Lipoprotein News and Research

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A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins.

New CETP blockers continue to show promise as viable heart drugs

Mindful of lessons from a failed heart drug that cost $800 million to develop, drug companies are taking another shot at new medications that boost levels of so-called "good cholesterol," which removes cholesterol from the body.

23 Feb 2012

NCQA tool doesn't adequately evaluate quality of diabetes care at health centers

On the health front, the poor often have at least two things going against them: a lack of insurance and chronic illnesses, of which diabetes is among the most common.

16 Feb 2012

Higher levels of MVPA may improve cardiometabolic risk factors in children, adolescents

In a study that included data for more than 20,000 children and adolescents, higher amounts of time with moderate to vigorous physical activity were associated with better cardiometabolic risk factors (such as measures of cholesterol, blood pressure and waist size), regardless of the amount of time spent sedentary, according to a study in the February 15 issue of JAMA.

15 Feb 2012

Scientists identify and describe molecular mechanism behind holoprosencephaly

Researchers of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans. In holoprosencephaly (HPE), the forebrain (prosencephalon) is only incompletely formed.

14 Feb 2012

Kowa announces data of LIVALO vs. Crestor on pharmacodynamics of warfarin

Kowa Pharmaceuticals America, Inc. today announced data assessing the effect of LIVALO (pitavastatin) compared with Crestor (rosuvastatin) on steady-state pharmacodynamics (PD) of warfarin by measuring international normalized ratio (INR) in healthy adult subjects.

14 Feb 2012

Coronary patients with low levels of anti-PC at greater risk of complications

Coronary patients with low levels of an immune system antibody called anti-PC, which neutralises parts of the "bad" cholesterol, run a greater risk of suffering complications following an acute cardiac episode and thus of premature death.

6 Feb 2012

Postmenopausal women at higher risk of stroke than they think

A new study by researchers at NYU Langone Medical Center and colleagues found that traditional risk factors for stroke - such as high cholesterol - are not as accurate at predicting risk in postmenopausal women as previously thought. Instead, researchers say doctors should refocus their attention on triglyceride levels to determine which women are at highest risk of suffering a devastating and potentially fatal cardiovascular event.

3 Feb 2012

Strong link between triglyceride levels and ischemic stroke in older women

In a surprising finding with significant implications for older women, researchers at Albert Einstein College of Medicine of Yeshiva University and NYU School of Medicine have found that high levels of triglycerides (blood fats) are the strongest risk factor for the most common type of stroke in older women – more of a risk factor than elevated levels of total cholesterol or of low-density lipoprotein (LDL) cholesterol.

3 Feb 2012

Multiple DNA repair defect in monocytes

Scientists working with Professor Bernd Kaina of the Institute of Toxicology at the Medical Center of Johannes Gutenberg University Mainz have demonstrated for the first time that certain cells circulating in human blood - so-called monocytes - are extremely sensitive to reactive oxygen species (ROS).

3 Feb 2012

Researcher have identified thirty one regions of genome associated with circulating metabolites

In a study to the genetic variance of human metabolism, researchers have identified thirty one regions of the genome that were associated with levels of circulating metabolites, i.e., small molecules that take part in various chemical reactions of human body.

30 Jan 2012

Study finds low blood levels of HDL in children with autism

Mystery surrounds autism. Its theories of causes and treatments are as unique and diverse as the people who have it. The same holds true for its symptoms. Scientists and physicians are uncovering more about this disorder every day; many of those studies and findings concentrate on diet.

25 Jan 2012

Study shows childhood experiences have long-term effects on health in midlife

Nurturing mothers have garnered accolades for rescuing skinned knees on the playground and coaxing their children to sleep with lullabies. Now they're gaining merit for their offspring's physical health in middle age.

24 Jan 2012

Viewpoints: The 'need' to repeal CLASS; Squaring Romney's poverty and tax promises

As a physician, I treated hundreds of patients who needed long-term care, including ones with Alzheimer's. More than 13.5 million seniors could have this disease by 2040. Middle-class families remain dangerously unprepared for these costs. Some people will likely spend more than $100,000 on care. The fictional CLASS daily benefit of $50 per day won't cover this. I urge my House and Senate colleagues to support this CLASS repeal.

19 Jan 2012

First study to elucidate how statins reduce activation of abnormal blood clotting

People with high cholesterol are at risk of heart attack and stroke because atherosclerotic plaques within their arteries can rupture triggering the formation of a blood clot called an occlusive thrombus that cuts off the blood supply to their heart or brain.

5 Jan 2012

Positive preliminary results from Alnylam's Phase I ALN-PCS trial on severe hypercholesterolemia

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the achievement of positive preliminary results from its ongoing clinical trial of ALN-PCS, an RNAi therapeutic targeting PCSK9 for the treatment of severe hypercholesterolemia.

5 Jan 2012

Adiponectin may play a role in development of all-cause dementia and AD in women

A hormone derived from visceral fat called adiponectin may play a role as a risk factor for development of all-cause dementia and Alzheimer disease (AD) in women, according to a study published Online First by the Archives of Neurology, one of the JAMA/Archives journals.

3 Jan 2012