Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferers

Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferers

Researchers discover how tau disrupts functioning of nerve cells even before forming tangles

Researchers discover how tau disrupts functioning of nerve cells even before forming tangles

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier

Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Easing cellular traffic jams in Huntington’s disease may save brain cells

Easing cellular traffic jams in Huntington’s disease may save brain cells

New study finds link between neural tube defects in infants and neurodegenerative diseases

New study finds link between neural tube defects in infants and neurodegenerative diseases

EPFL scientists develop synthetic methods to crack code of Huntington's disease

EPFL scientists develop synthetic methods to crack code of Huntington's disease

UCLA study traces Pavlovian response to small cluster of brain cells

UCLA study traces Pavlovian response to small cluster of brain cells

Stem cells strictly abide by innate developmental clocks, study shows

Stem cells strictly abide by innate developmental clocks, study shows

Study finding suggests new ways in which genetic mutations may cause brain disorders

Study finding suggests new ways in which genetic mutations may cause brain disorders

Discovery of early biomarkers paves way for new insight into Huntington's disease

Discovery of early biomarkers paves way for new insight into Huntington's disease

SBP scientists identify autophagy linked to beneficial effects of enduring temporary stress

SBP scientists identify autophagy linked to beneficial effects of enduring temporary stress

Duke Health researchers identify potential new drug target for Huntington's disease

Duke Health researchers identify potential new drug target for Huntington's disease

Defective brain cells disposing toxic proteins may be linked to neurodegenerative diseases

Defective brain cells disposing toxic proteins may be linked to neurodegenerative diseases

Designer compound may be effective tool for tackling tau-related disorders

Designer compound may be effective tool for tackling tau-related disorders

Both accelerator and brake in the brain control all types of movements, research shows

Both accelerator and brake in the brain control all types of movements, research shows

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Survey reports symptoms and treatments that impact lives of HD patients and caregivers

Survey reports symptoms and treatments that impact lives of HD patients and caregivers