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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular "off" switch for the inflammatory immune response that contributes to lung-constricting asthma attacks. [More]
Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors' recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered. [More]
Würzburg researchers develop novel technique to provide new insight into Salmonella infection process

Würzburg researchers develop novel technique to provide new insight into Salmonella infection process

Technological advances are making the analysis of single bacterial infected human cells feasible, Würzburg researchers have used this technology to provide new insight into the Salmonella infection process. [More]
Getting drugs to bugs in NTM lung infections: an interview with Dr Jakko van Ingen

Getting drugs to bugs in NTM lung infections: an interview with Dr Jakko van Ingen

The first thing that is important to stress is that this is an area that we actually know very little about. What we generally think, rather than know, is that NTM has a lot in common with pulmonary tuberculosis. [More]
UAB researchers show how aging and excess dietary fat lead to heart failure

UAB researchers show how aging and excess dietary fat lead to heart failure

In mouse experiments, University of Alabama at Birmingham researchers have shown how aging and excess dietary fat create signals that lead to heart failure after a heart attack. [More]
Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Researchers from the San Francisco Veterans Affairs Medical Center and UCSF, and CalciMedica, Inc., are presenting a poster at the 46th annual Society for Neuroscience meeting in San Diego describing the use of calcium release-activated calcium (CRAC) channel inhibitors in traumatic brain injury (TBI). [More]
TSRI study suggests new approach to limit tumor growth by targeting immune system cells

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

A new study led by scientists at The Scripps Research Institute suggests there may be a way to limit tumor growth by targeting immune system cells called macrophages. [More]
Immune checkpoint cancer therapies may cause rare cardiac side effects linked to unexpected immune response

Immune checkpoint cancer therapies may cause rare cardiac side effects linked to unexpected immune response

Combination therapy utilizing two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. [More]
Research shows way to directly target genes within specific cell type

Research shows way to directly target genes within specific cell type

The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or otherwise destroy gene X in that tissue and then watch what happens. [More]
Researchers identify two new potential drug targets for treating atherosclerosis

Researchers identify two new potential drug targets for treating atherosclerosis

Researchers at Brigham and Women's Hospital have found two new potential drug targets for treating arterial diseases such as atherosclerosis. [More]
Optical and PET/CT activity-based probes could help in non-invasive imaging of atherosclerotic plaques

Optical and PET/CT activity-based probes could help in non-invasive imaging of atherosclerotic plaques

Researchers at Stanford University have demonstrated for the first time the use of a dual optical and PET/CT activity-based probe to detect atherosclerotic plaques. The study is published in the October issue of the Journal of Nuclear Medicine. [More]
Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Research from Kumamoto University, Japan has found that a natural compound isolated from onions, onionin A (ONA), has several anti-ovarian cancer properties. [More]
Finnish researchers identify molecular mechanism that controls migration of early macrophages

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults. [More]
UT Southwestern researchers discover protein that leads to brain cell death during stroke

UT Southwestern researchers discover protein that leads to brain cell death during stroke

One particular protein is the final executioner of events that result in the death of brain cells during stroke, researchers from UT Southwestern Medical Center and their collaborators report. This finding could ultimately lead to new ways to protect against brain damage. [More]
Added benefit not proven for melanoma drug, IQWiG finds

Added benefit not proven for melanoma drug, IQWiG finds

Talimogene laherparepvec has been approved since December 2015 for adults with advanced melanoma. [More]
Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's. [More]
BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

Researchers from Ben-Gurion University of the Negev have published a new study that describes a novel molecular mechanism that could lead to the development of new therapies for Amyotrophic Lateral Sclerosis (ALS). [More]
Researchers identify new immune cell that protects mice from lung infections during chemotherapy

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy. [More]
Novartis gets three FDA approvals for expanded use of biologic drug to treat rare autoinflammatory diseases

Novartis gets three FDA approvals for expanded use of biologic drug to treat rare autoinflammatory diseases

Novartis announced today that the US Food and Drug Administration has granted three simultaneous approvals for the expanded use of Ilaris (canakinumab) to treat three rare and distinct types of Periodic Fever Syndromes. [More]
Breakthrough research opens door to potential new therapies for inflammatory diseases

Breakthrough research opens door to potential new therapies for inflammatory diseases

Scientists have made a major breakthrough in understanding the workings of the cellular machinery involved in a host of inflammatory diseases. [More]
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