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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.
Researchers reconstruct 3D images of protein structures that link heart muscle cells in working groups

Researchers reconstruct 3D images of protein structures that link heart muscle cells in working groups

Diseased hearts may be thrown out of rhythm by structural differences -- now visible for the first time -- in protein groups that connect heart muscle cells, according to the authors of a study to be published in the journal Nature Communications online Jan. 20. [More]
New blood biomarkers could lead to better evaluation of treatment for patients with PAH

New blood biomarkers could lead to better evaluation of treatment for patients with PAH

New blood biomarkers reflecting vasoreactivity in lung blood vessels of patients with heart- and lung disease, can lead to simplified diagnostics and better evaluation of treatment for patients with the condition pulmonary arterial hypertension (PAH). [More]
Specialized oral nutrition supplement associated with 50% lower death rate in older patients

Specialized oral nutrition supplement associated with 50% lower death rate in older patients

Results from a new clinical trial show that a specialized oral nutrition supplement was associated with a 50 percent lower death rate in older malnourished patients with a heart or lung disease 90 days following hospitalization. [More]
Findings offer potential new therapeutic target to boost strength of heart muscle contractions

Findings offer potential new therapeutic target to boost strength of heart muscle contractions

Researchers at UT Southwestern Medical Center have identified a previously unrecognized small protein in cells of the human heart that plays a key role in heart muscle contraction. The protein is made from an RNA that was previously believed to be a blank or non-coding RNA, suggesting there may be many other small 'non-coding' segments that play important biological roles. [More]
Alignment Healthcare, HCA West Florida partner to better serve Medicare beneficiaries in West Florida

Alignment Healthcare, HCA West Florida partner to better serve Medicare beneficiaries in West Florida

Alignment Healthcare, a company focused on improving the health of the Medicare population, announced that it has joined forces with HCA West Florida to better serve Medicare beneficiaries in three West Florida counties: Manatee, Pinellas and Sarasota. [More]
Novel therapy may help in diagnosing, treating heart disease in humans

Novel therapy may help in diagnosing, treating heart disease in humans

A novel therapy tested by University of Guelph scientists for treating a fatal heart disorder in dogs might ultimately help in diagnosing and treating heart disease in humans. [More]
UCSD Skaggs School of Pharmacy, Janssen R&D partner to identify new therapeutic targets for Chagas disease

UCSD Skaggs School of Pharmacy, Janssen R&D partner to identify new therapeutic targets for Chagas disease

Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego have entered into a research collaboration with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to identify new therapeutic targets for Chagas disease, a parasitic infection that is the leading cause of heart failure in Latin America. [More]
ImpediMed introduces L-Dex system for clinical assessment of lymphedema in U.S.

ImpediMed introduces L-Dex system for clinical assessment of lymphedema in U.S.

ImpediMed Limited, a global provider of medical technology to measure, monitor and manage fluid status in patients, has announced the U.S. commercial launch of its L-Dex system to aid in the clinical assessment of lymphedema. [More]
ISHLT issues new list of criteria to determine patient eligibility for heart transplant

ISHLT issues new list of criteria to determine patient eligibility for heart transplant

To determine patient eligibility for heart transplant, the International Society for Heart Lung Transplantation maintains a list of criteria, first issued in 2006, that acts as a guideline for physicians. [More]
Penn study provides new insight into cause of peripartum cardiomyopathy in pregnant women

Penn study provides new insight into cause of peripartum cardiomyopathy in pregnant women

Each year approximately 1 in 1,000 pregnant women will experience peripartum cardiomyopathy, an uncommon form of often severe heart failure that occurs in the final month of pregnancy or up to five months following delivery. But the cause of peripartum cardiomyopathy has been largely unknown - until now. [More]
Scientists find genetic link to unexplained heart failure affecting pregnant women

Scientists find genetic link to unexplained heart failure affecting pregnant women

Scientists have found that women who suffer unexplained heart failure towards the end of pregnancy or shortly after giving birth share certain genetic changes. [More]
Diet or aerobic exercise improves ability to exercise for obese older patients with heart failure

Diet or aerobic exercise improves ability to exercise for obese older patients with heart failure

Among obese older patients with a common type of heart failure, calorie restriction or aerobic exercise training improved their ability to exercise without experiencing shortness of breath, although neither intervention had a significant effect on a measure of quality of life, according to a study in the January 5 issue of JAMA. [More]
FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Ionis Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation to IONIS-HTTRx for the treatment of patients with Huntington's disease (HD). [More]
Ardelyx announces positive results from RDX022 clinical study for treatment of hyperkalemia

Ardelyx announces positive results from RDX022 clinical study for treatment of hyperkalemia

Ardelyx, Inc., a clinical-stage biopharmaceutical company focused on gastrointestinal and cardio-renal diseases, today announced positive results of an open label clinical study evaluating the pharmacodynamic (PD) activity of RDX022 in healthy adult volunteers. [More]
Millions of older adults make infectious disease-related emergency department visits each year

Millions of older adults make infectious disease-related emergency department visits each year

Investigators estimate that during 2012, there were more than 3.1 million emergency department visits for infectious diseases among elderly US adults. [More]
True Wearables launches world's first wireless, fully disposable, single-use pulse oximeter

True Wearables launches world's first wireless, fully disposable, single-use pulse oximeter

True Wearables, Inc., a medical device start-up based in Orange County, CA, announced today Oxxiom, the world's first wireless, continuous, fully disposable, single-use pulse oximeter. Oxxiom measures arterial oxygen saturation (SpO2), pulse rate (PR), and perfusion index (PI). [More]
Researchers successfully use CRISPR to treat adult mouse model of Duchenne muscular dystrophy

Researchers successfully use CRISPR to treat adult mouse model of Duchenne muscular dystrophy

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy. This marks the first time that CRISPR has successfully treated a genetic disease inside a fully developed living mammal with a strategy that has the potential to be translated to human therapy. [More]
Pacemaker Induced Transient Asynchrony could help slow down progression of heart failure

Pacemaker Induced Transient Asynchrony could help slow down progression of heart failure

Johns Hopkins has demonstrated in animals that applying a pacemaker's mild electrical shocks to push the heart in and out of normal synchronized contraction for part of each day may be an effective way to slow down the progression of heart failure, a disorder that afflicts millions of Americans. [More]
Selexipag holds promise for treatment of pulmonary hypertension

Selexipag holds promise for treatment of pulmonary hypertension

Living with pulmonary arterial hypertension is challenging, but the chore of treating the rare heart disease may change following promising clinical trial data to be published in the Dec. 24 issue of the New England Journal of Medicine. [More]
Researchers identify underlying molecular mechanism of cardiac hypertrophy

Researchers identify underlying molecular mechanism of cardiac hypertrophy

Specific genes are responsible for determining cell growth and differentiation during the early stages of cardiac development. Reactivation of these genes later in life can lead to an abnormal thickening of the heart muscle. Researchers from Charité -- Universitätsmedizin Berlin lead by Professor Silke Rickert-Sperling have been able to identify the underlying molecular mechanism. [More]
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