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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.
Physician explains how poor or low-quality sleep hinders common resolutions

Physician explains how poor or low-quality sleep hinders common resolutions

Making New Year's resolutions is easy. Keeping them — beyond a couple of weeks, at least — is tough. [More]
CSHL scientists create first model of genetically induced obesity in fruit flies

CSHL scientists create first model of genetically induced obesity in fruit flies

Why do people become obese? Poor dietary choices and overeating seem like clear causes, but what is at the root of these behaviors? Significantly overweight people may be genetically predisposed to be affected disproportionately when faced with the ready availability of calorie-laden treats. [More]
Study shows effects of intensive weight reduction on normal weight females

Study shows effects of intensive weight reduction on normal weight females

Worries about the potential negative consequences of fat loss regimens for aesthetic purposes in normal weight females have been surfacing in the media. [More]
Western diet during pregnancy may increase obesity risk in offspring

Western diet during pregnancy may increase obesity risk in offspring

Diet composition around the time of pregnancy may influence whether offspring become obese, according to a new study using animal models at The Scripps Research Institute (TSRI). [More]
Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes. [More]
Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

B12 deficiency during pregnancy may predispose children to metabolic problems such as type-2 diabetes, according to research presented today at the Society for Endocrinology's annual Conference in Brighton. [More]
Sleep-deprived people may consume extra calories , study finds

Sleep-deprived people may consume extra calories , study finds

Sleep deprivation may result in people consuming more calories during the following day, according to a systematic review and meta-analysis led by researchers at King's College London. [More]
Research findings raise hope for better treatment of diabetic wounds

Research findings raise hope for better treatment of diabetic wounds

Diabetics often have to contend with wounds that heal poorly. Researchers at the Max Planck Institute for Biology of Ageing, the CECAD Excellence Cluster and the Institute of Genetics of the University of Cologne have now gained fresh insights into the underlying cellular mechanisms. [More]
Study identifies mechanistic link between maternal obesity and childhood hypertension

Study identifies mechanistic link between maternal obesity and childhood hypertension

Exposure of babies to high levels of the 'fullness' hormone, leptin, in the womb irreversibly activates receptors in the brain that regulate blood pressure, according to a new study by researchers from King's College London, part-funded by the British Heart Foundation. [More]
Researchers discover how appetite is controlled and influenced by the brain

Researchers discover how appetite is controlled and influenced by the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain. [More]
Researchers discover potential new therapeutic target for treating obesity

Researchers discover potential new therapeutic target for treating obesity

Scientists at Baylor College of Medicine, the National Institutes of Health and Virginia Tech Carilion Research Institute have discovered a new mechanism in the mouse brain that regulates obesity. [More]
New study reveals endocrine biological function of brown adipose tissue

New study reveals endocrine biological function of brown adipose tissue

Brown adipose tissue -main organ generating heat in the body- is also an endocrine organ that secretes signaling factors that activate the fat and carbohydrates metabolism. [More]
DGIST researchers uncover mechanisms that control appetite during low glucose conditions in the brain

DGIST researchers uncover mechanisms that control appetite during low glucose conditions in the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology (DGIST) in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain. [More]
Scientists manage to produce first molecular map of genes in the pancreas

Scientists manage to produce first molecular map of genes in the pancreas

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. [More]
Exposure to air pollution at place of residence could be risk factor for type 2 diabetes

Exposure to air pollution at place of residence could be risk factor for type 2 diabetes

Exposure to air pollution at the place of residence increases the risk of developing insulin resistance as a pre-diabetic state of type 2 diabetes. [More]
Glia cells may play role in regulating sugar intake into the brain, experts report

Glia cells may play role in regulating sugar intake into the brain, experts report

Researchers at Technical University of Munich discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process. [More]
Maternal GDM linked to increased risk of childhood obesity among children aged 9-11 years

Maternal GDM linked to increased risk of childhood obesity among children aged 9-11 years

New research published in Diabetologia shows an increased risk of childhood obesity at age 9-11 years when the mother has had gestational diabetes during pregnancy. [More]
Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Paternal intake of a high-fat diet (HFD) can cause genetic changes that lead to generational obesity and metabolic dysfunction—including body weight and fat mass increases and changes in blood pressure, triglyceride levels and fat metabolism—in mice, according to Japanese researchers at Okayama University. [More]
Fat cells could help determine most effective way to combat breast cancer

Fat cells could help determine most effective way to combat breast cancer

New research led by York University Professor Michael Connor highlights how fat cells could help determine the most effective way to fight breast cancer; including using exercise to combat the disease. [More]
Moderate caloric restriction in healthy non-obese individuals reduces chronic inflammation

Moderate caloric restriction in healthy non-obese individuals reduces chronic inflammation

Eating less may help us lead longer, healthier lives, according to the new results from a large, multicenter study, led by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. [More]
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