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Genetic screening and counseling likely to benefit childhood cancer survivors, study suggests

Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented today at the annual meeting of the American Association for Cancer Research.

4 Apr 2017

Attacking TERT protein may be effective approach to destroying ALM cancer cells

A team of researchers report a significant genetic association linked to an aggressive form of melanoma in a study published today in the journal Genome Research.

4 Apr 2017

Scientists develop novel technique to screen non-coding DNA of genome for diseases

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation.

4 Apr 2017

Extreme short and long telomeres linked to increased cancer risk

The length of the telomere "caps" of DNA that protect the tips of chromosomes may predict cancer risk and be a potential target for future therapeutics, University of Pittsburgh Cancer Institute scientists will report today at the AACR Annual Meeting in Washington, D.C.

3 Apr 2017

Researchers develop new technologies to measure key proteins that serve as markers for tumors

Dr. Amanda Paulovich, whose lab has a leading role in the Beau Biden Cancer Moonshot, will speak April 5 at the American Association for Cancer Research annual meeting about her lab's pioneering methods to measure proteins that serve as tumor markers.

3 Apr 2017

Pioneering IVF technique offers hope to families with inheritable mitochondrial disorders

Details of a pioneering IVF technique using mitochondrial replacement therapy (MRT) have been revealed, giving hope to those families with inheritable mitochondrial disorders that they may be able to have healthy children in the future.

3 Apr 2017

Study shows how early-life BPA exposure leads to NAFLD in adulthood

Exposure during infancy to the common plasticizer bisphenol A "hijacks" and reprograms genes in the liver of newborn rats, leading to nonalcoholic fatty liver disease in adulthood.

2 Apr 2017

Experts report serious limitations to technology for screening embryos

The healthy development of an embryo created through in vitro fertilization (IVF) depends on whether most, if not all, of the cells have the proper number of chromosomes.

31 Mar 2017

Study provides new understanding of molecular mechanisms of HPV-induced tumors

The incidence of human papillomavirus (HPV)-associated (HPV+) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and is now more frequently diagnosed than uterine cervical cancer in the United States.

31 Mar 2017

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

National Human Genome Research Institute researchers have identified new genes associated with the Erdheim-Chester disease and some possible new therapies. Findings on this ultra-rare disease, found in approximately 600 people in the world, were published in Blood Advances.

31 Mar 2017

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Corneal diseases are among the most common causes of visual impairment and blindness, with Fuchs endothelial corneal dystrophy (FECD), a gradual swelling and clouding of the cornea, being the most common reason for eventual corneal transplants.

31 Mar 2017

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms.

30 Mar 2017

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body.

30 Mar 2017

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

By engineering an on/off switch into a weakened form of HIV, University of Nebraska-Lincoln researchers have enhanced the safety and effectiveness of a potential vaccine for the virus that has killed approximately 35 million people during the past 35 years.

30 Mar 2017

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo

30 Mar 2017

Study identifies specific genetic risk factors that increase susceptibility to gliomas

A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults

29 Mar 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

TSRI researchers reveal how viruses incapacitate bacterial defense system

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas.

28 Mar 2017

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Jackson Laboratory Professor Yijun Ruan, Ph.D., a leader in the study of the three-dimensional organization of the human genome, has received a three-year grant totaling $1,050,000 from the international Human Frontier Science Program to explore the fundamental mechanics involved in memory and learning as well as epilepsy.

28 Mar 2017

Rogue proteins involved in breast cancer point to potential treatment options

For patients with difficult-to-treat cancers, doctors increasingly rely on genomic testing of tumors to identify errors in the DNA that indicate a tumor can be targeted by existing therapies.

28 Mar 2017

Genome News and Research

Genetic screening and counseling likely to benefit childhood cancer survivors, study suggests

Attacking TERT protein may be effective approach to destroying ALM cancer cells

Scientists develop novel technique to screen non-coding DNA of genome for diseases

Extreme short and long telomeres linked to increased cancer risk

Researchers develop new technologies to measure key proteins that serve as markers for tumors

Pioneering IVF technique offers hope to families with inheritable mitochondrial disorders

Study shows how early-life BPA exposure leads to NAFLD in adulthood

Experts report serious limitations to technology for screening embryos

Study provides new understanding of molecular mechanisms of HPV-induced tumors

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

Researchers uncover novel genetic links underlying Fuchs endothelial corneal dystrophy

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

Researchers shed light on genome reorganization after fertilization in single-cell mammalian embryo

Study identifies specific genetic risk factors that increase susceptibility to gliomas

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

TSRI researchers reveal how viruses incapacitate bacterial defense system

JAX professor receives HFSP grant for 3D genome studies of memory, learning and epilepsy

Rogue proteins involved in breast cancer point to potential treatment options

Genetics & Genomics - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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