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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.
Mice fed with omega 3 fatty acids have healthier joints

Mice fed with omega 3 fatty acids have healthier joints

Mice consuming a supplement of omega 3 fatty acids had healthier joints than those fed diets high in saturated fats and omega 6 fatty acids, according to Duke Medicine researchers. [More]
Rockefeller scientists identify protein that makes breast cancer cells more likely to metastasize

Rockefeller scientists identify protein that makes breast cancer cells more likely to metastasize

Using an innovative tool that captures heretofore hidden ways that cells are regulated, scientists at Rockefeller University have identified a protein that makes breast cancer cells more likely to metastasize. [More]
Telephone-based weight loss intervention is effective in breast cancer treatments

Telephone-based weight loss intervention is effective in breast cancer treatments

A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese, published online today in Journal of Clinical Oncology by Dr. Pamela Goodwin of Mount Sinai Hospital and the Lunenfeld-Tanenbaum Research Institute. [More]
Proteins causing daytime sleepiness also play crucial role in bone formation

Proteins causing daytime sleepiness also play crucial role in bone formation

Orexin proteins, which are blamed for spontaneous daytime sleepiness, also play a crucial role in bone formation, according to findings by UT Southwestern Medical Center researchers. [More]
People with obesity gene FTO tend to gain more weight as they age

People with obesity gene FTO tend to gain more weight as they age

A new study from Uppsala University demonstrates that elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight. [More]
New data shows adult America is 55% obese, not 35%

New data shows adult America is 55% obese, not 35%

On the heels of the wake-up call from 'FED UP', the just released documentary on obesity, it is no surprise that the CDC's (U.S. Center for Disease Control) obesity statistics are grossly under reported. Meredith [More]
Yale researchers find that hormone leptin may help treat metabolic disorders

Yale researchers find that hormone leptin may help treat metabolic disorders

Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, Yale School of Medicine researchers have found that the hormone also acts on other types of cells to control appetite. [More]
Researchers discover how gene commonly linked to obesity contributes to weight gain

Researchers discover how gene commonly linked to obesity contributes to weight gain

Researchers have discovered how a gene commonly linked to obesity—FTO—contributes to weight gain. The study shows that variations in FTO indirectly affect the function of the primary cilium, a little-understood hair-like appendage on brain and other cells. [More]
Two young neuroscientists win CAN Young Investigator Awards for 2014

Two young neuroscientists win CAN Young Investigator Awards for 2014

The Canadian Association for Neuroscience is proud to announce that Dr. Stephanie Borgland, from the Hotchkiss Brain Institute at University of Calgary, and Dr. Brian Chen, from the Centre for Research in Neuroscience at McGill University, are both winners of CAN Young Investigator Awards for 2014. [More]
Professor wins 2014 Outstanding Scientific Achievement Award from American Diabetes Association

Professor wins 2014 Outstanding Scientific Achievement Award from American Diabetes Association

Dr. Joel Elmquist, Director of the Center for Hypothalamic Research at UT Southwestern Medical Center, has been awarded the American Diabetes Association's Outstanding Scientific Achievement Award, the organization's top honor for an early-career scientist. [More]
Professor receives 2014 Rolf Luft Award for research on diabetes and endocrinology

Professor receives 2014 Rolf Luft Award for research on diabetes and endocrinology

Dr. Roger Unger, Professor of Internal Medicine at UT Southwestern Medical Center has been awarded the 2014 Rolf Luft Award for his identification of glucagon as a pancreatic hormone that raises blood sugar levels, having the opposite effect of insulin. [More]
Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. [More]
Teen diagnosed with liver cancer explores genetic link to rare cancers

Teen diagnosed with liver cancer explores genetic link to rare cancers

A father-daughter scientific collaboration that began after the daughter was diagnosed with a rare liver cancer has led to an important finding and could have broader implications for many other rare cancers. Their story is being published this week in a top tier journal, Science. [More]
Obesity, contraceptives pills may increase risk of developing MS in later stages, says study

Obesity, contraceptives pills may increase risk of developing MS in later stages, says study

The role of the so-called "obesity hormone" leptin and hormones used for birth control in the development of multiple sclerosis (MS) is examined in two new studies released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014. [More]
Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline that often accompanies obesity and diabetes can be reversed with regular exercise or surgical removal of belly fat, scientists report. [More]
Researchers identify specific biomarkers of obesity and early-stage colon cancer

Researchers identify specific biomarkers of obesity and early-stage colon cancer

Obesity is a known risk factor for many cancers including colon cancer, yet the reasons behind the colon cancer link have often remained unclear. [More]
High sodium intake correlates with fatness and inflammation in adolescents

High sodium intake correlates with fatness and inflammation in adolescents

Most adolescents consume as much salt as adults - some more than twice the recommended daily allowance - and that high sodium intake correlates with fatness and inflammation regardless of how many calories they consume, researchers report. [More]
Consumption of probiotics could help promote healthy weight in women, says study

Consumption of probiotics could help promote healthy weight in women, says study

Certain probiotics could help women lose weight and keep it off, according to a recent study published in the British Journal of Nutrition by a team of researchers headed by Universit- Laval Professor Angelo Tremblay. [More]
FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

AstraZeneca and Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) recommends the investigational medicine metreleptin for the treatment of pediatric and adult patients with generalized lipodystrophy (LD). [More]
Childhood exercise help mitigate obesity due to prenatal exposure to high-fat diets

Childhood exercise help mitigate obesity due to prenatal exposure to high-fat diets

​Rats whose mothers were fed a high-fat diet during pregnancy and nursing were able to stave off some of the detrimental health effects of obesity by exercising during their adolescence, new Johns Hopkins research shows. [More]