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New experimental model may predict eventual cardiac phenotype in pediatric patients

New experimental model may predict eventual cardiac phenotype in pediatric patients

An experimental model uses genetics-guided biomechanics and patient-derived stem cells to predict what type of inherited heart defect a child will develop, according to authors of a new study in the journal Cell. [More]
Arterial switch to 12 o'clock position linked to myocardial ischaemia risk in adolescence

Arterial switch to 12 o'clock position linked to myocardial ischaemia risk in adolescence

Arterial switch to the 12 o'clock position is associated with abnormal coronary perfusion in adolescence, reveals research presented today at EuroCMR 2016.1 Babies born with transposition of the great arteries (TGA) undergo the arterial switch operation in the first days of life. [More]
Boston Children's, Edwards Lifesciences launch new prosthetic heart valve study for congenital heart defect

Boston Children's, Edwards Lifesciences launch new prosthetic heart valve study for congenital heart defect

Surgeons in the Heart Center at Boston Children's Hospital have partnered with Edwards Lifesciences to launch a clinical study of a new prosthetic heart valve for patients born with a congenital heart defect. [More]
New analysis of heart structure, function for prevention of cardiac emergencies in basketball players

New analysis of heart structure, function for prevention of cardiac emergencies in basketball players

An analysis of the cardiac structure and function of more than 500 National Basketball Association (NBA) players provides information that can be incorporated into clinical assessments for the prevention of cardiac emergencies in basketball players and the athletic community at large, according to a study published online by JAMA Cardiology. [More]
Long-term survival of 'blue babies' and patients with congenital heart defects reasonably good

Long-term survival of 'blue babies' and patients with congenital heart defects reasonably good

Over 90 percent of those operated on for congenital heart defects as children, for example, due to blue baby syndrome, are alive 20 years post-surgery. A new doctoral thesis at Sahlgrenska Academy has explored this issue. [More]
New methodology could spare kids from unnecessary heart surgery

New methodology could spare kids from unnecessary heart surgery

What better way to celebrate Valentine's Day than help save a child's heart? That's what Vittoria Flamini, an industry assistant professor in Tandon's Department of Mechanical and Aerospace Engineering, has in mind. [More]
TBX5 gene expression could play key role in congenital heart disease

TBX5 gene expression could play key role in congenital heart disease

Congenital heart disease is the most common birth defect and the leading cause of all infant deaths in the United States. Mutations in the gene TBX5 have been shown to cause both rare and more prevalent forms of congenital heart disease, yet the underlying mechanisms have remained unclear. [More]
Researchers demonstrate new way to reduce preterm birth using nanoparticles

Researchers demonstrate new way to reduce preterm birth using nanoparticles

Using nanoparticles to engineer a special drug, a team of researchers has demonstrated in mice a new way to both reduce preterm birth and avoid the risks of medication in pregnancy to unborn babies. [More]

Cornell researchers discover natural triggers that may reduce congenital heart defects among newborns

Cornell biomedical engineers have discovered natural triggers that could reduce the chance of life-threatening, congenital heart defects among newborn infants. Those triggers can override developmental, biological miscues, leading to proper embryonic heart and valve formation. [More]
Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Some of the same gene mutations that cause heart defects in children also lead to neurodevelopmental delays, including learning disabilities. A large study of congenital heart disease (CHD) reveals overlapping genetic influences during early childhood development. [More]
IQWiG finds certain benefit for pulse oximetry screening in newborns with congenital heart defects

IQWiG finds certain benefit for pulse oximetry screening in newborns with congenital heart defects

There is a hint of a benefit of pulse oximetry screening as an add-on test to existing standard examinations for detection of critical congenital heart defects in newborns: More cases are detected by additional screening than by the two clinical examinations U1 and U2 alone. This means that newborns can be treated at an early stage and may be protected from severe late complications. [More]
Preeclampsia during pregnancy linked to heart defects in infants

Preeclampsia during pregnancy linked to heart defects in infants

Pregnant women with preeclampsia have a higher risk of delivering an infant with a congenital heart defect. An extensive study of 1.9 million mother and infant pairs by a team at the University of Montreal Hospital Research Centre has shown significant association between these diseases in mothers and newborns from early pregnancy. [More]
Pregnant women with elevated blood-sugar levels more likely to have babies with heart defects

Pregnant women with elevated blood-sugar levels more likely to have babies with heart defects

Pregnant women with elevated blood-sugar levels are more likely to have babies with congenital heart defects, even if their blood sugar is below the cutoff for diabetes, according to a new study from the Stanford University School of Medicine and Stanford Children's Health. [More]
Researchers design specialized catheter for fixing holes in the heart

Researchers design specialized catheter for fixing holes in the heart

Researchers from Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences and the Karp Lab at Brigham and Women's Hospital have jointly designed a specialized catheter for fixing holes in the heart using a biodegradable adhesive and patch. [More]
Children's Hospital Los Angeles successfully implants Melody Transcatheter Pulmonary Valve in child actor

Children's Hospital Los Angeles successfully implants Melody Transcatheter Pulmonary Valve in child actor

Cardiologists from Children's Hospital Los Angeles successfully implanted a Melody Transcatheter Pulmonary Valve in child actor Max Page, the boy who made headlines playing mini Darth Vader in a 2011 Super Bowl ad for Volkswagen. [More]
Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Children born with the major congenital heart defect hypoplastic left heart syndrome (HLHS) often must undergo a series of corrective surgeries beginning at birth. While most have the standard three-stage Norwood procedure, a hybrid strategy has been introduced to offset some disadvantages associated with the Norwood surgeries. In a report in The Journal of Thoracic and Cardiovascular Surgery, investigators compare whether outcomes can be improved if an arterial shunt is used as a source of pulmonary blood flow rather than the more conventional venous shunt as part of the hybrid strategy of HLHS surgical reconstruction. [More]
Certain metabolites in the blood could predict clinical outcome in children undergoing heart surgery

Certain metabolites in the blood could predict clinical outcome in children undergoing heart surgery

The study, published today in the journal Critical Care Medicine and carried out at Royal Brompton Hospital, followed children undergoing surgery for congenital heart disease, and found that by analysing metabolites in the blood -- molecules created as a result of metabolism -- it was possible to predict a child's clinical outcome. [More]
Older mothers who exercise during pregnancy can reduce baby's risk of congenital heart defects

Older mothers who exercise during pregnancy can reduce baby's risk of congenital heart defects

In people, a baby's risk of congenital heart defects is associated with the age of the mother. Risk goes up with increasing age. Newborn mice predisposed to heart defects because of genetic mutations show the same age association. [More]
New app directly connects single ventricle heart defect patients to doctors

New app directly connects single ventricle heart defect patients to doctors

A powerful new app is directly connecting single ventricle heart defect patients to their doctors, dramatically improving their monitoring while they recover from heart surgery at home. Girish Shirali, MBBS, FACC, FASE, Co-Director of the Ward Family Heart Center at Children's Mercy Kansas City, will report today on how the technology is changing patient care at the American Heart Association Scientific Sessions 2014. [More]
High risk for congenital heart defects in Down syndrome provides tool to identify changes in genes

High risk for congenital heart defects in Down syndrome provides tool to identify changes in genes

Down syndrome is the most common chromosomal abnormality in humans, involving a third copy of all or part of chromosome 21. In addition to intellectual disability, individuals with Down syndrome have a high risk of congenital heart defects. However, not all people with Down syndrome have them – about half have structurally normal hearts. [More]
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