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Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

The study in Nature Microbiology reviews the concept of immune imprinting and its influence on antibody responses to SARS-CoV-2, highlighting challenges for COVID-19 booster vaccination efficacy against emerging variants. Researchers suggest that understanding immune imprinting is crucial for developing vaccines that elicit broad and lasting immune protection.

7 Nov 2023

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

A two-year longitudinal study highlights proteomic changes in long-COVID patients, revealing potential biomarkers for diagnosis and shedding light on the persistent physiological challenges faced by survivors.

7 Nov 2023

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

Comprehensive review unravels the complexities of long COVID, spanning pathophysiology to management strategies, and underscores the need for targeted therapies and early diagnosis.

5 Nov 2023

High-impact clinical trial results to be presented at ASN Kidney Week 2023

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2023 November 1–November 5.

3 Nov 2023

Balancing act: Navigating elimination diets in allergic kids without compromising nutrition

Recent research underscores the importance of careful management of elimination diets in children with food allergies, ensuring nutritional balance and support for growth. The study advocates for a multidisciplinary approach to help children avoid allergens without compromising their overall health and development.

2 Nov 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

How strep bacteria outsmart your immune system and why it matters for treatment

Researchers discover that Group A streptococcal infections alter immunoglobulin G (IgG) homeostasis to evade the immune system, affecting the transition from local to systemic infections. The study also raises concerns about the effectiveness of antibody-based therapies, as the bacteria's virulence factors can degrade therapeutic antibodies.

25 Oct 2023

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

A single-dose intranasal vaccine effectively induces robust immune responses.

24 Oct 2023

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Located in the mucus layer that lines the gastrointestinal tract, mucins-;proteins with attached sugar molecules-;play a key role in combating bacterial infection and providing a safe haven to friendly gut bacteria through unknown mechanisms.

11 Oct 2023

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Researchers used a genetically engineered porcine donor to develop kidney grafts.

11 Oct 2023

Do prebiotics and probiotics positively impact cardiovascular and renal health?

The benefits of consuming nutrients, prebiotics, and probiotics to enhance cardiovascular and renal health.

11 Oct 2023

Breast milk microbiome changes after COVID-19 vaccination, linked to enhanced infant protection

Study explored the association between BNT162b2 vaccine-induced antibodies and the breast milk microbiome in 49 breastfeeding mothers, revealing that post-vaccination alterations in the microbiome were linked to humoral protection against SARS-CoV-2.

9 Oct 2023

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.

8 Oct 2023

Novel vaccine lowers LDL cholesterol independent of statins

The effectiveness of virus-like particle (VLP)-based vaccines targeting epitopes in the low-density lipoprotein (LDL) receptor.

2 Oct 2023

Ginger shows promise as a natural defense against autoimmune diseases

Comprehensive study reveals that whole ginger extracts have a significant impact on inhibiting neutrophil hyperactivity, a key factor in autoimmune diseases like APS and lupus. Consuming ginger for just a week showed promising results in both animal models and human trials, positioning it as a natural and affordable treatment option for a range of autoimmune disorders.

2 Oct 2023

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Study highlights the ability of the Vaxzevria vaccine in inducing robust mucosal antibody responses, especially in COVID-19-recovered individuals, showcasing a notable defense against various SARS-CoV-2 variants. However, it emphasizes the need for booster doses to enhance anti-SARS-CoV-2 mucosal immunity, especially in infection-naïve individuals, to broaden protection against emerging viral variants.

28 Sep 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Long COVID's biological blueprint: new study offers promising insights

Researchers designed a cross-sectional study to investigate the biological underpinnings of “Long COVID”, the post-acute infection syndrome triggered by SARS-CoV-2.

27 Sep 2023

Immunoglobulin News and Research

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

High-impact clinical trial results to be presented at ASN Kidney Week 2023

Balancing act: Navigating elimination diets in allergic kids without compromising nutrition

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Redefining the battle against Alzheimer's with tau-focused treatments

How strep bacteria outsmart your immune system and why it matters for treatment

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Do prebiotics and probiotics positively impact cardiovascular and renal health?

Breast milk microbiome changes after COVID-19 vaccination, linked to enhanced infant protection

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Novel vaccine lowers LDL cholesterol independent of statins

Ginger shows promise as a natural defense against autoimmune diseases

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

Long COVID's biological blueprint: new study offers promising insights

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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