Lung Vasculature News and Research

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Study reveals underlying signaling pathway that results in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a type of high blood pressure in the lungs, in which blood vessels are narrowed, blocked or destroyed, causing the heart to work harder and, in time, result in cardiac weakness and failure.

6 May 2022

Study shows BCG vaccine provides no protection against SARS-CoV-2 in mice and hamsters

Researchers investigated the effectiveness of the BCG vaccines against SARS-CoV-2 infections using three animal models.

23 Feb 2022

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Researchers in the UK and Germany have provided evidence for a novel mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – binds to human host cells.

27 Sep 2021

Researchers review the therapeutic potential of resveratrol nasal formulations in COVID-19

In a recently published article in the journal Frontiers in Immunology, scientists have reviewed the existing literature on antiviral and anti-inflammatory efficacy of resveratrol-based inhaled formulations in preventing SARS-CoV-2 infection and reducing COVID-19 severity.

9 Jun 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Kruppel-like factor 2 may be a major determinant of acute respiratory distress syndrome in COVID-19 patients

A study conducted at the University of Chicago, USA, has recently revealed that downregulation of an endothelial transcription factor, Kruppel-like factor 2, by SARS-CoV-2 is responsible for ARDS frequently observed in critically ill COVID-19 patients.

19 Jan 2021

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

The potentially deadly COVID-19 has not affected animals with corresponding severity. To understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new study indicates that this may not be a faithful model of human lethal infection with SARS-CoV-2.

18 Jan 2021

Microscopic revelations could lead to new treatment options for deadly blood infections

Researchers at the University of Calgary's Cumming School of Medicine (CSM) have for the first time been able to observe -- live and in real-time -- how the human body responds to often lethal fungal blood infections in the lung.

4 Apr 2018

Patrolling monocytes may play anti-cancer role in the lung

One goal of immunotherapy is to rally a patient's often over-burdened immune cells to effectively attack a tumor. Among foot soldiers on the immune front line is a subpopulation of white blood cells called "patrolling monocytes," whose job is to cruise the bloodstream, cart off cellular debris, and block invasion of a less benign population of inflammatory cells.

23 Oct 2015

Triciribine drug may reverse progression of pulmonary fibrosis and pulmonary hypertension

Researchers at the University of Georgia have discovered that the drug triciribine may reverse or halt the progression of pulmonary fibrosis and pulmonary hypertension, two respiratory diseases that are almost invariably fatal.

13 Jun 2015

New insight into how emphysema and COPD develop

By studying mice exposed to tobacco smoke for a period of months, researchers have new insight into how emphysema and chronic obstructive pulmonary disease (COPD) develop.

14 Oct 2011