Low Density Lipoprotein (LDL) News and Research

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Study shows how two proteins provide a tunnel for bad cholesterol to enter the cells

A study has outlined how two proteins are instrumental to bringing cholesterol into cells – a finding that has implications for a range of diseases.

26 Jun 2020

Little-used measure of good cholesterol can predict heart attack and stroke risk

For decades, high-density lipoprotein (HDL) cholesterol has been dubbed "good cholesterol" because of its role in moving fats and other cholesterol molecules out of artery walls.

22 Jun 2020

Study reports structure of enzyme activator for high pathogenic avian influenza

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the current pandemic of COVID-19, is the focus of many investigators seeking to find an effective vaccine or therapeutic. Among the potential targets are various protease enzymes suspected of allowing the virus to gain entry to host cells and establish a successful infection.

16 Jun 2020

Potential new treatment approach to fatal COVID-19

Researchers from the University of Colorado Anschutz Medical Campus and Pathways Bioscience in the United States have found that activating a transcription factor involved in oxidative stress regulation, antiviral activity, and inflammation may serve as a new treatment approach to coronavirus disease 2019 (COVID-19).

18 May 2020

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol to near-normal levels among patients with a rare cholesterol disorder, meeting the primary endpoint in the first randomized placebo-controlled trial of the drug, which is being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

31 Mar 2020

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

The cholesterol drug alirocumab reduced low-density lipoprotein (LDL) cholesterol by 35.6% compared to placebo in adult patients with homozygous familial hypercholesterolemia (HoFH), according to a phase three clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Coconut oil increases bad cholesterol

Elevated low-density lipoprotein (LDL) or bad cholesterol level is an established risk factor for developing cardiovascular disease (CVD), including heart disease, hypertension, and stroke. Contrary to current claims that coconut oil can benefit cardiovascular health, a new study combining 16 published research shows that consumption of coconut oil is linked to higher levels of LDL and total cholesterol levels.

21 Jan 2020

NHS partners with pharma giant to trial a twice-a-year jab to lower cholesterol levels

Cardiovascular disease, including heart disease and stroke, are among the top killers worldwide. Ischemic heart disease and stroke are the world’s major killers, accounting for 15.2 million deaths in 2016. A high triglyceride level, combined with high low-density lipoprotein (LDL) cholesterol, is linked to atherosclerosis, which increases the risk for heart attack and stroke.

16 Jan 2020

Research funded by egg industry downplays the effect of cholesterol

Controversial headlines claiming that eggs don't raise cholesterol levels could be the product of faulty industry-funded research, according to a new review published in the American Journal of Lifestyle Medicine.

17 Dec 2019

Experimental drug found to be effective at reducing bad cholesterol

Twice-yearly injections of an experimental cholesterol-lowering drug, inclisiran, were effective at reducing low-density lipoprotein (LDL) cholesterol, often called bad cholesterol, in patients already taking the maximum dose of statin drugs, according to data of the ORION-10 trial presented Saturday, Nov. 16, at the American Heart Association's Scientific Sessions 2019.

17 Nov 2019

Eating one avocado a day associated with lower levels of LDL

Move over, apples -- new research from Penn State suggests that eating one avocado a day may help keep "bad cholesterol" at bay.

28 Oct 2019

Sustained drop in cholesterol and blood pressure reduces lifetime risk of heart, circulatory diseases

Modest and sustained decreases in blood pressure and cholesterol levels reduces the lifetime risk of developing fatal heart and circulatory diseases, such as heart attack and stroke, according to research part-funded by the British Heart Foundation and supported by the National Institute for Health Research.

4 Sep 2019

Care led by non-physician health workers more than doubled control of hypertension

Hypertension is the leading cause of cardiovascular disease worldwide, causing about 7.5 million deaths, approximately 12.8 percent of the total of all deaths. It is also a major risk factor for coronary artery disease and stroke.

3 Sep 2019

LDL cholesterol levels should be lowered as much as possible to prevent cardiovascular risk

Low-density lipoprotein cholesterol levels should be lowered as much as possible to prevent cardiovascular disease, especially in high and very high risk patients.

31 Aug 2019

Study finds much higher levels of ugly cholesterol in blood than earlier thought

The amount of remnant particle cholesterol in the blood, the so-called ugly cholesterol, is much higher than previously believed.

2 Aug 2019

Patients have higher risk of heart problems when insurance companies reject their prescriptions

Patients appear to be at higher risk of heart problems or stroke when prescriptions for the newest cholesterol-lowering drugs are rejected by insurance companies or unfilled by patients, according to new research in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

23 Jul 2019

Polygenic risk scores based on entire genome sequence may reliably predict heart disease

Specialized risk scores derived from testing that calculates the cumulative effect of an individual's entire DNA sequence, the genome, may reliably predict heart disease in people who have not yet had a heart attack, according to new research in Circulation: Genomic and Precision Medicine, an American Heart Association journal.

11 Jun 2019