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Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI, and other institutions have discovered that the activating hotspot L205R mutation in PRKACA gene was closely associated with adrenocortical tumors (ACTs), and the relationship of recurrently mutated DOT1L and CLASP2 with ACTs' other subtypes. [More]
Astellas, Medivation submit European Marketing Authorization Application for XTANDI capsules

Astellas, Medivation submit European Marketing Authorization Application for XTANDI capsules

Astellas Pharma Inc. and Medivation Inc. today announced the submission of a variation to amend the European Marketing Authorization Application for XTANDI® (enzalutamide) capsules for the treatment of adult men with metastatic castration-resistant prostate cancer (mCRPC) who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy and in whom chemotherapy is not yet clinically indicated. [More]
Kidney disease patients with poor quality of life at increased risk of developing heart problems

Kidney disease patients with poor quality of life at increased risk of developing heart problems

Kidney disease patients with poor quality of life are at increased risk of experiencing progression of their disease and of developing heart problems, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. The findings suggest that quality of life measurements may have important prognostic value in these individuals. [More]
Eating watermelon reduces blood pressure in overweight individuals

Eating watermelon reduces blood pressure in overweight individuals

Be sure to pick up a watermelon - or two - at your neighborhood farmers' market. It could save your life. [More]
UCSF/Daiichi Sankyo establish drug-discovery collaboration focused on neurodegenerative diseases

UCSF/Daiichi Sankyo establish drug-discovery collaboration focused on neurodegenerative diseases

Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo) and UC San Francisco (UCSF) announced today that they have established a drug-discovery collaboration focused on developing novel therapeutics and molecular diagnostics for multiple neurodegenerative diseases. [More]
Adherent Health announces results of 2014 Patient Preference Study

Adherent Health announces results of 2014 Patient Preference Study

Adherent Health, LLC, a mobile health engagement advisory focused on medication safe-use, adherence, and health outcomes attainment, announced today the results of its 2014 Patient Preference Study which surveyed the mobile app behaviors and medication support preferences of 2,216 prescription-taking patients aged 18-65+. [More]
Recommended daily sodium intake harmful for health, study finds

Recommended daily sodium intake harmful for health, study finds

A new study published in the American Journal of Hypertension finds evidence that the average daily sodium intake of most Americans is actually associated with better health outcomes than intake levels currently recommended by the CDC and major health departments, which are now being viewed by many in the scientific community as excessively and unrealistically low. [More]

Ablative Solutions’ Peregrine System Infusion Catheter receives FDA clearance

Ablative Solutions, Inc., a privately-held clinical stage company, announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Peregrine System(TM) Infusion Catheter. [More]
Report describes cardiopulmonary arrest in infant following cyclopentolate eyedrops

Report describes cardiopulmonary arrest in infant following cyclopentolate eyedrops

Eyedrops administered to infants as part of routine outpatient retinopathy of prematurity (ROP) screening can have life-threatening consequences. A case report published in the current issue of the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) describes cardiopulmonary arrest in a 27-week-old infant following administration of three sets of cyclopentolate 0.2%/phenylephrine 1% (Cyclomydril) eyedrops. [More]

Ablative Solutions' Peregrine System Infusion Catheter receives FDA clearance

Ablative Solutions, Inc., a privately-held clinical stage company, announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration for its Peregrine System™ Infusion Catheter. [More]
Northwestern University awarded NIH grant to conduct phase III Parkinson's neuroprotective study

Northwestern University awarded NIH grant to conduct phase III Parkinson's neuroprotective study

Tanya Simuni, M.D., medical director of Northwestern University's Parkinson's Disease and Movement Disorders Center, was awarded a grant from the National Institutes of Health to conduct a $16 million phase III study of the safety and efficacy of the drug isradipine as a potential neuroprotective agent in Parkinson's disease. [More]

Rigorous blood pressure control could halve recurrent stroke risk

Ensuring that the blood pressure of stroke survivors is controlled at least three-quarters of the time may halve their risk of a recurrence, shows a secondary analysis of the VISP trial. [More]
Enrollment commences for Daiichi Sankyo's ENSURE-AF multinational phase 3 study in NVAF patients

Enrollment commences for Daiichi Sankyo's ENSURE-AF multinational phase 3 study in NVAF patients

Daiichi Sankyo Company, Limited today announced that it has started enrolling patients into the ENSURE-AF multinational phase 3 study, which will evaluate the efficacy and safety of its investigational oral, once-daily direct factor Xa-inhibitor edoxaban compared to enoxaparin/warfarin for the prevention of stroke and other blood clot complications in patients with non-valvular atrial fibrillation (NVAF) undergoing electrical cardioversion (low-energy shocks to trigger normal heart rhythm). [More]

SEATTLE II study confirms safety and efficacy of thrombolytic therapy for acute PE

EKOS Corporation, a BTG International group company, notes the presentation of the results of the SEATTLE II trial this afternoon at ACC.14, the 63rd Annual Scientific Session and Exposition of the American College of Cardiology in Washington, DC in the United States. [More]
Researchers quantify proportion of adults potentially affected by updated 2014 BP recommendations

Researchers quantify proportion of adults potentially affected by updated 2014 BP recommendations

Applying the updated 2014 blood pressure (BP) guideline to the U.S. population suggests that nearly 6 million adults are no longer classified as needing hypertension medication, and that an estimated 13.5 million adults would now be considered as having achieved goal blood pressure, primarily older adults, according to a JAMA study released online to coincide with the 2014 American College of Cardiology Scientific Sessions. [More]

Millions of US adults may no longer need blood pressure medication, study suggests

New guidelines that ease the recommended blood pressure could result in 5.8 million U.S. adults no longer needing hypertension medication, according to an analysis by Duke Medicine researchers. [More]

Poor blood pressure control increases stroke risk in patients with atrial fibrillation

Poor blood pressure control among patients with atrial fibrillation is associated with a 50-percent increased risk of stroke, according to an analysis presented by Duke Medicine researchers. [More]
Women who drink too many diet drinks a day more likely to have heart problems

Women who drink too many diet drinks a day more likely to have heart problems

It appears healthy postmenopausal women who drink two or more diet drinks a day may be more likely to have a heart attack, stroke or other cardiovascular problems, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session. [More]
Research roundup: Distance from a transplant center; Medicaid prenatal care; metastasis of email; profiting from Medicare Advantage

Research roundup: Distance from a transplant center; Medicaid prenatal care; metastasis of email; profiting from Medicare Advantage

Centralization of specialized health care services such as organ transplantation and bariatric surgery is advocated to improve quality, increase efficiency, and reduce cost. [More]

Heart problems less likely for spouses than for single people

People who are married have lower rates of several cardiovascular diseases compared with those who are single, divorced or widowed, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session. The relationship between marriage and lower odds of vascular diseases is especially pronounced before age 50. [More]