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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.
Montefiore-Einstein investigators to present new findings from eight abstracts at IFHNOS 2014

Montefiore-Einstein investigators to present new findings from eight abstracts at IFHNOS 2014

Clinicians and researchers from Montefiore Medical Center and the Albert Einstein College of Medicine of Yeshiva University will present new findings from eight abstracts at the International Federation of Head and Neck Oncologic Societies World Congress being held July 26 - July 30 in New York. [More]
Scientists discover new pathway to manipulate, maintain human ESCs in a "na-ve"

Scientists discover new pathway to manipulate, maintain human ESCs in a "na-ve"

For years, researchers and patients have hoped that embryonic stem cells (ESCs)-capable of forming nearly any cell type in the body-could provide insight into numerous diseases perhaps even be used to treat them. Yet progress has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are "primed" and slightly less plastic than the mouse cells. [More]
People with higher levels of brown fat have better blood sugar control

People with higher levels of brown fat have better blood sugar control

Researchers at the University of Texas Medical Branch at Galveston have shown for the first time that people with higher levels of brown fat, or brown adipose tissue, in their bodies have better blood sugar control, higher insulin sensitivity and a better metabolism for burning fat stores. [More]
Marker identified for population of renal cancer cells with stem-cell-like features

Marker identified for population of renal cancer cells with stem-cell-like features

Researchers have identified a population of clear cell renal cell carcinoma cells positive for the CTR2 marker that possess some stem-cell-like features and are able to induce an angiogenic response in vivo. [More]
Marker identified for population of renal cancer cells with stem-cell-like features

Marker identified for population of renal cancer cells with stem-cell-like features

Researchers have identified a population of clear cell renal cell carcinoma cells positive for the CTR2 marker that possess some stem-cell-like features and are able to induce an angiogenic response in vivo. Targeting CTR2 was shown to decrease drug resistance to cisplatin. [More]
Saudi Arabian researchers detect genetic fragments of MERS-CoV in the air of camel barn

Saudi Arabian researchers detect genetic fragments of MERS-CoV in the air of camel barn

Saudi Arabian researchers have detected genetic fragments of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the air of a barn holding a camel infected with the virus. The work, published this week in mBio-, the online open-access journal of the American Society for Microbiology, indicates that further studies are needed to see if the disease can be transmitted through the air. [More]
Marmoset's unique rapid reproductive system sheds new light on evolution and primate biology

Marmoset's unique rapid reproductive system sheds new light on evolution and primate biology

A team of scientists from around the world led by Baylor College of Medicine and Washington University in St. Louis has completed the genome sequence of the common marmoset - the first sequence of a New World Monkey - providing new information about the marmoset's unique rapid reproductive system, physiology and growth, shedding new light on primate biology and evolution. [More]
Scientists identify genes that may help predict steroid responsiveness in people with EoE

Scientists identify genes that may help predict steroid responsiveness in people with EoE

Results from a clinical trial show that high doses of the corticosteroid fluticasone propionate safely and effectively induce remission in many people with eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus characterized by high levels of white blood cells called eosinophils. [More]
Doctor maps path of discovery for developing potential anticancer agent

Doctor maps path of discovery for developing potential anticancer agent

The journal Cancer Cell today published research led by Dr. Tak Mak mapping the path of discovery to developing a potential anticancer agent. [More]
Starvation can affect health of descendants of famished individuals

Starvation can affect health of descendants of famished individuals

Evidence from human famines and animal studies suggests that starvation can affect the health of descendants of famished individuals. But how such an acquired trait might be transmitted from one generation to the next has not been clear. [More]
Single injection of protein FGF1 enough to restore blood sugar levels

Single injection of protein FGF1 enough to restore blood sugar levels

In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. [More]
CIP2A pathway involved in erlotinib response

CIP2A pathway involved in erlotinib response

Researchers have identified a novel mechanism, involving the cancerous inhibitor of protein phosphatase 2A pathway, which mediates the anti-tumour effects of erlotinib in non-small-cell lung cancer cells without epidermal growth factor receptor mutations. [More]
Findings reveal mechanism underlying hippocampal neuronal injury after TBI

Findings reveal mechanism underlying hippocampal neuronal injury after TBI

Traumatic brain injury (TBI) causes gene expression changes in different brain regions. Cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor expression levels are related to the occurrence and development of TBI. [More]
Advanced Cell Diagnostics’ in situ hybridization technology reaches two major milestones

Advanced Cell Diagnostics’ in situ hybridization technology reaches two major milestones

Advanced Cell Diagnostics Inc. (ACD), a leader in the field of molecular pathology and developer of cell and tissue-based analysis tools, has announced that its RNAscope® RNA in situ hybridization technology has reached two major milestones. In just three years, over 100 peer-reviewed papers featuring the technology have been published, and with the significant increase in use of RNAscope, ACD has now built a library of over 4000 target probes for numerous species. Probes are designed to order in under two weeks, and in just six months the library has grown by over 1500, reflecting the wide interest in ACD’s breakthrough technology. [More]
New potential avenues to predict and prevent ovarian cancer metastasis

New potential avenues to predict and prevent ovarian cancer metastasis

Circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs, scientists at The University of Texas MD Anderson Cancer Center report in Cancer Cell. [More]
Scientists develop RNA that binds cGMP

Scientists develop RNA that binds cGMP

The transmission of signals within cells is dependent on cyclic guanosine monophosphate (cGMP) as an important secondary messenger. German scientists have now developed an RNA that binds cGMP. As reported in the journal Angewandte Chemie, it is possible to suppress the cGMP signal cascade in genetically modified cells that produce this RNA. [More]
Neuroprotective effects of lithium are likely related to gene expressions

Neuroprotective effects of lithium are likely related to gene expressions

Lithium, as a neuroprotective agent, benefits for neuronal survival. Recent cDNA array studies have demonstrated that mood stabilizer lithium exhibits neuroprotective effects through multiple targets. [More]
Transcription factor IRF4 plays key role in brown fat's thermogenic process

Transcription factor IRF4 plays key role in brown fat's thermogenic process

The body contains two types of fat cells, easily distinguished by color: White and brown. While white fat serves to store excess calories until they're needed by the body, brown adipocytes actually burn fat by turning it into heat. [More]
Researchers discover new way by which metabolism is linked to regulation of DNA

Researchers discover new way by which metabolism is linked to regulation of DNA

A research team at the Faculty of Medicine & Dentistry at the University of Alberta have discovered a new way by which metabolism is linked to the regulation of DNA, the basis of our genetic code. The findings may have important implications for the understanding of many common diseases, including cancer. [More]
Highmark, Horizon issued positive coverage policies for Afirma Gene Expression Classifier

Highmark, Horizon issued positive coverage policies for Afirma Gene Expression Classifier

Veracyte, Inc., a molecular diagnostics company pioneering the field of molecular cytology, today announced that two Blue Cross Blue Shield–affiliated organizations, Highmark Inc. and Horizon Blue Cross Blue Shield of New Jersey, have issued positive coverage policies for the company's Afirma Gene Expression Classifier (GEC). [More]