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2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

A first-ever interlaboratory study of four versions of a therapeutic protein drug—all manufactured from living cells—reports that an established analytical tool akin to magnetic resonance imaging reliably assessed the atomic structures of the biologically similar products, yielding the equivalent of a fingerprint for each. [More]
UC San Diego School of Medicine launches new NAFLD Research Center

UC San Diego School of Medicine launches new NAFLD Research Center

Roughly one-quarter of all Americans - an estimated 100 million adults and children - have nonalcoholic fatty liver disease (NAFLD), a chronic condition that can lead to cirrhosis, liver cancer and liver failure. [More]
Vienna researchers investigate new light therapy treatment for people with migraines

Vienna researchers investigate new light therapy treatment for people with migraines

Migraines often involve heightened sensitivity to light. In a project funded by the Austrian Science Fund FWF, a team of researchers from the Medical University of Vienna is investigating new therapies to treat light sensitivity, which greatly disturbs those affected. [More]
Aging brains work differently than younger brains, say cognitive scientists

Aging brains work differently than younger brains, say cognitive scientists

Cognitive scientists have found more evidence that aging brains work differently than younger brains when performing the same memory task, pointing to a potentially new direction for age-related cognitive care and exploration. [More]
Noninvasive FMRI may help evaluate effectiveness of new pain medications

Noninvasive FMRI may help evaluate effectiveness of new pain medications

New research may allow new, more effective and safer pain medications to reach patients who suffer from chronic pain sooner. According to a recent study published in Anesthesiology, the official medical journal of the American Society of Anesthesiologists, using functional magnetic resonance imaging (FMRI), to measure the brain's neural response to pain, may be a viable tool for evaluating the effectiveness of new pain medications during the early stages of human drug development - providing the needed objective evidence to prevent the premature discarding of potentially beneficial therapies. [More]
Natalizumab shows relapse prevention benefits over fingolimod in MS

Natalizumab shows relapse prevention benefits over fingolimod in MS

Natalizumab may be superior to fingolimod for preventing relapses during the first year of treatment in patients with relapsing–remitting multiple sclerosis, observational study findings show. [More]
Diffusion tensor imaging ‘should be routine’ in SVD assessment

Diffusion tensor imaging ‘should be routine’ in SVD assessment

Gait speed and microstructural brain damage may be the best indicators of mortality risk in patients with small vessel disease, say researchers. [More]
Combined MRI and ultramicroscopy toolkit could help study vessel growth in glioma models in more detail

Combined MRI and ultramicroscopy toolkit could help study vessel growth in glioma models in more detail

Stopping the growth of blood vessels in tumours is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. While mapping vessels in tumours has proven a challenge, researchers have now developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible. [More]
New analysis method may help categorise stroke patients with language problem

New analysis method may help categorise stroke patients with language problem

Brain researcher Karsten Specht has found a new method of analysis to distinguish between stroke patients with language problem. The result may be individualised treatment for each patient. [More]
Researchers link symptoms of schizophrenia with the brain's anatomical characteristics

Researchers link symptoms of schizophrenia with the brain's anatomical characteristics

An international team, made up of researchers from the University of Granada, Washington University in St. Louis, and the University of South Florida, has linked the symptoms of schizophrenia with the anatomical characteristics of the brain, by employing magnetic resonance imaging (MRI). [More]
MRI safe for patients with implantable cardiac devices

MRI safe for patients with implantable cardiac devices

The findings of a major study led by cardiovascular imaging specialists at Allegheny General Hospital, part of the Allegheny Health Network, suggest that magnetic resonance imaging is a safe and effective diagnostic procedure for patients with implantable cardiac devices. [More]
Men with ASD have differences in brain connections

Men with ASD have differences in brain connections

Research at King's College London has revealed subtle brain differences in adult males with autism spectrum disorder (ASD), which may go some way towards explaining why symptoms persist into adulthood in some people with the disorder. [More]
Fingolimod trial INFORMS primary progressive MS strategy

Fingolimod trial INFORMS primary progressive MS strategy

Fingolimod is unable to slow disability progression or brain volume loss in patients with primary progressive multiple sclerosis, show the findings of the INFORMS study. [More]
New technique may reduce need for amputation in patients with critical limb ischemia

New technique may reduce need for amputation in patients with critical limb ischemia

A new imaging technique could reduce the need for amputation in patients with critical limb ischemia, according to a study publised today in the scientific journal JACC. [More]
New brain imaging technique may help identify children at risk of developing depression

New brain imaging technique may help identify children at risk of developing depression

A new brain imaging study from MIT and Harvard Medical School may lead to a screen that could identify children at high risk of developing depression later in life. [More]
Amorphous iron nanoparticles have potential to kill tumor cells

Amorphous iron nanoparticles have potential to kill tumor cells

Amorphous iron nanoparticles have a specific toxicity in tumor cells. In the journal Angewandte Chemie, Chinese scientists describe their design and synthesis of a special amorphous state of nanoparticulate iron, which can locally release reactive iron species in the acidic and hydrogen peroxide rich environment of cancer cells, providing new possibilities for theranostics and chemodynamic therapies. [More]
Pioneer calls on electrophysiologists to reexamine substrate mapping for deadly heart arrhythmia

Pioneer calls on electrophysiologists to reexamine substrate mapping for deadly heart arrhythmia

A pioneer in developing life-saving therapies for a deadly heart arrhythmia has called on electrophysiologists to reexamine a widely used technique to guide the treatment of the faulty electrical impulses responsible for these abnormal heartbeats. [More]
Optical technologies could lead to novel treatments for neurological diseases

Optical technologies could lead to novel treatments for neurological diseases

Optical technologies previously used to look at the stars in the sky will be miniaturized to look inside the brain, and could lead to new treatments for neurological diseases. [More]
New method could improve accurate diagnosis of ovarian cancer before surgery

New method could improve accurate diagnosis of ovarian cancer before surgery

In a landmark study, investigators from Europe propose a new and simple method to assess the risk of malignancy of women with an adnexal mass. The method identified between 89-99% of patients with ovarian cancer using the results of ultrasound examination, which can be obtained in referral and non-referral centers. [More]
Interictal discharges have neuropsychological effects in rolandic epilepsy

Interictal discharges have neuropsychological effects in rolandic epilepsy

Centrotemporal spikes experienced between seizures by children with rolandic epilepsy may disrupt functional brain networks and contribute to language, behaviour and cognitive problems, research suggests. [More]
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