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Finasteride is a synthetic antiandrogen which acts by inhibiting type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT). It is used as a treatment in benign prostatic hyperplasia (BPH) in low doses, and prostate cancer in higher doses. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.

"Hotline" report on finasteride for prevention of prostate cancer

20. November 2009 11:45
In response to a recent New York Times article that questions why currently available medications designed to treat and prevent some cancers are being ignored, ECRI Institute, an independent nonprofit organization, is offering a roadmap to the evidence on Finasteride for Prevention of Prostate Cancer for free download. [More]

Tips for treating age-related dermatologic concerns

11. November 2009 02:58
Everyone expects their bodies to change as they get older. From wrinkles and sagging skin to brittle bones and aches and pains, the aging process is inevitable. In addition, there are a number of medical dermatologic conditions that surface with age that can cause people even more stress. Fortunately, dermatologists can help diagnose and treat these conditions no matter when they strike. [More]

New tools needed to identify men and women at risk for the most aggressive cancers

21. October 2009 05:33
Twenty years of screening for breast and prostate cancer - the most diagnosed cancer for women and men - have not brought the anticipated decline in deaths from these diseases, argue experts from the University of California, San Francisco and the University of Texas Health Science Center at San Antonio in an opinion piece published in the "Journal of the American Medical Association." [More]

Symposium on genetics of psoriasis and psoriatic arthritis to be held

24. September 2009 06:36
A symposium about “Pharmacogenomics In Dermatology And Cosmetics” will be presented on Thursday, October 8 to coincide with the 18th European Academy of Dermatology and Venereology (EADV) Congress. It will be held at the Kempinski Hotel Bristol - Salon Charlottenburg-Cecilienhof, Kurfürstendamm 27, D-10719, Berlin, Germany. [More]

Prostate cancer: current evidence weighs against population screening

30. June 2009 04:28
The recent release of two large randomized trials suggests that if there is a benefit of screening, it is, at best, small, says a new report in CA: A Cancer Journal for Clinicians. [More]

Posted in: Medical Research News

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Selenium and vitamin E supplements do not prevent prostate cancer

28. October 2008 18:21
Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. [More]

Vitamin E and selenium do not prevent prostate cancer

28. October 2008 06:13
A major study on whether vitamin E and selenium prevent prostate cancer has been stopped because the supplements are not effective and also because there is a suspicion of a risk. [More]

Posted in: Men's Health News

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Finasteride for prostate cancer

19. May 2008 01:26
A comprehensive re-evaluation of the largest prostate cancer prevention study ever completed produced new findings suggesting that men and their doctors should consider a more aggressive approach that includes finasteride to prevent the development of prostate cancer. [More]

Posted in: Men's Health News

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Five-alpha-reductase Inhibitors for prostate cancer prevention

17. April 2008 22:32
Compared to placebo treatment, taking 5-alpha-reductase inhibitors (5-ARIs) can reduce a man's risk of being diagnosed with prostate cancer from around 5-9% to around 4-6% during up to 7 years of treatment, according to a new Cochrane Review. [More]

Posted in: Drug Trial News

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Heart-healthy diet may also be good for the prostate

14. February 2008 13:52
Men who eat a diet low in fat and red meat but high in vegetables and lean protein and who drink alcohol in moderation may not just be doing their hearts a favor. [More]

Pros, cons of finasteride to prevent prostate cancer should be considered

22. January 2008 03:22
Findings by UT Southwestern Medical Center researchers encourage men to weigh both the potential benefits and side effects of the drug finasteride before taking it to prevent prostate cancer. [More]

Posted in: Men's Health News

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Coping with urinary incontinence

26. September 2007 00:45
For older adults, increased urinary frequency is fairly common. [More]

Prostate cancer prevention: past, present, and future

25. September 2007 23:31
Recent investigations of medications, diet and the molecular understanding of prostate cancer are defining potential prevention strategies for the disease, and herald a new stage in the management of this cancer, according to a new review. [More]

Diet and medications may assist prevention of prostate cancer

25. September 2007 01:31
Recent investigations of medications, diet and the molecular understanding of prostate cancer are defining potential prevention strategies for the disease, and herald a new stage in the management of this cancer, according to a new review. [More]

Shrinkage of prostate led to overestimation of cancer risk in finasteride trial

13. September 2007 03:21
Reanalysis of data from the first long-term randomized trial of a chemopreventive agent for prostate cancer shows that the excess prevalence of high-grade prostate cancer in the drug-treated group may be attributable to shrinkage of the prostate at the time of biopsy. [More]
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