Hypoplastic Left Heart Syndrome News and Research

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Hypoplastic left heart syndrome (HLHS) is a problem with the heart’s structure that is present at birth (congenital). It is a group of related defects that, together, mean that the left side of the heart is underdeveloped. Normally, oxygen-poor blood is pumped through the right side of the heart to the lungs, where it gains oxygen and returns to the left side of the heart. The oxygen-rich blood is then pumped from the left side of the heart to the rest of the body. At birth, all babies also have two connections, or shunts, between the two sides of the heart; however, within a few days of birth these connections close.

Injectable hydrogel can mitigate right ventricular heart failure

An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journal of the American College of Cardiology: Basic to Translational Science.

6 Mar 2024

Single-ventricle physiology correlates with higher short-term mortality among adult congenital heart disease transplant recipients

UCLA-led research finds that among adult congenital heart disease (CHD) transplant recipients, single-ventricle physiology correlated with higher short-term mortality.

12 Sep 2023

Researchers find new genes that contribute to hypoplastic left heart syndrome

By identifying genes in patients and testing their effects in fruit flies, researchers from Sanford Burnham Prebys have found new genes that contribute to hypoplastic left heart syndrome (HLHS), a rare, life-threatening heart disease that occurs in infants.

17 Jul 2023

Research shows redlining's long-term impact on cardiovascular health of Black adults

The risk of heart failure in the present day was higher among Black adults who lived in U.S. zip codes historically impacted by redlining, according to research published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

17 Jul 2023

Shattered dreams and bills in the millions: Losing a baby in America

The day after his 8-month-old baby died, Kingsley Raspe opened the mail and found he had been sent to collections for her care.

23 Sep 2022

The successful transplantation of genetically engineered pig hearts into recently deceased humans

Researchers successfully transplanted two genetically engineered heart pigs into recently deceased humans in June and July 2022.

14 Jul 2022

Research on genetic heart disease uncovers new mechanism for heart failure

Research on genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

19 Nov 2020

New tool can encourage more hospitals to be transparent about cardiac outcomes

Congenital Heart Disease (CHD) is the most common birth defect in the United States, occurring in approximately one in every 100 babies.

16 Oct 2020

Study reports potential therapeutic target for lethal heart defect in children

When children are born with hypoplastic left heart syndrome (HLHS), they require a series of major surgical procedures to survive. But even with a repaired heart, as many as one in four children die from complications before age 25.

18 Aug 2020

Study shows home monitoring program improves survival rates in infants with heart defects

Interstage Home Monitoring (IHM) programs for infants with single ventricle heart defects help families recognize potential complications early and improve infant survival rates and growth prior to the second of multiple surgeries.

11 Aug 2020

New collaboration aims to provide solutions for patients with hypoplastic left heart syndrome

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

25 Nov 2019

Clinical study demonstrates potential of regenerative therapy for hypoplastic left heart syndrome

A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.

24 Jul 2019

Alzheimer's Association awards $3 million grant to support Longeveron's innovative clinical trial

The Alzheimer's Association has awarded Longeveron LLC, a Miami-based biopharmaceutical company that develops cellular therapies for aging-related diseases, a $3 million grant to be applied to the company's mesenchymal stem cell Alzheimer's research.

23 Jul 2019

Ochsner Hospital for Children joins national consortium to provide solutions for hypoplastic left heart syndrome

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Ochsner Hospital for Children are collaborating within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

17 Jun 2019

Hispanic infants with congenital heart disease have worse outcomes, research finds

Hispanic infants with critical types of congenital heart disease have worse outcomes in their first year than do their non-Hispanic white counterparts, a difference largely driven by their mother's level of education and type of insurance coverage, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

10 Oct 2018

Mesoblast’s MPC therapy for children featured at symposium for congenital heart disease

Mesoblast Limited today announced that Mesoblast's proprietary allogeneic mesenchymal precursor cell heart failure product candidate MPC-150-IM for use in children with hypoplastic left heart syndrome was featured at the First Cardiac Regenerative Symposium for Congenital Heart Disease in Baltimore, Maryland on the weekend.

26 Sep 2018

Impaired maternal-fetal environment associated with lower survival after surgery in newborns with CHD

Children who undergo surgery for congenital heart disease have lower survival rates by three years of age if there are specific problems during fetal development, such as hypertension in the mother or the newborn being born preterm or small for gestational age.

30 May 2018

Gout medication may help improve heart function in adult patients

Researchers at the University of Cincinnati College of Medicine have shown that probenecid, a drug long used to treat gout, may be able to improve heart function in adult patients who experience heart failure.

20 Feb 2018

CHLA participates in clinical trial using stem cells to treat rare congenital heart defect

Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart.

5 Feb 2018

Pitt scientists discover genes responsible for severe congenital heart disease

The first known identification of two genes responsible for hypoplastic left heart syndrome (HLHS), a severe congenital heart defect, has been reported by researchers at the University of Pittsburgh School of Medicine.

22 May 2017