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A kidney transplant is an operation where a healthy kidney from one person (the donor) is transferred to a person who has little or no kidney function (the recipient).
CHOP surgeons successfully complete world's first bilateral hand transplant on child

CHOP surgeons successfully complete world's first bilateral hand transplant on child

Surgeons at The Children's Hospital of Philadelphia joined with colleagues from Penn Medicine recently to complete the world's first bilateral hand transplant on a child. Earlier this month, the surgical team successfully transplanted donor hands and forearms onto eight-year-old Zion Harvey who, several years earlier, had undergone amputation of his hands and feet and a kidney transplant following a serious infection. [More]
NEJM suggests use of HCV-positive kidneys as one solution to kidney shortage

NEJM suggests use of HCV-positive kidneys as one solution to kidney shortage

The average wait time for a kidney transplant is five years and there are more than 100,000 people on the waiting list. However, there are thousands of viable hepatitis C-positive kidneys that are discarded each year solely because they're infected. [More]
UC San Diego researchers identify pivotal player in diabetic kidney disease

UC San Diego researchers identify pivotal player in diabetic kidney disease

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease. [More]
Wayne State researchers explore effects of Tocotrienol-rich fraction from palm oil in ESRD patients

Wayne State researchers explore effects of Tocotrienol-rich fraction from palm oil in ESRD patients

End-stage renal disease (ERSD) is the last stage of chronic kidney disease where the kidneys function at under 10 to 15 percent of their normal capacity. At this stage, kidneys cannot effectively remove waste or excess fluid from the blood system, and dialysis or a kidney transplant is necessary to live. [More]
Envarsus XR receives FDA approval for treatment of kidney transplant recipients

Envarsus XR receives FDA approval for treatment of kidney transplant recipients

Veloxis Pharmaceuticals A/S today announced U.S. Food and Drug Administration approval of Envarsus XR (tacrolimus extended-release tablets) for the prophylaxis of rejection in kidney transplant patients who require or desire conversion from other twice-daily tacrolimus products to once-daily Envarsus XR. [More]
Study could provide paradigm shift in treatment of age-related disease, cancer

Study could provide paradigm shift in treatment of age-related disease, cancer

Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies. [More]

Clinical support for kidney perfusion

Lifeline Scientific (AIM: LSIC), the transplantation technology company, welcomes the publication in Experimental and Clinical Transplantation of the clinical study (‘Study’): “Hypothermic Machine Perfusion Permits Extended Cold Ischemia Times With Improved Early Graft Function.” [More]
Scientists reveal why lone kidney gets bigger when the other one is lost

Scientists reveal why lone kidney gets bigger when the other one is lost

Scientists have found an explanation for the century-old observation that if you end up with just one kidney, the lone organ gets bigger. [More]
Effimune obtains regulatory approval for Phase I clinical trial in humans of its new immunomodulator FR104

Effimune obtains regulatory approval for Phase I clinical trial in humans of its new immunomodulator FR104

Effimune announced today that it had received the authorization from the Belgian regulatory authority, the FAMHP (Federal Agency for Medicines and Health Products) for a Phase I clinical trial of FR104, its drug candidate for controlling the regulation of the immune system... [More]
Testing APOL1 gene variants in deceased kidney donors may improve transplant outcomes

Testing APOL1 gene variants in deceased kidney donors may improve transplant outcomes

Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by researchers at Wake Forest Baptist Medical Center. [More]
CUMC researchers identify mechanism of kidney transplant tolerance

CUMC researchers identify mechanism of kidney transplant tolerance

Columbia University Medical Center researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs, a significant step toward reducing or eliminating the need for costly and potentially toxic immunosuppressant drugs and improving long-term transplant success. [More]
Today’s “World Kidney Day” promotes kidney health for all

Today’s “World Kidney Day” promotes kidney health for all

Recent surveys have shown that the general public’s understanding about what our kidneys do and what the risk factors for kidney disease are, is astoundingly poor. In the UK, five leading kidney charities are joining forces in the campaign “Kidney Charities Together,” which calls for urgent action to be taken to raise awareness of kidney disease. [More]
1 in 5 of the UK population could be walking around with ‘ticking time bomb’

1 in 5 of the UK population could be walking around with ‘ticking time bomb’

Kidney Research UK polled 2,000 adults across the UK to find out just how much people know about the disease. Startlingly, almost three quarters (74%) of those polled claim to have limited or no knowledge of kidney disease, its causes or its symptoms. [More]
EMA's CHMP backs JINARC (tolvaptan) for autosomal dominant polycystic kidney disease

EMA's CHMP backs JINARC (tolvaptan) for autosomal dominant polycystic kidney disease

Otsuka Pharmaceutical Co., Ltd. announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended JINARC (tolvaptan) for approval. [More]
Diets high in animal proteins can worsen progression of kidney disease

Diets high in animal proteins can worsen progression of kidney disease

An estimated 26 million people in the United States have chronic kidney disease, which can lead to complete kidney failure. Once the kidneys fail, patients either need to undergo dialysis treatments three times a week or have a kidney transplant to remain alive. [More]
Urinary levels of novel biomarkers linked to adverse long-term outcomes in AKI patients

Urinary levels of novel biomarkers linked to adverse long-term outcomes in AKI patients

High levels of two novel urinary biomarkers early in critical illness are associated with adverse long-term outcomes in patients with acute kidney injury (AKI), according to an international, multi-center study led by University of Pittsburgh School of Medicine Researchers. [More]
Dallas Cowboys timekeeper ready to get back to work after kidney transplant at UT Southwestern

Dallas Cowboys timekeeper ready to get back to work after kidney transplant at UT Southwestern

Jim Ely tackles life like Mean Joe Greene tackled running backs. A banker, he also worked weekends as a football referee for 38 years and still, at age 83, works as home-game timekeeper for the Dallas Cowboys. [More]
New therapeutic targets can prevent scarring within transplanted kidneys

New therapeutic targets can prevent scarring within transplanted kidneys

Kidneys donated by people born with a small variation in the code of a key gene may be more likely, once in the transplant recipient, to accumulate scar tissue that contributes to kidney failure, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published today in the Journal of Clinical Investigation. [More]
Alport syndrome: an interview with Dr Paul Grint, CMO, Regulus

Alport syndrome: an interview with Dr Paul Grint, CMO, Regulus

Alport Syndrome was first described by a physician called Cecil Alport, back in the late 1920s. It's a genetic disease that affects a certain type of collagen involved in the functioning of the kidney, the ear, and the eye. [More]
Frailty: A strong risk factor for dying prematurely after kidney transplant

Frailty: A strong risk factor for dying prematurely after kidney transplant

Regardless of age, frailty is a strong risk factor for dying prematurely after a kidney transplant. The finding, which comes from a new study published in the American Journal of Transplantation, suggests that patients should be screened for frailty prior to kidney transplantation, and that those who are identified as frail should be closely monitored after the procedure. [More]
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