Lynch Syndrome News and Research

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Urothelial cancers in Lynch Syndrome patients can be detected using a simple, cheap urine test

Researchers have shown for the first time that it is possible to detect signs of urothelial cancer using a simple, postal, urine test in Lynch Syndrome (LS) patients who are at high risk of developing tumors.

11 Nov 2021

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

A new strategy for developing vaccines against cancer showed promise in a proof-of-concept study led by scientists at Weill Cornell Medicine, NewYork-Presbyterian and Heidelberg University Hospital.

2 Aug 2021

New study to test the scalability of offering preventive DNA screening to young adults for cancer risk

A landmark new DNA screening study to identify cancer risk in young adults will go ahead, after Monash University researcher Associate Professor Paul Lacaze was awarded a $2.97 million Medical Research Future Fund (MRFF) grant today.

2 Jul 2021

Should colorectal cancer screening start at age 45?

Colorectal cancer rates among young adults are steadily increasing over the years. The United States Task Force has long recommended that people aged 50 to 75 get screened. Now, the U.S. Preventive Services Task Force updated its 2016 recommendation of colorectal screening for people aged 50, down to 45 years old. The five-year earlier screening can save many lives by allowing earlier diagnosis and treatment of the condition.

21 May 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome

The researcher Gabriela Debesa, member of the research group at Simbiosis led by Andrés Moya at the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (Fisabio), studied the relationship of the intestinal microbiota with colon cancer in patients with Lynch Syndrome (a hereditary illness that predisposes the development of cancer) using tissue samples in formalin and conserved in paraffin.

6 Apr 2021

Study outlines the reasons to test pediatric cancer patients for inherited genes

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

16 Feb 2021

Gene screenings hold disease clues, but unexplained anomalies often raise fears

When her gynecologist recommended genetic testing, Mai Tran was reluctant.

9 Feb 2021

New method identifies important mutations behind hereditary non-polyposis colorectal cancer

Colorectal cancer is the third most common form of cancer. While 90% of cases are in people older than 50, there is an as-yet unexplained rising incidence in younger people.

29 Jan 2021

Study shows lack knowledge about colonoscopy among high-risk patients

Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor.

14 Sep 2020

Study shows why certain genetically predisposed individuals do not develop heart disease

Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can lead to elevated cholesterol and increased risk for a premature heart attack.

20 Aug 2020

Population screening has potential to identify individuals at risk for inherited genetic conditions

In a new study published today in the journal Nature Medicine, researchers behind the Healthy Nevada Project® suggest that community-based genetic screening has the potential to efficiently identify individuals who may be at increased risk for three common inherited genetic conditions known to cause several forms of cancer and increased risk for heart disease or stroke.

27 Jul 2020

Aspirin reduces hereditary colorectal cancer risk

Aspirin reduces colorectal cancer risk by half in individuals at high genetic risk. Preventive efficacy is prolonged for 10-20 years after treatment with aspirin.

11 Jun 2020

Promega announces CE marking for OncoMate MSI Dx Analysis System in Europe

Promega Corporation today announced CE marking for the OncoMate MSI Dx Analysis System as a new in vitro diagnostic medical device in Europe.

From Promega Corporation 10 Jun 2020

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy.

30 May 2020

Indiana researchers identify new target for colorectal cancer immunotherapy

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.

11 May 2020

Individuals with high risk of cancer and CVD cannot be identified based on family history

Certain genetic changes, termed "pathogenic variants," substantially increase risk for cardiovascular disease and cancer--the leading causes of death--but testing to identify individual carriers is not part of current clinical practice.

4 May 2020

Increased risk of uterine cancer linked to 24 gene variants

The risk of uterine endometrial cancer is increased by 24 gene variants that code for different cellular processes such as cell growth and death, gene regulation, and estrogen metabolism, according to a comprehensive review published in the Journal of Medical Genetics.

17 Feb 2020

Study provides new details about therapy-associated polyposis in childhood cancer survivors

In a paper published online today, Dana-Farber Cancer Institute researchers provide new details about a recently discovered condition in which childhood cancer survivors develop numerous colorectal growths called polyps despite not having a hereditary susceptibility to the condition.

12 Feb 2020

Determining Microsatellite Instability Status Using Multiplex PCR-Based Methods

Determining microsatellite instability status using multiplex PCR-based methods used to screen for Lynch Syndrome, a dominant hereditary cancer propensity.

From Promega Corporation 24 Jan 2020