Lysosomes News and Research

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Universities collaborate on $15 million project investigating inflammation's role in cardiac and brain diseases

Research teams from Northwestern University Chicago Campus, University of Michigan and University of Pittsburgh will lead a $15 million project dedicated to studying inflammation's role in cardiac and brain diseases.

17 Apr 2024

Researchers identify a novel mechanism connected to the early stages of Alzheimer's disease

Alzheimer's disease (AD) remains one of the most challenging and prevalent neurodegenerative disorders, affecting millions of individuals worldwide.

15 Apr 2024

Novel signaling pathway identified in lysosome damage response

Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm.

8 Apr 2024

Rare variants in the YKT6 gene cause new neurological disorder, study finds

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

1 Apr 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Discovery of new organelle could improve the understanding of chronic liver diseases

Scientists have identified a new organelle in liver cells called the mitochondria-lysosome-related organelle (MLRO).

12 Mar 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.

4 Jan 2024

A protein identified as key player in keeping cells tidy

Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell.

2 Jan 2024

Shedding new light on the hidden organization of the cytoplasm

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

21 Dec 2023

Clearing the cellular clutter: New insights into how our cells stay healthy

If we don't take out the trash regularly, our homes become unpleasant and even a danger to our health.

20 Dec 2023

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

Study suggests iron accumulation plays a central role in senescence and fibrosis

Researchers investigated the association between cellular damage, iron buildup, senescence, and fibrosis.

18 Dec 2023

D-mannose could improve age-associated urinary tract dysfunction and help reduce UTIs

Aging poses a number of challenges to the body's well-being, one of the most important being an increased susceptibility to multiple diseases, including urinary tract infections (UTIs).

14 Dec 2023

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

4 Dec 2023

Unveiling the role of Daam1 gene in intestinal stem cell fate decisions

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation?

24 Nov 2023

Microautophagy plays crucial role in lysosome repair, promoting healthy aging

To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes-;critically important cellular structures-;are crucial for digesting damaged cellular components and pathogens, and maintain stability within cells and tissues.

21 Nov 2023

Study links nanoplastics to Parkinson's disease and dementia

Nanoplastics interact with a particular protein that is naturally found in the brain, creating changes linked to Parkinson's disease and some types of dementia.

17 Nov 2023

Stanford chemists uncover new pathway for protein degradation, opening door to new therapeutics

When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein's active site so it can't function and wreak havoc.

25 Oct 2023

Oral pathogen linked to increased risk of heart rupture after heart attack

Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction.

19 Oct 2023

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression.

12 Oct 2023