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Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. [More]
NIH researchers discover rare, lethal inflammatory disease that affects young children

NIH researchers discover rare, lethal inflammatory disease that affects young children

National Institutes of Health researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children. They have also identified anti-inflammatory treatments that ease some of the patients' symptoms: fever, skin rashes, diarrhea, joint pain and overall failure to grow or thrive. [More]
DASH diet could be effective, non-pharmacologic approach to prevent gout flares

DASH diet could be effective, non-pharmacologic approach to prevent gout flares

New research indicates that a healthy diet can effectively lower blood levels of uric acid, a known trigger of gout. The findings are published in Arthritis & Rheumatology, a journal of the American College of Rheumatology . [More]
Hidden dental root tip infections may increase risk of coronary artery disease

Hidden dental root tip infections may increase risk of coronary artery disease

According to a study carried out at the University of Helsinki, an infection of the root tip of a tooth increases the risk of coronary artery disease, even if the infection is symptomless. [More]
Psoriasis treatments may help improve cardiovascular symptoms by reducing skin inflammation

Psoriasis treatments may help improve cardiovascular symptoms by reducing skin inflammation

Approximately 7.5 million people in the United States have psoriasis, and the impact of this disease goes far beyond its visible effects on the skin. [More]
Researchers develop first protective vaccine against insidious STI

Researchers develop first protective vaccine against insidious STI

The first steps towards developing a vaccine against an insidious sexual transmitted infection (STI) have been accomplished by researchers at McMaster University. [More]
New study finds link between periodontal disease and lacunar stroke

New study finds link between periodontal disease and lacunar stroke

A new study has revealed a relationship between chronic periodontitis and lacunar infarct, two common diseases in the elderly. Chronic periodontitis is an inflammatory disease of the gums, whereas lacunar infarct is a type of cerebral small vessel disease that can lead to a stroke. [More]
Study identifies new blood markers to accurately diagnose Gulf War Illness

Study identifies new blood markers to accurately diagnose Gulf War Illness

Based on a study of 85 Gulf War veterans, Veterans Affairs researchers in Minneapolis have developed a tentative panel of blood markers they say can verify a diagnosis of Gulf War Illness with 90 percent accuracy. [More]
Scientists identify epigenetic alterations involved in autoinflammatory diseases

Scientists identify epigenetic alterations involved in autoinflammatory diseases

Researchers from the Chromatin and Disease group of the Bellvitge Biomedical Research Institute, led by Dr. Esteban Ballestar, have identified for the first time epigenetic alterations in autoinflammatory diseases, particularly in cryopyrin-associated periodic syndromes (CAPS). [More]
Sleep disturbances, long sleep duration linked to inflammatory illnesses

Sleep disturbances, long sleep duration linked to inflammatory illnesses

A new meta-analysis in Biological Psychiatry reports that sleep disturbances and long sleep duration are associated with increases in markers of inflammation. [More]
Study demonstrates role of leukocyte activation receptor CD69 in development of psoriasis

Study demonstrates role of leukocyte activation receptor CD69 in development of psoriasis

Scientists at the Centro de Investigaciones Cardiovasculares Carlos III have defined the key role of an immune-system receptor in the development of psoriasis, suggesting that it could serve as a therapeutic target for the control of this disease. [More]
New study may help develop effective medication for severe pain

New study may help develop effective medication for severe pain

The nerve cells that transmit pain signals in the body are called nociceptors. When activated they release pro-inflammatory neuropeptides. In order to recognise harmful external influences, nociceptors are equipped with a wide range of receptors. [More]
Researchers develop in vitro model system for investigating etiology of NAFLD

Researchers develop in vitro model system for investigating etiology of NAFLD

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD). [More]
TUM scientists identify four new risk genes altered in MS patients

TUM scientists identify four new risk genes altered in MS patients

Scientists of the Technical University of Munich and the Max Planck Institute of Psychiatry have identified four new risk genes that are altered in German patients with multiple sclerosis (MS). [More]
PET imaging can help identify autoimmune inflammation in MS

PET imaging can help identify autoimmune inflammation in MS

The triggers of autoimmune inflammation in multiple sclerosis (MS) have eluded scientists for many years, but molecular imaging is bringing researchers closer to identifying them, while providing a means of evaluating next-generation therapies for MS, say researchers introducing a study at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. [More]
New stem cell treatment may halt clinical relapses, development of new brain lesions in patients MS

New stem cell treatment may halt clinical relapses, development of new brain lesions in patients MS

A new use of chemotherapy followed by autologous haematopoietic stem cell transplantation (aHSCT) has fully halted clinical relapses and development of new brain lesions in 23 of 24 patients with multiple sclerosis (MS) for a prolonged period without the need for ongoing medication, according to a new phase 2 clinical trial, published in The Lancet. [More]
Women with SLE may have increased cervical cancer risk

Women with SLE may have increased cervical cancer risk

The results of a study presented today at the European League Against Rheumatism Annual Congress found a doubled risk of pre-malignant cervical changes, and potentially also an increased risk of cervical cancer, among women with Systemic Lupus Erythematosus (SLE) compared to the general female population. [More]
New drug ixekizumab helps clear severe psoriasis symptoms

New drug ixekizumab helps clear severe psoriasis symptoms

About 80 percent of patients with moderate to severe psoriasis saw their disease completely or almost completely cleared with a new drug called ixekizumab, according to three large, long-term clinical trials led by Northwestern Medicine. [More]
Joint research reveals key mechanisms of persistent latent infection of HTLV-1

Joint research reveals key mechanisms of persistent latent infection of HTLV-1

Joint research between scientists from Kumamoto University, Japan and Imperial College London, UK has revealed the mechanisms of persistent latent infection of the human T-cell leukemia virus type 1 (HTLV-1). [More]
Gonorrhoea infections increase across Europe

Gonorrhoea infections increase across Europe

Since 2008, the overall rate of reported gonorrhoea infections has more than doubled across Europe, going up from 8 per 100 000 population to 20 cases per 100 000 persons in 2014. [More]
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