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Exposure to titanium dioxide nanoparticles increases bacterial infection of HeLa cells

Exposure to titanium dioxide nanoparticles increases bacterial infection of HeLa cells

When human cells are exposed to titanium dioxide without the presence of UV light from the sun, the risk for bacterial infection more than doubles. This finding by a Stony Brook University-led research team, published early online in the Journal of Nanobiotechnology, raises concerns about exposure to titanium dioxide, a nanoparticle commonly used in millions of products worldwide ranging from cosmetics to toothpaste, gum, food coloring, and medicines. [More]
Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature. [More]
Macrophages play key role in quick tissue repair

Macrophages play key role in quick tissue repair

While scientists have known for many years that there are cells living in the cavities surrounding various organs such as the heart, lung and liver, their function has remained unknown. A recent Cumming School of Medicine study examined these cells, and discovered they play an integral role in fast tissue repair. The study was published in the journal Cell this month. [More]
LAP defects may lead to lupus-like autoimmune disorder

LAP defects may lead to lupus-like autoimmune disorder

A casual observation about size differences in mice has led to the discovery that defects in a process for digesting dead cells called LC3-associated phagocytosis (LAP) may lead to a lupus-like autoimmune disorder. St. Jude Children's Research Hospital scientists led the research, which appears as an advance online publication today in the scientific journal Nature. [More]
Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers from VIB-UGent reveal that adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and self-maintenance capacities as macrophages of embryonic origin. [More]
Study shows beneficial effect of hNSC transplantation for TBI

Study shows beneficial effect of hNSC transplantation for TBI

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. Treatment is limited to supportive care, but stem cell therapy has received recent attention as a way to promote recovery for injuries to the central nervous system (CNS). In this study, researchers transplanted human neural stem cells (hNSCs) into the brains of mice modeled with TBI to investigate whether the hosts' immune systems and the stem cells acting in concert would enhance repair. [More]
Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

Putting just a tiny piece of the wall of detoxified E. coli into their gut make mice lose their natural sweet tooth, researchers report. [More]
Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology. [More]
Study describes precise mechanisms that enable TB bacteria to persist in the body

Study describes precise mechanisms that enable TB bacteria to persist in the body

Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and published online April 18 in Nature Immunology. [More]
Cyclodextrin offers potential new therapy for cardiovascular disease

Cyclodextrin offers potential new therapy for cardiovascular disease

An American mother's hunch might result in new treatments for patients who can't tolerate conventional cholesterol-lowering drugs. [More]
Therapies based on alpha defensins could help treat rheumatoid arthritis

Therapies based on alpha defensins could help treat rheumatoid arthritis

Arthritis and other inflammatory conditions could be helped by new insights into how the immune response is switched off. [More]
Inflammation after stroke may help the brain to self-repair

Inflammation after stroke may help the brain to self-repair

After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair. [More]
Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cardiovascular disease from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are considered to be early triggers in the development of the disease. [More]
Bacteria uses sensitive, nano-sized pump to transport magnesium

Bacteria uses sensitive, nano-sized pump to transport magnesium

Researchers at UiO and NCMM have discovered that the system used by bacteria to transport magnesium is so sensitive that it can detect a pinch of magnesium salt in a swimming pool. [More]
Salk scientists identify specific cellular switches that clear dying, dead neurons

Salk scientists identify specific cellular switches that clear dying, dead neurons

By adolescence, your brain already contains most of the neurons that you'll have for the rest of your life. But a few regions continue to grow new nerve cells--and require the services of cellular sentinels, specialized immune cells that keep the brain safe by getting rid of dead or dysfunctional cells. [More]
Innovative nano-therapy treatment can fight chronic inflammatory disorders, cancer

Innovative nano-therapy treatment can fight chronic inflammatory disorders, cancer

For an innovative treatment, which allows to selectively direct nanoparticles of iron oxide into cell targets in the blood to fight chronic inflammatory disorders or cancer that was successfully tested in a cell culture and animal models, Dr. Andrea de Vizcaya Ruiz, was awarded with the Innovation Award in Bionanotechnology Cinvestav-Neolpharma 2015. [More]
End-stage heart failure patients treated with cell therapy experience fewer cardiac events

End-stage heart failure patients treated with cell therapy experience fewer cardiac events

End-stage heart failure patients treated with stem cells harvested from their own bone marrow experienced 37 percent fewer cardiac events - including deaths and heart failure hospital admissions - than a placebo-controlled group, according to a new study. [More]
Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

In obesity, the body's immune system can treat tissues as if they are suffering from a low-grade chronic infection. This obesity-induced inflammation is an important contributor to insulin resistance, a condition that can progress into type 2 diabetes. [More]
New drug regimens could significantly improve treatment for tuberculosis

New drug regimens could significantly improve treatment for tuberculosis

Researchers from UCLA and Shanghai Jiao Tong University have made an important step toward a substantially faster and more effective treatment for tuberculosis, which infects some 10 million people and causes 1.5 million deaths each year. [More]
Innovative ultrasound method can help determine risk of strokes, heart attacks

Innovative ultrasound method can help determine risk of strokes, heart attacks

Researchers at Lund University in Sweden have discovered a new and more accurate way to distinguish between harmful and harmless plaque in the blood vessels by using ultrasound. This can help healthcare providers determine the risk of strokes and heart attacks - which means avoiding unnecessary surgery for many patients. [More]
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