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A gene is a unit of heredity in a living organism. It normally resides on a stretch of DNA that codes for a type of protein or for an RNA chain that has a function in the organism. All living things depend on genes, as they specify all proteins and functional RNA chains.
Northwestern Medicine investigators to lead clinical trial for people with rare cancers

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

A novel national trial for people with no established alternative to treat their rare cancers is being co-led by Northwestern Medicine investigators, who helped conceive of and develop the project. [More]
Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

Scientists have identified a 'molecular barcode' in the blood of patients with Ebola virus disease that can predict whether they are likely to survive or die from the viral infection. [More]
Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra LLC, a biotechnology company discovering therapies for Alzheimer’s disease and Parkinson’s disease announced the publication of the article “Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease” in Scientific Reports, a peer-reviewed journal of the Nature Publishing Group. [More]
New research provides insight into how estrogen modulates fear learning

New research provides insight into how estrogen modulates fear learning

Low estrogen levels may make women more susceptible to the development of post-traumatic stress disorder (PTSD) at some points in their menstrual cycles or lifetimes, while high estrogen levels may be protective. [More]
New way of repurposing existing drugs could unearth promising treatments for Parkinson’s disease

New way of repurposing existing drugs could unearth promising treatments for Parkinson’s disease

By bringing together cutting-edge stem cell technologies and computational biology, researchers at Oxford University have developed a unique way to identify existing drugs that could potentially be repurposed for treating Parkinson’s. [More]
‘Collateral lethality’ may create new therapeutic options for several cancers

‘Collateral lethality’ may create new therapeutic options for several cancers

Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as "collateral lethality," which may create new options for development of therapies for several cancers. [More]
OSU scientists develop new weapon to combat antibiotic-resistant germs

OSU scientists develop new weapon to combat antibiotic-resistant germs

Oregon State University researchers have developed a new weapon in the battle against antibiotic-resistant germs - a molecule that neutralizes the bugs' ability to destroy the antibiotic. [More]
Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

A five-year, $1.8 million grant (R01CA203965) from the National Cancer Institute awarded to Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, will support research to further elucidate the mechanisms behind the most frequently mutated gene in human tumors - p53. [More]
Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Neurodevelopmental disorders like autism very likely have their origin at the dawn of life, with the emergence of inappropriate connectivity between nerve cells in the brain. [More]
Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

UT Southwestern Medical Center researchers have uncovered the mechanism by which the stress hormone FGF21 keeps digestive enzymes from damaging the pancreas. [More]
Scientists unravel new genetic immunodeficiency that makes children vulnerable to mild illnesses

Scientists unravel new genetic immunodeficiency that makes children vulnerable to mild illnesses

A team of scientists led by prof. Adrian Liston and prof. Isabelle Meyts were able to characterize a new genetic immunodeficiency resulting from a mutation in a gene named STAT2. [More]
Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

An enzyme identified in Saccharomyces cerevisiae, commonly known as brewer's or baker's yeast, has passed in vitro trials, demonstrating its capacity to kill acute lymphoblastic leukemia (ALL) cells. [More]
Researchers identify brain cell types from cell culture of adult human neurons

Researchers identify brain cell types from cell culture of adult human neurons

Studying brain disorders in people and developing drugs to treat them has been slowed by the inability to investigate single living cells from adult patients [More]
Study finds link between obesity-related disease and epigenetic modifications

Study finds link between obesity-related disease and epigenetic modifications

Obesity has been linked to "letter" changes at many different sites in the genome, yet these differences do not fully explain the variation in people's body mass index (BMI) or why some overweight people develop health complications while others don't. [More]
Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Researchers at Trinity College Dublin have made exciting new findings that could offer a means of fighting resistance to treatment for people with oesophageal cancer. [More]
Study provides insights into CPEB4 gene and fatty liver disease

Study provides insights into CPEB4 gene and fatty liver disease

This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease. [More]
Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

Researchers from the Genes and Cancer research group at the Bellvitge Biomedical Research Institute have identified inactivating mutations in a number of genes that code for HLA-I histocompatibility complex proteins, which are involved in the immune response and can condition the tesponse of lung cancer patients to immunotherapy. [More]
People with metabolic syndrome may need more vitamin E, new research shows

People with metabolic syndrome may need more vitamin E, new research shows

New research has shown that people with metabolic syndrome need significantly more vitamin E - which could be a serious public health concern, in light of the millions of people who have this condition that's often related to obesity. [More]
Metabolomics and NMR

Metabolomics and NMR

Bruker has been involved in the Phenome Center network since its beginning. Several years ago, the whole visionary concept of a global phenome network was actually born with Professor Jeremy Nicholson and Bruker BioSpin has been part of it since the early stages. [More]
Epigenetic changes drive successful metastases of pancreatic cancer cells

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. [More]
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