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New research pinpoints key pathways in prostate cancer's vulnerability to ferroptosis

Review examines the role of ferroptosis, an iron-dependent form of cell death, in prostate cancer, exploring its underlying molecular mechanisms and potential for targeted therapeutic strategies.

17 Apr 2024

Study identifies genomic variant linked to unique human skull base morphology

Humans, Homo sapiens, have unique features compared with other closely related hominin species and primates, including the shape of the base of the skull.

17 Apr 2024

Ketamine's rapid impact on depression linked to immune system pathways

Study reveals ketamine's potent anti-inflammatory effects on neurological disorders, showing promise for treating major depressive disorder through modulation of neuroimmune pathways.

15 Apr 2024

First comprehensive atlas sheds new light on processes underlying age-related muscle changes

How muscle changes with aging, and tries to fight its effects, is now better understood at the cellular and molecular level with the first comprehensive atlas of aging muscles in humans.

15 Apr 2024

Study unlocks genetic secrets in APOEε4 carriers that could defend against Alzheimer's

Researchers utilized whole-genome sequencing and pathway analysis to uncover protective genetic variations against Alzheimer's disease in APOEε4 carriers, revealing a crucial role for extracellular matrix-related genes in mitigating the disease's progression.

15 Apr 2024

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

miR-205 knockout surprises with enhanced mammary development and cancer insights

New research unveils the paradoxical role of miR-205 in mammary gland development and its potential impact on breast cancer, highlighting the miRNA's complex involvement in stem cell regulation and tumor suppression.

2 Apr 2024

DNA repair process key to memory formation, study finds

Study reveals that learning triggers a series of molecular events including DNA damage and repair in hippocampal neurons, mediated by TLR9, crucial for memory formation.

31 Mar 2024

Familial Alzheimer's transmissible through bone marrow transplants, study shows

Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show March 28 in the journal Stem Cell Reports.

28 Mar 2024

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer.

22 Mar 2024

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

15 Mar 2024

Study highlights potential therapeutic target for immune-related disorders

A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma.

11 Mar 2024

Key brain cells linked to repetitive behaviors in psychiatric diseases

Crym-expressing astrocytes in the striatum have been identified as key regulators of behaviors often seen in neuropsychiatric diseases, opening up new avenues for targeted therapies.

6 Mar 2024

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Knockout News and Research

New research pinpoints key pathways in prostate cancer's vulnerability to ferroptosis

Study identifies genomic variant linked to unique human skull base morphology

Ketamine's rapid impact on depression linked to immune system pathways

First comprehensive atlas sheds new light on processes underlying age-related muscle changes

Study unlocks genetic secrets in APOEε4 carriers that could defend against Alzheimer's

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

miR-205 knockout surprises with enhanced mammary development and cancer insights

DNA repair process key to memory formation, study finds

Familial Alzheimer's transmissible through bone marrow transplants, study shows

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Study highlights potential therapeutic target for immune-related disorders

Key brain cells linked to repetitive behaviors in psychiatric diseases

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Identification of genetic determinants of micronucleus formation

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

bit.bio to showcase its ioCRISPR-Ready CellsTM products at the SLAS 2024 international conference and exhibition

New study identifies key role of microRNA-29 in scar-free wound healing

CRISPR revolutionized: New method edits genes directly in the body

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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