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Personalized cancer vaccines can be used to marshal powerful immune response

Personalized cancer vaccines can be used to marshal powerful immune response

Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. [More]
Women face Lymphangioleiomyomatosis risk during their childbearing years

Women face Lymphangioleiomyomatosis risk during their childbearing years

A rare and potentially deadly lung disease called Lymphangioleiomyomatosis (LAM) strikes women during their childbearing years. [More]
New approach to treating B-ALL tumour disease

New approach to treating B-ALL tumour disease

B cell acute lymphoblastic leukaemia, or B-ALL, is the most common tumour disease in children and also occurs in adults. It develops when signalling pathways in immature B cells, or pre-B cells, are dysregulated. Prof. Dr. Markus Müschen from the University of California in San Francisco, USA, and his team worked together with the BIOSS researchers Prof. Dr. Hassan Jumaa and Prof. Dr. Michael Reth to find a new approach for treating the B-ALL tumour disease. [More]
Researchers find way to enhance effects of immunotherapy in glioblastoma

Researchers find way to enhance effects of immunotherapy in glioblastoma

When cancer strikes, it may be possible for patients to fight back with their own defenses, using a strategy known as immunotherapy. According to a new study published in Nature, researchers have found a way to enhance the effects of this therapeutic approach in glioblastoma, a deadly type of brain cancer, and possibly improve patient outcomes. [More]
Tetanus booster shot enhances effect of vaccine therapy for lethal brain tumors

Tetanus booster shot enhances effect of vaccine therapy for lethal brain tumors

An innovative approach using a tetanus booster to prime the immune system enhances the effect of a vaccine therapy for lethal brain tumors, dramatically improving patient survival, according to a study led by Duke Cancer Institute researchers. [More]
Oncologists welcome gene expression profiling tests for women with early-stage breast cancer but have concerns

Oncologists welcome gene expression profiling tests for women with early-stage breast cancer but have concerns

Oncologists welcome gene expression profiling tests as an added tool in deciding whether women with early-stage breast cancer should have chemotherapy, a new study has found. But they have significant reservations about the cost of the test and whether it is being overused and used for the right patients. [More]
Breast cancer survivors at increased risk of developing thyroid cancer, finds new study

Breast cancer survivors at increased risk of developing thyroid cancer, finds new study

Breast cancer survivors are at increased risk of developing thyroid cancer, especially within five years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego. [More]
Single-site laparoscopic surgery effective for colorectal cancer

Single-site laparoscopic surgery effective for colorectal cancer

Colorectal cancer may be highly preventable, yet it is second only to lung cancer in the number of lives it takes nationwide each year. [More]
Patients who undergo chemo before breast cancer operation more likely to opt for lumpectomy

Patients who undergo chemo before breast cancer operation more likely to opt for lumpectomy

Patients with larger malignant tumors of the breast who undergo chemotherapy before a breast cancer operation are more likely to opt for a breast-preserving procedure and forgo a mastectomy (surgical removal of the breast), according to a new study published online as an "article in press" in the Journal of the American College of Surgeons. [More]
Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Findings from a federally funded study suggest that patients with locally advanced kidney cancer should not be treated with either adjuvant (post-surgery) sorafenib or sunitinib. The average period to disease recurrence was similar between those who received sorafenib or sunitinib after surgery (5.6 years) and those treated with placebo (5.7 years). [More]
Discovery offers much needed information about how virulent insect-borne diseases cause infection

Discovery offers much needed information about how virulent insect-borne diseases cause infection

For decades, scientists have thought the bacteria that cause the bubonic plague hijack host cells at the site of a fleabite and are then taken to the lymph nodes, where the bacteria multiply and trigger severe disease. But UNC School of Medicine researchers discovered that this accepted theory is off base. The bacteria do not use host cells; they traffic to lymph nodes on their own and not in great numbers. [More]
Research provides new insights into rapid defence responses in human immune system

Research provides new insights into rapid defence responses in human immune system

Researchers have uncovered a sieve-like structure in lymph nodes that regulates the transport of proteins and migration of white blood cells into lymph nodes. [More]
Diabetes medication can help white blood cells fight bacterial infections

Diabetes medication can help white blood cells fight bacterial infections

Pioglitazone, a medication approved for treatment of type 2 diabetes, can help bypass genetic defects in chronic granulomatous disease to help white blood cells fight bacterial infections, according to researchers at National Jewish Health. [More]
FDA advisory committees to review Amgen's talimogene laherparepvec for metastatic melanoma treatment

FDA advisory committees to review Amgen's talimogene laherparepvec for metastatic melanoma treatment

Amgen announced today that the Cellular, Tissue and Gene Therapies Advisory Committee and the Oncologic Drugs Advisory Committee of the U.S. Food and Drug Administration will jointly review the Company's Biologics License Application (BLA) for talimogene laherparepvec. [More]
Discovery provides new insights into rapid defence responses in the immune system

Discovery provides new insights into rapid defence responses in the immune system

Researchers have uncovered a sieve-like structure in lymph nodes that regulates the transport of proteins and migration of white blood cells into lymph nodes. The discovery, made by scientists working at the University of Turku, Finland, will provide new insights into rapid defence responses in the human immune system. The research was carried out with funding from the Academy of Finland and the Sigrid Juselius Foundation. [More]
Only 65% of breast cancer patients who undergo mastectomy receive postmastectomy radiation therapy

Only 65% of breast cancer patients who undergo mastectomy receive postmastectomy radiation therapy

Breast cancer patients who undergo a mastectomy should receive subsequent radiation treatment if their cancer has spread to four or more nearby lymph nodes, however, according to a new study, only 65 percent of these women are getting the recommended postmastectomy radiation therapy (PMRT). [More]
Research finding could help predict the next outbreak of plague

Research finding could help predict the next outbreak of plague

Biologists at the University of Oslo, Norway, are now making a giant effort to identify the relationship between climate change, rat infestations, and the many major plague epidemics throughout history. The knowledge may be used to predict the next plague outbreak. [More]
CLL aggressiveness linked to genetic variability

CLL aggressiveness linked to genetic variability

The genetic variability of a tumour could be a predictor for its aggressiveness: the greater the variability in gene expression, the more aggressive the tumour is likely to be. This is the hypothesis that the CNIO Structural Biology and Biocomputing Programme, led by Alfonso Valencia, is testing, after their findings on chronic lymphocytic leukaemia (CLL), now published in the journal Genome Medicine. [More]
Ultrasound narrows which breast cancer patients need underarm lymph nodes removed

Ultrasound narrows which breast cancer patients need underarm lymph nodes removed

Which breast cancer patients need to have underarm lymph nodes removed? Mayo Clinic-led research is narrowing it down. A new study finds that not all women with lymph node-positive breast cancer treated with chemotherapy before surgery need to have all of their underarm nodes taken out. [More]
New study helps explain how booster shots trigger immune 'memory' to improve

New study helps explain how booster shots trigger immune 'memory' to improve

The last time you were in the doctor's office for a vaccine booster shot, did you wonder why you needed one? Exactly how booster shots offer long-term protection from viruses has long been a mystery to scientists. [More]
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