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A gene is a unit of heredity in a living organism. It normally resides on a stretch of DNA that codes for a type of protein or for an RNA chain that has a function in the organism. All living things depend on genes, as they specify all proteins and functional RNA chains.
Amgen seeks FDA approval for evolocumab to treat patients with high cholesterol

Amgen seeks FDA approval for evolocumab to treat patients with high cholesterol

Amgen today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration for evolocumab seeking approval for the treatment of high cholesterol. [More]
Mutant allele frequency predicts lung cancer TKI response

Mutant allele frequency predicts lung cancer TKI response

Tyrosine kinase inhibitor sensitivity may be predicted by the frequency of a point mutation in the epidermal growth factor receptor gene, suggests a study of Japanese patients with advanced lung adenocarcinoma. [More]
Gene variants linked to overactive bladder and prolapse in women

Gene variants linked to overactive bladder and prolapse in women

A systematic review and meta-analysis of genetic association studies reveals a number of genetic variations associated with overactive bladder and pelvic organ prolapse in women. [More]
High PD-L1 expression linked to reduced survival in NSCLC

High PD-L1 expression linked to reduced survival in NSCLC

Overexpression of programmed death-ligand 1 is independently associated with the presence of epidermal growth factor receptor gene mutations and poor prognosis in patients with non-small-cell lung cancer, Japanese researchers report. [More]
Scientists solve mystery of why specific signaling pathway can be linked with alcohol dependence

Scientists solve mystery of why specific signaling pathway can be linked with alcohol dependence

Scientists at The Scripps Research Institute (TSRI) have solved the mystery of why a specific signaling pathway can be associated with alcohol dependence. [More]
Scientists alter emotional associations of specific memories

Scientists alter emotional associations of specific memories

By manipulating neural circuits in the brain of mice, scientists have altered the emotional associations of specific memories. [More]
Research report: Orphan Diseases Partnering Terms and Agreements

Research report: Orphan Diseases Partnering Terms and Agreements

The Orphan Diseases Partnering Terms and Agreements report provides an understanding and access to the orphan diseases partnering deals and agreements entered into by the worlds leading healthcare companies. [More]
Report on Co-development Terms & Agreements in Pharma, Biotech and Diagnostics

Report on Co-development Terms & Agreements in Pharma, Biotech and Diagnostics

The Co-development Terms and Agreements in Pharma, Biotech and Diagnostics report provides comprehensive understanding and unprecedented access to the co-development deals and agreements entered into by the worlds leading life science companies. [More]
Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

Many African-Americans may not be getting effective doses of the HIV drug maraviroc, a new study from Johns Hopkins suggests. The initial dosing studies, completed before the drug was licensed in 2007, included mostly European-Americans, who generally lack a protein that is key to removing maraviroc from the body. [More]
Advanced statistical approach evaluates gene-environmental interactions that contribute to disease

Advanced statistical approach evaluates gene-environmental interactions that contribute to disease

Dartmouth cancer researchers developed and tested an advanced statistical model to evaluate the genetic and environmental interactions that contribute to disease as published yesterday in Human Genetics. [More]
Researchers help to gain greater insight into biological clock that sets pace for daily life

Researchers help to gain greater insight into biological clock that sets pace for daily life

Casey Diekman, assistant professor of mathematical sciences at New Jersey Institute of Technology (NJIT), is helping to gain greater insight into the biological clock that sets the pace for daily life. [More]
Versatile nanoparticles offer wide variety of diagnostic and therapeutic applications

Versatile nanoparticles offer wide variety of diagnostic and therapeutic applications

Kit Lam and colleagues from UC Davis and other institutions have created dynamic nanoparticles (NPs) that could provide an arsenal of applications to diagnose and treat cancer. [More]
Spanish scientists explore genetic basis of familial extreme longevity

Spanish scientists explore genetic basis of familial extreme longevity

In a recent report in Aging Cell, a multidisciplinary team of Spanish scientists, led by Tim Cash and Manuel Serrano at the Spanish National Cancer Research Centre, identify rare variants in the APOB gene in several families where exceptional longevity (>100 years of age) appears to cluster. [More]
Repurposing anti-depressant medication to target new pathway may help combat medulloblastoma

Repurposing anti-depressant medication to target new pathway may help combat medulloblastoma

An international research team reports in Nature Medicine a novel molecular pathway that causes an aggressive form of medulloblastoma, and suggests repurposing an anti-depressant medication to target the new pathway may help combat one of the most common brain cancers in children. [More]
Female rats whose great grandparents exposed to toxins become more vulnerable to stress

Female rats whose great grandparents exposed to toxins become more vulnerable to stress

Scientists have known that toxic effects of substances known as endocrine disrupting chemicals (EDCs), found in both natural and human-made materials, can pass from one generation to the next, but new research shows that females with ancestral exposure to EDC may show especially adverse reactions to stress. [More]
Researchers find why certain glioblastomas become drug resistance

Researchers find why certain glioblastomas become drug resistance

Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas - the primary form of a deadly brain cancer - are resistant to drug therapy. [More]
Researchers develop new integrated approach to pinpoint genetic "drivers" of cancer

Researchers develop new integrated approach to pinpoint genetic "drivers" of cancer

UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic "drivers" of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy. [More]
Study sheds light on direct causal relationship between smoking and mortality

Study sheds light on direct causal relationship between smoking and mortality

It is a fact that smoking is harmful and associated with deadly diseases such as cancer and cardiovascular disease. [More]
Finding suggests that retina acts as type of window to the brain

Finding suggests that retina acts as type of window to the brain

Researchers at the Gladstone Institutes and University of California, San Francisco have shown that a loss of cells in the retina is one of the earliest signs of frontotemporal dementia (FTD) in people with a genetic risk for the disorder-even before any changes appear in their behavior. [More]
Study finds a host of new clues on gene-environment interactions in Crohn's disease

Study finds a host of new clues on gene-environment interactions in Crohn's disease

A new study finds a wide range of epigenetic changes-alterations in DNA across the genome that may be related to key environmental exposures-in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America. [More]