Lymphadenopathy News and Research

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Lymphadenopathy refers to the enlargement of one or more lymph nodes, the bean-shaped glands found in the neck, armpits, chest, groin, and abdomen. Lymphadenopathy may occur in just one part of the body, in which case it is referred to as “localized” or it may be present in two or more body areas, in which case it is referred to as “generalized.” The condition most commonly affects nodes in the neck (cervical lymph nodes).

Case study: Monkeypox breakthrough infection in fully vaccinated individual

New research to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases in Barcelona, Spain (27-30 April) details the case of a man who had received two doses of the monkey pox vaccine in Autumn, 2022 yet experienced a 'breakthrough' mpox infection in January 2024.

1 Apr 2024

New insights into the exacerbation of psoriasis through specific genetic defects

The inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.

27 Mar 2024

Novavax's protein-based COVID vaccine induces broad functional immune response against XBB subvariants, data shows

Novavax, Inc., a global company advancing protein-based vaccines with its novel Matrix-M™ adjuvant, today announced that its updated protein-based XBB COVID vaccine candidate induced neutralizing antibody responses to the EG.5.1 and XBB.1.16.6 subvariants in small animal and non-human primate studies.

25 Aug 2023

HIV status does not affect Tecovirimat treatment outcomes for Mpox virus infection

A retrospective cohort study comparing the clinical presentation and treatment outcomes of people with HIV and those without HIV who were treated with tecovirimat for confirmed mpox virus infection. The study found that HIV status did not seem to affect treatment outcomes.

4 May 2023

Study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation

A newly published study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation.

30 Mar 2023

Study details bacterial agents in 418 ticks extracted from humans in France

In a recent study published in the journal Emerging Infectious Diseases, researchers analyzed ticks that bit humans between January 2014 and March 2021 in France for the presence of bacterial pathogens.

27 Mar 2023

CDC recommendations and clinical considerations for the treatment of severe Mpox

In a recent article published in the United States (U.S.) Centers for Disease Control and Prevention's (CDC) Morbidity and Mortality Weekly Report, a team of researchers discussed the medical countermeasures and clinical considerations for treating severe manifestations of Mpox.

6 Mar 2023

The effectiveness of respiratory interventions and case isolation measures in reducing or preventing the transmission of mpox in humans

Researchers conducted a systematic review to evaluate the effectiveness of case isolation and respiratory interventions in limiting the transmission of mpox in humans.

20 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Underlying genetic cause for MIS-C complications after COVID-19 identified

A recent Science journal study determined the underlying cause of MIS-C related to SARS-CoV-2 in some children. It hypothesized that monogenic inborn errors of immunity (IEI) is the primary reason for this condition. Identifying these inborn errors is expected to help elucidate the disease's cellular, molecular, and immunological basis.

2 Jan 2023

What are the characteristics of misdiagnosed human mpox cases?

In a recent study, researchers characterized overlooked cases of monkeypox (MPX).

21 Dec 2022

The mpox viral load kinetics over time in various parts of the body

Researchers characterized the time to mpox virus clearance of immunocompetent individuals with mild MPX in a real-world community-based setting utilizing longitudinal information.

16 Dec 2022

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers validated monkeypox virus (MPXV) quantitative polymerase chain reaction (qPCR) assays.

17 Nov 2022

What are the eye complications associated with monkeypox infection?

A new study describes the association between monkeypox infection and eye complications in humans.

9 Nov 2022

Monkeypox: Painful, itchy skin lesions localized in the genital region

In the setting of the current monkeypox outbreak it is important to consider different clinical courses. This includes skin changes/lesions that are primarily localized at the presumed inoculation sites, a low exanthematous component, and onset of general symptoms only over the course if the illness.

4 Nov 2022

Study explores the stability of monkeypox viral DNA in various body fluid samples

Researchers used laboratory diagnostic testing data of monkeypox cases and performed. They performed mathematical modeling to predict how long monkeypox viral deoxyribonucleic acid (DNA) remains detectable in different body fluid samples.

24 Oct 2022

Review of characteristics of human monkeypox

Researchers conducted a scoping review of available literature on monkeypox (MPX), in a new study.

20 Oct 2022

Bioinformatics analysis of monkeypox virus-host cell interactions

A recent study posted to the bioRxiv* preprint server reported the interaction between monkeypox and human cells. Molecular sequences were screened to identify differentially expressed genes (DEGs) and their associated signal pathway, expression regulation, and metabolic pathways.

18 Oct 2022

What is the impact of monkeypox infection on the hemostatic system?

In a recent study, researchers determined if monkeypox (MPX) infection affected the hemostatic system like that observed in coronavirus disease 2019 (COVID-19).

6 Oct 2022