Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
New method that detects NMD efficiency could help in treatment of many diseases

New method that detects NMD efficiency could help in treatment of many diseases

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Orphan Disease Center establishes new initiative that focuses on ALS

Orphan Disease Center establishes new initiative that focuses on ALS

New tool explains how proteins assemble into different liquid and gel-like solid states

New tool explains how proteins assemble into different liquid and gel-like solid states

Neuroscientists uncover how the brain retunes to pull meaning out of noisy environment

Neuroscientists uncover how the brain retunes to pull meaning out of noisy environment

Scientists identify naturally occurring molecule that plays protective role in ALS

Scientists identify naturally occurring molecule that plays protective role in ALS

Researchers identify mechanism of how circadian clocks in neurons encode daily rhythms of excitability

Researchers identify mechanism of how circadian clocks in neurons encode daily rhythms of excitability

New mouse models may open ways to develop therapies for ALS patients

New mouse models may open ways to develop therapies for ALS patients

Cognitive and physical fitness may have effects on risk of developing ALS

Cognitive and physical fitness may have effects on risk of developing ALS

Fruits, vegetables rich in antioxidants and carotenoids linked to better function in ALS patients

Fruits, vegetables rich in antioxidants and carotenoids linked to better function in ALS patients

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Study shows how damage to RNA-binding protein contributes to ALS

Study shows how damage to RNA-binding protein contributes to ALS

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

Abnormal protein in the brain may play important role in development of Alzheimer's disease

Abnormal protein in the brain may play important role in development of Alzheimer's disease

Scientists find way to reverse malfunctioning protein clumps involved in ALS

Scientists find way to reverse malfunctioning protein clumps involved in ALS

HMS study reveals key instigator of nerve cell damage in ALS patients

HMS study reveals key instigator of nerve cell damage in ALS patients