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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
ArQule reports net loss of $7,141,000 in first quarter 2014

ArQule reports net loss of $7,141,000 in first quarter 2014

ArQule, Inc. today announced its financial results for the first quarter of 2014. For the quarter ended March 31, 2014, the Company reported a net loss of $7,141,000 or $0.11 per share, compared to a net loss of $5,775,000, or $0.09 per share, for the first quarter of 2013. [More]
Study: Functional electrical stimulation promotes neural cell proliferation in brains of rats with cerebral infarction

Study: Functional electrical stimulation promotes neural cell proliferation in brains of rats with cerebral infarction

Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, Dr. Yun Xiang and co-workers from Sun Yat-sen University in China observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. [More]
Cook Medical launches Stemulate Pooled Human Platelet Lysate cell culture media supplement

Cook Medical launches Stemulate Pooled Human Platelet Lysate cell culture media supplement

Cook Medical will introduce its Stemulate Pooled Human Platelet Lysate cell culture media supplement at the 2014 International Society for Cellular Therapy meeting, April 23-26. [More]
Fibroblasts could offer alternative to heart transplants for patients with heart disease

Fibroblasts could offer alternative to heart transplants for patients with heart disease

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease. [More]
Sprifermin reduces cartilage loss in patients with knee osteoarthritis

Sprifermin reduces cartilage loss in patients with knee osteoarthritis

In a new study in patients with osteoarthritis (OA) of the knee, at 12 months, total femorotibial cartilage thickness loss was reduced in sprifermin (recombinant human fibroblast growth factor 18)-treated knees compared to placebo-treated knees, with effects being significant in the lateral femorotibial compartment but not in the central femorotibial compartment. [More]
Genkyotex’s GKT137831 reverses lung fibrosis in new model of idiopathic pulmonary fibrosis

Genkyotex’s GKT137831 reverses lung fibrosis in new model of idiopathic pulmonary fibrosis

Genkyotex, the leading developer of selective NOX enzyme inhibitors, announced today the publication of data showing that GKT137831, a first in class NOX1 and 4 inhibitor, was able to reverse lung fibrosis associated with aging in a new model of idiopathic pulmonary fibrosis. [More]
Study identifies two cell surface receptors that may be responsible for spread of lung cancer

Study identifies two cell surface receptors that may be responsible for spread of lung cancer

Two cell surface receptors might be responsible for the most common form of lung cancer spreading to other parts of the body, according to a study led by the Translational Genomics Research Institute. [More]
Eli Lilly presents early-stage data from several targeted cancer therapies at AACR 2014

Eli Lilly presents early-stage data from several targeted cancer therapies at AACR 2014

Eli Lilly and Company will present early-stage data from several targeted cancer therapies – including bemaciclib "beh meh sye' klib" (LY2835219), its oral, cell-cycle inhibitor of CDK4/6 – that make up its diverse clinical oncology pipeline during the American Association for Cancer Research (AACR) Annual Meeting 2014 held in San Diego, Calif. from April 5 – 9. [More]
Novartis to present early stage data on 19 investigational compounds at AACR annual meeting

Novartis to present early stage data on 19 investigational compounds at AACR annual meeting

Novartis announced today that early stage data on 19 investigational compounds in its oncology pipeline will be presented at the annual meeting of the American Association of Cancer Research, April 5-9, 2014 in San Diego, CA. [More]
New way to make large concentrations of skeletal muscle cells from human stem cells

New way to make large concentrations of skeletal muscle cells from human stem cells

As stem cells continue their gradual transition from the lab to the clinic, a research group at the University of Wisconsin-Madison has discovered a new way to make large concentrations of skeletal muscle cells and muscle progenitors from human stem cells. [More]
3-D imaging of two different mouse models helps understand Apert Syndrome development

3-D imaging of two different mouse models helps understand Apert Syndrome development

Three dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans. [More]
PBL Assay Science, HumanZyme ink licensing agreement to expand reagent offerings

PBL Assay Science, HumanZyme ink licensing agreement to expand reagent offerings

PBL Assay Science announces a licensing agreement with HumanZyme, Inc. (Chicago, USA) to expand reagent offerings. The agreement allows PBL to provide ~50 authentic human cell-expressed (HCE) cytokines and growth factors directly to scientists worldwide. [More]
Study points to unique therapeutic approach for managing muscle-wasting conditions

Study points to unique therapeutic approach for managing muscle-wasting conditions

New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study. [More]
Researchers personalize drug treatments for cholangiocarcinoma using genomic sequencing

Researchers personalize drug treatments for cholangiocarcinoma using genomic sequencing

Physicians at Mayo Clinic's Individualized Medicine Clinic and researchers at the Translational Genomics Research Institute (TGen) have personalized drug treatments for patients with cholangiocarcinoma using genomic sequencing technologies. [More]
Pancreatic stellate cells help pancreatic cancer grow and spread in cell hijack method

Pancreatic stellate cells help pancreatic cancer grow and spread in cell hijack method

Pancreatic stellate cells, which normally aid tissue repair, unwittingly help pancreatic cancer grow and spread in a method of 'cell hijack' only seen before in brain and breast cancer, according to new research from Queen Mary University of London. [More]
South Korean lung SCC genetic secrets revealed

South Korean lung SCC genetic secrets revealed

Close examination of DNA taken from squamous cell carcinoma of the lung in South Korean patients has identified a gene fusion that may be targeted by current treatments, scientists say. [More]
Rival proteins’ relative expression levels in cancer cells could be biomarkers for prognosis, treatment

Rival proteins’ relative expression levels in cancer cells could be biomarkers for prognosis, treatment

​Consider two drivers, each with a key that fits the same car. Driver 1 wants simply to turn on the ignition and leave the vehicle idling, ready and waiting to roll. Driver 2 wants to take it on a destructive joy ride. [More]
Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

A new study led by Boston University School of Medicine demonstrates that the abnormal metabolism linked to obesity could be regulated in part by the interaction of two metabolic regulators, called the NAD-dependent deacetylase SIRT1 and fibroblast growth factor 21 (FGF21). Using experimental models, the researchers found that a lack of SIRT1 protein in the liver led to lower levels of a liver secreted protein FGF21, which resulted in an increased likelihood of developing fatty liver disease and obesity. [More]
Research opens door to new direction of PAH treatment

Research opens door to new direction of PAH treatment

The development of new, more effective vasodilators to treat pulmonary arterial hypertension has been hampered because of their systemic toxicity and adverse side effects. An international team of investigators seeking to surmount these problems and increase drug efficacy have determined that a vascular homing peptide can selectively target hypertensive pulmonary arteries to boost the pulmonary but not systemic effects of vasodilators. Importantly for potential clinical use, this peptide retains its activity when given sublingually. The results using a rat model of PAH are published in the American Journal of Pathology. [More]
Researchers develop possible new method for treating pancreatic cancer

Researchers develop possible new method for treating pancreatic cancer

A possible new method for treating pancreatic cancer which enables the body's immune system to attack and kill cancer cells has been developed by researchers. [More]