCMN with Engineered Skin Substitute

Amarantus seeks FDA's Rare Pediatric Disease Designation and ODD to treat GCMN with Engineered Skin Substitute

Amarantus BioScience Holdings, Inc., a biotechnology company focused on developing products for Regenerative Medicine, Neurology and Orphan Diseases, announced that it has requested Rare Pediatric Disease Designation (RPDD) and Orphan Drug Designation (ODD) from the US Food and Drug Administration to treat GCMN with Engineered Skin Substitute (ESS). [More]
Researchers identify liver-derived hormone that regulates sugar intake

Researchers identify liver-derived hormone that regulates sugar intake

We all love our sugar, especially during the holidays. Cookies, cake, and candy are simply irresistible. While sugar cravings are common, the physiological mechanisms that trigger our "sweet tooth" are not well defined. [More]
UB study traces how enigmatic molecules help cancer self-destruct

UB study traces how enigmatic molecules help cancer self-destruct

You've probably never heard of "sphingolipids" before. But these curiously named organic compounds play a vital role in one of humanity's most well-known diseases: cancer. [More]
Chi-Med announces initiation of Phase III sulfatinib registration trial in patients with NETs in China

Chi-Med announces initiation of Phase III sulfatinib registration trial in patients with NETs in China

Hutchison China MediTech Limited today announces that Hutchison MediPharma Limited, its drug R&D subsidiary, has initiated SANET-ep, a Phase III sulfatinib (HMPL-012) registration trial in China in patients with extra-pancreatic neuroendocrine tumors ("NETs"), which are all non-pancreatic NETs, including, for example, NETs originating in the lymph, lung and across the gastrointestinal tract. [More]
AACR rapid and dramatic responses in TRK fusion patients

AACR rapid and dramatic responses in TRK fusion patients

Loxo Oncology, Inc., a biopharmaceutical company innovating the development of highly selective medicines for patients with genetically defined cancers, today announced new results from its Phase 1 open-label, dose-escalation trial of LOXO-101, a selective inhibitor of tropomyosin receptor kinase (TRK) signaling molecules, and the first preclinical data for its RET and FGFR programs. The data are being presented at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston. [More]
Hutchison MediPharma begins sulfatinib Phase I trial in US

Hutchison MediPharma begins sulfatinib Phase I trial in US

Hutchison China MediTech Limited today announces that Hutchison MediPharma Limited ("HMP"), its drug R&D subsidiary, has initiated the Phase I clinical trial of sulfatinib (HMPL-012) in the United States. [More]
CV risk assessment essential for CML TKI trial design

CV risk assessment essential for CML TKI trial design

The risk and impact of cardiovascular adverse events in long-term users of tyrosine kinase inhibitors for chronic myeloid leukaemia is highlighted in a review published in the Journal of Clinical Oncology. [More]
Roche to acquire biotechnology company, Adheron Therapeutics

Roche to acquire biotechnology company, Adheron Therapeutics

Adheron Therapeutics, a privately held biotechnology company based in Berkeley, California, United States, announced today that it has agreed to be acquired by Roche. [More]
New genetic cause identified for congenital heart arrhythmia

New genetic cause identified for congenital heart arrhythmia

Scientists at The Ohio State University Dorothy M. Davis Heart and Lung Research Institute have identified a new genetic cause for congenital heart arrhythmia. The results of their research are published online by the Proceedings of the National Academy of Sciences (PNAS). [More]
New findings on amitriptyline drug could help develop antidepressants with novel mechanisms

New findings on amitriptyline drug could help develop antidepressants with novel mechanisms

Researchers in Japan have shown that several different classes of antidepressants increase early growth responses in astrocytes, star-shaped glial cells, which could help develop new treatments. [More]
Inhibition of FGFR3 receptor could be a new way of treating patients with liver cell cancer

Inhibition of FGFR3 receptor could be a new way of treating patients with liver cell cancer

In a recent study, scientists from the Institute for Cancer Research at MedUni Vienna have shown that the growth factor receptor FGFR3 increases the rate of growth and aggressiveness of hepatocellular carcinomas (liver cell cancer). Inhibition of this receptor could be a new and effective way of treating patients. [More]
FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

FGF21 compound in breast milk plays key role in neonatal nutrient absorption, intestinal function

A compound found in breast milk, named fibroblast growth factor 21 (FGF21), plays a key role in neonatal nutrient absorption and intestinal function. FGF21 also contributes to improve newborn growth and metabolic profile. [More]
New study reveals effect of diabetes drug on bone health, benefit of exercise in mice

New study reveals effect of diabetes drug on bone health, benefit of exercise in mice

Inside our bones there is fat. Diabetes increases the amount of this marrow fat. And now a study from the UNC School of Medicine shows how some diabetes drugs substantially increase bone fat and thus the risk of bone fractures. [More]
Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers have determined how the most common gene mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disrupts normal cell function, providing insight likely to advance efforts to develop targeted therapies for these brain diseases. [More]
FGF protein may play key role in breast and prostate cancer, shows research

FGF protein may play key role in breast and prostate cancer, shows research

Simply put, cancer is caused by mutations to genes within a cell that lead to abnormal cell growth. Finding out what causes that genetic mutation has been the holy grail of medical science for decades. [More]
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