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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study sheds light on how extra chromosome 21 upsets equilibrium of entire genome in Down syndrome

Occurring in about one per eight hundred births, Down syndrome - or trisomy 21 - is the most frequent genetic cause of intellectual disability. It results from a chromosomal abnormality where cells of affected individuals contain a third copy of chromosome 21 (1% of the human genome). [More]

Engineering cell-based, biological devices may selectively kill cancer cells without disrupting healthy cells

​A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other sites of disease. [More]
New mouse study indicates that mutant protein in muscle cells is responsible for SBMA

New mouse study indicates that mutant protein in muscle cells is responsible for SBMA

Sometimes known as Kennedy's disease, spinal and bulbar muscular atrophy (SBMA) is a rare inherited neuromuscular disorder characterized by slowly progressive muscle weakness and atrophy. [More]
New data focuses on different approaches to improve diagnosis and treatment of HCC

New data focuses on different approaches to improve diagnosis and treatment of HCC

Epidemiological, genetic and clinical data presented today at the International Liver CongressTM 2014 are collectively focussed on different approaches designed to improve the diagnosis, staging and treatment of hepatocellular carcinoma (HCC). [More]
Researchers investigate role of microRNAs in breast cancer cells

Researchers investigate role of microRNAs in breast cancer cells

Metastasis — the spreading of cancer cells from a primary tumor site to other parts of the body — generally leads to poorer outcomes for patients, so oncologists and researchers are constantly seeking new ways to detect and thwart this malicious process. [More]
miRNA expression and inhibition: an interview with Maja Petkovic, AMSBIO

miRNA expression and inhibition: an interview with Maja Petkovic, AMSBIO

RNA interference is a process in which RNA molecules inhibit gene expression. This gene silencing process is controlled by RNA-induced silencing complex or RISC and is initiated by small duplex RNA molecules or miRNA that is present inside cell plasma. [More]
Researchers develop novel assay to identify genes controlling pharynx regeneration in flatworms

Researchers develop novel assay to identify genes controlling pharynx regeneration in flatworms

As multicellular creatures go, planaria worms are hardly glamorous. To say they appear rudimentary is more like it. These tiny aquatic flatworms that troll ponds and standing water resemble brown tubes equipped with just the basics: a pair of beady light-sensing "eyespots" on their head and a feeding tube called the pharynx (which doubles as the excretory tract) that protrudes from a belly sac to suck up food. [More]
Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. [More]
Concise analysis of cancer drug delivery markets

Concise analysis of cancer drug delivery markets

Research and Markets (http://www.researchandmarkets.com/research/qxfqmk/drug_delivery_in) has announced the addition of a new report "Drug Delivery in Cancer - Technologies, Markets and Companies" to their offering. [More]
Vibrational spectroscopy opens up new ways to diagnose chronic diseases

Vibrational spectroscopy opens up new ways to diagnose chronic diseases

In today’s ageing population, resulting in a rising prevalence of chronic diseases such as neurodegeneration, the need for simple, non-invasive methods to diagnose or screen for important medical conditions becomes more and more relevant. Objective and cost-effective approaches capable of diagnosing early-stage disease in point-of-care clinical settings are necessary to facilitate the personalising of therapies to prevent or slow down pathology development. [More]
Multiple genomic data could help improve studies of association between genes and disease

Multiple genomic data could help improve studies of association between genes and disease

The difference between merely throwing around buzzwords like "personalized medicine" and "big data" and delivering on their medical promise is in the details of developing methods for analyzing and interpreting genomic data. In a pair of new papers, Brown University epidemiologist Yen-Tsung Huang and colleagues show how integrating different kinds of genomic data could improve studies of the association between genes and disease. [More]
Natural compound from green tomatoes protects against muscle atrophy

Natural compound from green tomatoes protects against muscle atrophy

Using a screening method that previously identified a compound in apple peel as a muscle-boosting agent, a team of University of Iowa scientists has now discovered that tomatidine, a compound from green tomatoes, is even more potent for building muscle and protecting against muscle atrophy. [More]

bioTheranostics, Prime Health Services sign contract to expand genomic tests

bioTheranostics, Inc., the leading genomic solutions provider for cancer diagnosis, has signed a contract with Prime Health Services, Inc., a national preferred provider organization network, to cover the company's genomic tests for breast cancer patients and patients with metastatic disease. [More]
Abnormal levels of lipid molecules can trigger autism during prenatal brain development

Abnormal levels of lipid molecules can trigger autism during prenatal brain development

In a groundbreaking York University study, researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. [More]

Nanostring Technologies launches nCounter PanCancer Pathways Panel

NanoString Technologies, Inc., (NASDAQ:NSTG) a provider of life science tools for translational research and molecular diagnostic products, today announced the launch of the nCounter® PanCancer Pathways Panel, a highly-multiplexed, digital gene expression assay that offers a unique way for translational researchers to investigate cancer biology across all major cancer pathways. [More]

Combination therapy with MEK and BRAF inhibitors for anaplastic thyroid cancer proves effective

Researchers from the Jacks Laboratory at MIT's Koch Institute for Integrative Cancer Research (KI) have developed and characterized a genetically engineered mouse that successfully models progression from papillary thyroid cancer, which has an excellent prognosis, to anaplastic thyroid cancer (ATC), a highly lethal disease. [More]
TSRI reveals new aspects of more potent anti-diabetic drugs with fewer serious side effects

TSRI reveals new aspects of more potent anti-diabetic drugs with fewer serious side effects

Scientists thought they basically knew how the most common drugs used to treat type 2 diabetes worked, but a new study from the Florida campus of The Scripps Research Institute (TSRI) reveals unexpected new aspects of the process. [More]
Study examines links between parental obesity and risk of autism developmental in child

Study examines links between parental obesity and risk of autism developmental in child

Several studies have looked at possible links between maternal obesity during pregnancy and the risk of developmental disorders in the child. However, paternal obesity could be a greater risk factor than maternal obesity, according to a new study from the Norwegian Institute of Public Health. [More]

Findings could lead to more potent anti-diabetic drugs with fewer side effects

Scientists thought they basically knew how the most common drugs used to treat type 2 diabetes worked, but a new study from the Florida campus of The Scripps Research Institute (TSRI) reveals unexpected new aspects of the process. These findings could eventually lead to more potent anti-diabetic drugs with fewer serious side effects. [More]
Research suggests NEDD9 scaffolding protein activates oncogenic signaling pathways in cancer cells, encourages metastases

Research suggests NEDD9 scaffolding protein activates oncogenic signaling pathways in cancer cells, encourages metastases

Researchers from Fox Chase Cancer Center have shown that NEDD9, a scaffolding protein responsible for regulating signaling pathways in the cell, promotes the growth and spread of epithelial ovarian cancer. [More]