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A hormone is a chemical released by one or more cells that affects cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. It is essentially a chemical messenger that transports a signal from one cell to another.
Researchers refine breast cancer risk model to give more accurate assessment

Researchers refine breast cancer risk model to give more accurate assessment

A national risk model that gauges a woman's chance of developing breast cancer has been refined to give a more accurate assessment. The revised figures, based on data from more than one million patients, reveal a 300 percent increase in a subset of women whose five-year risk is estimated at 3 percent or higher. [More]
Palatin applauds FDA's approval of flibanserin for women living with hypoactive sexual desire disorder

Palatin applauds FDA's approval of flibanserin for women living with hypoactive sexual desire disorder

Palatin Technologies, Inc. is a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical needs and commercial potential. Palatin's lead product under development is bremelanotide for the treatment of female sexual dysfunction (FSD). [More]
NIH funds multicenter study to evaluate impact of medical treatment in transgender youth

NIH funds multicenter study to evaluate impact of medical treatment in transgender youth

The National Institutes of Health has awarded $5.7M for a five-year, multicenter study, which will be the first in the U.S. to evaluate the long-term outcomes of medical treatment for transgender youth. [More]
FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly. [More]
Researchers examine potential effects of sex development disorders in children, adolescents

Researchers examine potential effects of sex development disorders in children, adolescents

While it may not shock you to learn that children born with disorders of sex development (DSD) face challenges, Concordia University researchers have confirmed that these go far beyond the physical. [More]
Low-fat diets better than low-carb diets for weight loss, NIH study finds

Low-fat diets better than low-carb diets for weight loss, NIH study finds

In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets. Carb restriction lowered production of the fat-regulating hormone insulin and increased fat burning as expected, whereas fat restriction had no observed changes in insulin production or fat burning. [More]
Improved method for building proteins into antibodies

Improved method for building proteins into antibodies

Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now a team led by scientists at The Scripps Research Institute (TSRI) has devised an improved method for accomplishing this protein-engineering feat. [More]
TSRI-led team devises selection-based, protein-engineering method to work on obesity therapy

TSRI-led team devises selection-based, protein-engineering method to work on obesity therapy

Some proteins exist so fleetingly in the bloodstream that they can’t be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now a team led by scientists at The Scripps Research Institute has devised an improved method for accomplishing this protein-engineering feat. [More]
Neurocrine completes enrollment in Phase III clinical trial of NBI-98854 in tardive dyskinesia patients

Neurocrine completes enrollment in Phase III clinical trial of NBI-98854 in tardive dyskinesia patients

Neurocrine Biosciences, Inc. announced today that it has recently completed subject randomization of the Phase III clinical trial (Kinect 3 Study) of its proprietary Vesicular Mono-Amine Transporter 2 (VMAT2) compound NBI-98854 in tardive dyskinesia patients. [More]
Chances of survival due to chemotherapy significantly lower for older breast cancer patients

Chances of survival due to chemotherapy significantly lower for older breast cancer patients

Chemotherapy prolongs life for older adults with most types of cancer, but for women over the age of 80 with breast cancer, the chances of survival due to chemotherapy are significantly lower, according to a study led by researchers from The University of Texas Health Science Center at Houston. [More]
New research could help develop precision medicine for primary aldosteronism

New research could help develop precision medicine for primary aldosteronism

Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high. [More]
Study determines structure of plant hormone that helps regulate plants’ responses to insects, microorganisms

Study determines structure of plant hormone that helps regulate plants’ responses to insects, microorganisms

An international collaboration including scientists from the Florida campus of The Scripps Research Institute has determined the structure of a plant hormone that plays a crucial role in regulating plants’ responses to insects and disease-causing microorganisms as well as normal growth and development. [More]
Postmenopausal women more likely to use vaginal estrogen to achieve significantly higher sexual quality of life

Postmenopausal women more likely to use vaginal estrogen to achieve significantly higher sexual quality of life

Local vaginal estrogen (VE) appears to have escaped the shroud of doubt cast upon hormone therapy as a result of the Women's Health Initiative Study by providing numerous medical benefits without systemic effects. That's according to a new study reported online today in Menopause, the journal of The North American Menopause Society. [More]
Retrieving eggs at earlier stage of fertility treatment may improve pregnancy rates for older women

Retrieving eggs at earlier stage of fertility treatment may improve pregnancy rates for older women

IVF success rates for women aged 43 and above could improve by retrieving eggs from their ovaries at an earlier stage of fertility treatment, according to a new study published today in the Journal of Endocrinology. [More]
TEAAM trial finds that testosterone has no effect on atherosclerosis progression

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Testosterone sales have grown rapidly over the last decade, but few studies have examined the long-term effects of taking testosterone on cardiovascular health and other important outcomes. This week, investigators from Brigham and Women's Hospital report the results of the Testosterone's Effects on Atherosclerosis Progression in Aging Men (TEAAM) trial in the Journal of the American Medical Association. [More]
Education intervention can improve physicians’ understanding of transgender issues

Education intervention can improve physicians’ understanding of transgender issues

The term "transgender" has made its way into mainstream media thanks to Caitlyn Jenner, previously known as Bruce Jenner, who came out as a transgender woman earlier this year. [More]
Clinical study shows two-drug combination can prolong survival in men with metastatic prostate cancer

Clinical study shows two-drug combination can prolong survival in men with metastatic prostate cancer

Newly diagnosed patients with metastatic, hormone-sensitive prostate cancer gained a dramatic survival benefit when started on two drugs simultaneously, rather than delaying the second drug until the cancer began to worsen, according to results of a clinical trial led by a Dana-Farber Cancer Institute scientist. [More]
Swedish study reveals combined effects of smoking and early menopause on overall mortality

Swedish study reveals combined effects of smoking and early menopause on overall mortality

Women may now have yet another reason to quit smoking given the results of a new study that is being reported online today in Menopause, the journal of The North American Menopause Society. The Swedish study involving 25,474 women is the first to quantify the combined effects of smoking and age at menopause on overall mortality in terms of survival time by investigating the role of smoking as a possible effect modifier. [More]
Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Since the classical studies of Jacob and Monod in the early 1960s, it has been evident that genome sequences contain not only blueprints for genes and the proteins that they encode, but also the instructions for a coordinated regulatory program that governs when, where and to what extent these genes and proteins are expressed. [More]
Atomic level images reveal how neuropeptide hormone neurotensin may activate its receptors

Atomic level images reveal how neuropeptide hormone neurotensin may activate its receptors

Many hormones and neurotransmitters work by binding to receptors on a cell's exterior surface. This activates receptors causing them to twist, turn and spark chemical reactions inside cells. [More]
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