Glycolysis News and Research

RSS

Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation of both aerobic and anaerobic cellular respiration. It takes place in the cytosol of a cell and is the foundation of both aerobic and anaerobic cellular respiration.

Study identifies important regulator of neuron function and survival

Scientists studying neuronal energy metabolism found evidence that the loss of an important energy regulator called AMPK in neural stem cells or glial cells called astrocytes causes neuronal death in laboratory rodents.

1 Sep 2020

Scientists identify new treatment targets for blinding retinal disease

When the eye isn't getting enough oxygen in the face of common conditions like premature birth or diabetes, it sets in motion a state of frenzied energy production that can ultimately result in blindness, and now scientists have identified new points where they may be able to calm the frenzy and instead enable recovery

10 Aug 2020

Modulating immunometabolic processes to control lung infection

When drugs to kill microbes are ineffective, host-directed therapy uses the body's own immune system to deal with the infection.

23 Jul 2020

Blood cell damage in COVID-19 may compromise oxygen transport

Researchers in the U.S. have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may alter key protein structures on red blood cells and compromise the transport and delivery of oxygen in patients with coronavirus disease 2019 (COVID-19).

1 Jul 2020

USC researchers unlock fatal vulnerability in many cancer cells

Like any cells in the body, cancer cells need sugar - namely glucose - to fuel cell proliferation and growth.

17 Jun 2020

Study reveals how a fat cell's immune response worsens obesity

When obesity occurs, a person's own fat cells can set off a complex inflammatory chain reaction that can further disrupt metabolism and weaken immune response--potentially placing people at higher risk of poor outcomes from a variety of diseases and infections, including COVID-19.

2 Jun 2020

Scientists discover how the iron chelator drives immune system to deal with TB

Although COVID-19 commands the headlines today, tuberculosis (TB) remains the biggest infection killer in the world and multiple drug resistant TB, which does not respond to regular antibiotics, continues to be a major threat to global health.

13 May 2020

New discovery could lead to better strategies for preventing breast cancer metastasis

New discovery in breast cancer could lead to better strategies for preventing the spread of cancer cells to other organs in the body, effectively reducing mortality in breast cancer patients.

8 Mar 2020

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

A new culprit -- hydrogen sulfide -- has been found for the deadly infectious disease tuberculosis. Hydrogen sulfide gas is known for its rotten egg smell, yet it has normal physiological roles in the human body to communicate among cells.

3 Mar 2020

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Patients with autoimmune diseases like multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis have an imbalance between two types of immune system T cells.

26 Feb 2020

Stem cell discovery could open the door to new approach for bone marrow transplantation

Mount Sinai researchers have discovered a way to enhance the potency of blood-forming stem cells, potentially opening the door to a new approach for bone marrow transplantation, according to a study being published on February 27 in Cell Stem Cell.

26 Feb 2020

Researchers uncover how cancer cells override environmental cues to consume energy

Using human lung cancer cells, UT Southwestern researchers have uncovered how cells in general modulate their energy consumption based on their surroundings and, furthermore, how cancer cells override those cues to maximize energy use.

24 Feb 2020

KAIST researchers identify mechanism that fuels a 'domino effect' in cancer drug resistance

KAIST researchers have identified mechanisms that relay prior acquired resistance to the first-line chemotherapy to the second-line targeted therapy, fueling a "domino effect" in cancer drug resistance.

11 Feb 2020

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Researchers from the group of Jeroen Bakkers at the Hubrecht Institute have found that the muscle cells in the heart of zebrafish change their metabolism, the way in which they generate energy, during heart regeneration.

5 Feb 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

NIH-funded research finds differences in energy use by immune T cells in ME/CFS

New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy.

12 Dec 2019

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Researchers have shown that painful endometriosis symptoms could be alleviated using an investigational cancer drug.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Article reveals new mechanism of programmed aging

Nature has sentenced humans to an inevitable death from the time of birth; the natural instrument of execution is the aging process. According to modern scientific notions, only two root causes of aging can be: stochastic physiological damage or the implementation of a special genetic program in the body.

25 Nov 2019

UChicago researchers reveal the secret of cancer-related Warburg effect

A new study, led by researchers at the University of Chicago, provides an answer to why cancer cells consume and use nutrients differently than their healthy counterparts and how that difference contributes to their survival and growth.

23 Oct 2019