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Infliximab is a monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer. It belongs to the family of drugs called monoclonal antibodies.

TNF therapy does not raise cancer risk in RA patients; overall cancer risk comparable to those not taking immunosuppressive drugs

29. October 2009 01:00
A recent study by Swedish researchers found that rheumatoid arthritis (RA) patients did not experience an elevated cancer risk in the first 6 years after starting anti-tumor necrosis factor (TNF) therapy. [More]

New data from CIMZIA WELCOME trial to be presented at the ACG meeting

28. October 2009 08:22
According to new results from the WELCOME trial, exploratory data analyzing the impact of treatment with CIMZIA(®) (certolizumab pegol) - the only PEGylated anti-TNF (alpha) (Tumor Necrosis Factor alpha) - administered either every two weeks or every four weeks, showed that the majority of Crohn's disease patients in both dosing groups experienced no hospitalizations and surgical procedures during the course of the 26-week study. [More]

Report on the future market potential for monoclonal antibodies

27. October 2009 08:28
Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment [More]

New data on Phase 3 SIMPONI clinical trials for rheumatoid arthritis

19. October 2009 09:41
New long-term data from two pivotal, Phase 3 clinical trials showed that patients with active rheumatoid arthritis (RA) receiving SIMPONI(TM) (golimumab) every four weeks achieved sustained improvements in signs and symptoms and physical function response through one year. These new data were presented today at the 2009 American College of Rheumatology (ACR) Annual Scientific Meeting. [More]

Johnson & Johnson announces financial results for the third quarter of 2009

13. October 2009 08:07
Johnson & Johnson today announced sales of $15.1 billion for the third quarter of 2009, a decrease of 5.3% as compared to the third quarter of 2008. Operational results declined 2.8% and the negative impact of currency was 2.5%. Domestic sales declined 8.1%, while international sales declined 2.5%, reflecting operational growth of 2.4% and a negative currency impact of 4.9%. [More]

More studies needed to compare the efficacy of different biologic drugs for RA, say researchers

7. October 2009 04:34
More studies that directly compare the effectiveness of different biologic drugs for rheumatoid arthritis (RA) are needed, say Cochrane Researchers. The researchers reviewed all previous Cochrane Systematic Reviews assessing the effectiveness of biologic disease-modifying drugs for treatment of RA and found that although all were very effective, there was little data on direct comparisons between the drugs that could help doctors decide which to prescribe. [More]

Mayo study reveals infliximab reduces the need for colectomy

1. October 2009 09:39
A new study led by Mayo Clinic researchers has found that ulcerative colitis patients had a 41 percent reduction in colectomy after a year when treated with infliximab, according to a study published in the October 2009 issue of Gastroenterology. [More]

Reportlinker's medical review criteria guidelines for managing care

30. September 2009 08:03
Reportlinker Adds Medical Review Criteria Guidelines for Managing Care (8th ed. - 2009) [More]

Posted in: Healthcare News

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Comprehensive and practical overview of psoriasis

22. September 2009 06:00
Treatments for psoriasis often present a therapeutic challenge to physicians because, besides affecting the skin, psoriasis may be associated with various comorbidities (for instance, depression, psoriatic arthritis, Crohn's disease and, in severe psoriasis, metabolic syndrome and cardiovascular diseases). [More]

Report on autoimmune disease therapeutics in worldwide markets

9. September 2009 04:08
Reportlinker.com announces that a new market research report is available in its catalogue. Autoimmune Disease Therapeutics [More]

New report on the psoriasis market offered by Research and Markets

4. September 2009 05:15
Research and Markets (http://www.researchandmarkets.com/research/b8d445/commercial_insight) has announced the addition of the "Commercial Insight: Psoriasis - Intellectual property drives growth" report to their offering. [More]

Golimumab shows promise for rheumatoid arthritis

28. June 2009 21:37
Golimumab, a new tumour necrosis factor-α (TNF-α) inhibitor reduces the signs and symptoms of rheumatoid arthritis in patients who have previously received any other TNF-α inhibitor, and might be a good option for patients who have inadequate responses to one or two other TNF-α inhibitors, finds an Article published Online first and in this week's edition of The Lancet. [More]

Posted in: Drug Trial News

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Impact of Medicare Part D on access to and cost sharing for specialty biologic medications for beneficiaries with rheumatoid arthritis

1. June 2009 19:33
Biologic disease-modifying antirheumatic drugs (DMARDs) such as adalimumab, etanercept and infliximab are effective at reducing symptoms and slowing progression of rheumatoid arthritis (RA). These drugs act more quickly, require less laboratory monitoring, and are better tolerated than nonbiologic DMARDs, but they are also up to 100 times more expensive. [More]

Posted in: Pharmaceutical News

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Researchers identify mechanism by which an anti-TNF therapy impairs host defense against tuberculosis

20. April 2009 23:06
The life of many individuals with inflammatory diseases such as rheumatoid arthritis has been dramatically improved by treatment with drugs that target the protein TNF, so called anti-TNF therapies. [More]

Posted in: Medical Research News

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Infliximab after intestinal resective surgery may help prevent post-op Crohn's disease recurrence

2. February 2009 12:29
The administration of infliximab after intestinal resective surgery was found to be effective at preventing endoscopic and histological recurrence of Crohn's disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. [More]

Posted in: Drug Trial News

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