Lymphangioleiomyomatosis News and Research

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UC researchers discover treatment for a rare cancer-like lung disease in women

A treatment for a rare cancer-like lung disease found in women of childbearing age may have been discovered by University of Cincinnati researchers.

15 Jun 2023

Tiny lipid-based nanoparticles carry genetic instructions directly into the lungs

Researchers at the Tufts University School of Engineering are building a reputation for precision targeting in drug delivery.

23 Feb 2022

Scientists discover new insights about lymphangioleiomyomatosis

Researchers have discovered new insights about lymphangioleiomyomatosis (LAM), a rare lung disease, which affects about 1 in 200,00 Americans and commonly features the growth of abnormal cells in different tissues and organs, including the lungs.

1 Feb 2022

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

AI Therapeutics is a clinical-stage biopharmaceutical company that has created an artificial intelligence-driven drug development platform for matching drugs to new indications.

7 Jan 2020

FDA-approved drug to prevent organ rejection may slow skin aging

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray.

25 Nov 2019

Low-magnetic field MRI produces clearer images and improves safety for patients with pacemakers

Researchers have developed a high-performance, low magnetic-field MRI system that produces superior images of the body’s internal structures and is also safer.

4 Oct 2019

Novel 3D hydrogel helps researchers to quickly screen potential cancer drugs

A 3D hydrogel created by researchers in U of T Engineering Professor Molly Shoichet's lab is helping University of Ottawa researchers to quickly screen hundreds of potential drugs for their ability to fight highly invasive cancers.

26 Feb 2019

ATS and JRS publish new guidelines for diagnosis and management of LAM

The American Thoracic Society and the Japanese Respiratory Society have published additional clinical practice guidelines regarding four specific questions related to the diagnosis of lymphangioleiomyomatosis (LAM) and management of pneumothoraces in patients with LAM.

15 Nov 2017

New clinical trial examines potential role of drug combination therapy to eliminate LAM cells

Researchers at the University of Cincinnati begin a new clinical trial this fall, examining the potential role of a drug combination therapy to eliminate lymphangioleiomyomatosis (LAM) cells.

7 Aug 2017

UC scientists take different approach to investigating how influenza spreads through the lungs

Influenza is a recurring global health threat that, according to the World Health Organization, is responsible for as many as 500,000 deaths every year, most due to influenza pneumonia, or viral pneumonia.

25 Jul 2017

Study links heart failure biomarker to tumors observed in rare genetic diseases

Galectin-3, a protein that promotes cancer cell growth and is used as a biomarker for heart failure, has been linked to tumors observed in two rare genetic diseases, according to a study published July 11, 2017, in eLife.

11 Jul 2017

ATS releases new clinical practice guidelines for diagnosis, management of LAM

The American Thoracic Society and the Japanese Respiratory Society have published new clinical practice guidelines for the diagnosis and management of lymphangioleiomyomatosis (LAM), a rare lung disease that primarily affects women of child-bearing age.

15 Sep 2016

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies.

8 Jun 2016

Hermansky-Pudlak syndrome can cause debilitating lung disease in Puerto Ricans

A hereditary condition called Hermansky-Pudlak syndrome (HPS) can cause bleeding problems, low vision, albinism and, in some patients, a debilitating lung disease.

21 Sep 2015

Women face Lymphangioleiomyomatosis risk during their childbearing years

A rare and potentially deadly lung disease called Lymphangioleiomyomatosis (LAM) strikes women during their childbearing years.

29 Mar 2015

Innovative treatment option for children with plastic bronchitis

A case study published recently in the journal Pediatrics describes an innovative, minimally invasive procedure that treated plastic bronchitis, a potentially life-threatening disease, in a six-year-old boy with a heart condition. Using new lymphatic imaging tools and catheterization techniques, physician-researchers eliminated bronchial casts, which are an accumulation of lymphatic material that clogged the child's airway.

22 Oct 2014

Docs who treat patients with severe LAM face agonizing treatment decision

Doctors who treat patients with a severe and progressive respiratory disease called lymphangioleiomyomatosis (LAM) can face an agonizing treatment decision.

18 Apr 2014

NIH awards $12.7M to research groups to explore new treatments for patients in eight disease areas

The National Institutes of Health has awarded $12.7 million to match nine academic research groups with a selection of pharmaceutical industry compounds to explore new treatments for patients in eight disease areas, including Alzheimer's disease, Duchenne muscular dystrophy and schizophrenia.

19 Jun 2013

Researchers discover how drug prevents cancer progression

In collaboration with Daniel Zenklusen, also a University of Montreal biochemistry professor and lead author and doctoral candidate Vincent Messier, discovered that when cells are starved for nutrients TOR sends a signal to shut down production of a chemical message in the form of RNA to synthesize B cyclin ", Dr. Michnick explained.

24 May 2013

Tuberous sclerosis complex lesions respond well to everolimus in EXIST

Results from two phase III trials demonstrate significantly better skin lesion reduction with everolimus than placebo in patients with tuberous sclerosis complex.

3 Oct 2012