Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Study assesses links between early negative life events, orbitofrontal cortical thickness and depression in young adults

Study found that early negative life events predict depressive symptoms in young adulthood, but not through accelerated thinning of the orbitofrontal cortex (OFC) across adolescence, challenging previous assumptions about the brain's structural changes and mental health.

10 Dec 2023

Novel TMS protocol shows promise for treating hard-to-treat depression

By making slight modifications to an already approved brain stimulation technique called transcranial magnetic stimulation (TMS), researchers have reported profound improvement in patients with hard-to-treat depression.

29 Nov 2023

Science tackles mental health: New tools against anxiety and depression in a stressed world

This review in the Proceedings of the National Academy of Sciences discusses the role of scientific tools in combating mental health disorders like anxiety, MDD, and PTSD, emphasizing the need for a deep scientific understanding and diverse treatment approaches in the face of a global surge in psychological stress. The study explores stress biology, treatment strategies, and the importance of personalized scientific approaches to effectively address the mental health crisis.

29 Nov 2023

The potential of polyunsaturated fatty acids in alleviating depression and reducing suicide risk

Research in 'Molecular Psychiatry' explores the role of long-chain polyunsaturated fatty acids (LC-PUFAs) in major depressive disorder (MDD) and suicide risk, showing mixed results in clinical trials for depression treatment. The study underscores the need for further investigation into LC-PUFAs' neurobiology to advance personalized medicine for mood disorders and suicide prevention.

26 Nov 2023

A review of automated clinical depression diagnosis tools

A review on how the latest computational methods that utilize facial, acoustic, and semantic features are being deployed to predict major depressive disorders.

23 Nov 2023

Significant genetic variations linked to cannabis use disorder identified in major global ancestries

Multi-ancestry genome-wide association study of cannabis use disorder.

22 Nov 2023

Precision TMS approach yields improved outcomes for patients with major depressive symptoms

A new study from UCLA Health researchers demonstrates that a novel treatment is effective in most patients with major depressive symptoms even after multiple failed courses of antidepressant medication.

20 Nov 2023

Novel antidepressant zuranolone effective in alleviating depression and anxiety symptoms

The efficacy and safety of zuranolone in treating major depressive disorder (MDD).

20 Nov 2023

Eating disorder claim lines increase significantly from 2018 to 2022

From 2018 to 2022, eating disorder claim lines increased 65 percent nationally as a percentage of all medical claim lines.

15 Nov 2023

Transforming brain research with AI and machine learning

Using machine learning, researchers are able to use data from the brain to glean deeper insights and apply this new knowledge in clinical settings.

13 Nov 2023

Study shows depression increases disability risk in rheumatoid arthritis sufferers

The interactions between rheumatoid arthritis (RA) and major depressive disorder (MDD).

7 Nov 2023

Study unveils the neurobiological underpinnings of adolescent major depressive disorder

Published in the 2023 Volume 3 issue of Psychoradiology a team of dedicated researchers from South China Normal University delved deep into the unique brain network dysfunctions present in adolescents with MDD.

3 Nov 2023

LHPP gene identified as a potential target for treatment-resistant depression

Major depressive disorder (MDD) is a widespread mental health condition that for many is disabling. It has long been appreciated that MDD has genetic as well as environmental influences.

2 Nov 2023

Can metabolic biomarkers help distinguish between depressive episodes of bipolar disorder and major depressive disorder?

Researchers identify metabolomic biomarkers from dried blood spots that can distinguish between depressive episodes in major depressive disorder and bipolar disorder. The study enhances diagnostic accuracy, particularly when traditional psychiatric assessments are inconclusive.

26 Oct 2023

Heated yoga sessions linked to greater reductions in depressive symptoms

In a randomized controlled clinical trial of adults with moderate-to-severe depression, those who participated in heated yoga sessions experienced significantly greater reductions in depressive symptoms compared with a control group.

24 Oct 2023

Pupil size may predict response to TMS treatment for depression

New findings from researchers at UCLA Health suggest that measuring changes in how pupils react to light could help predict recovery from depression and personalize transcranial magnetic stimulation (TMS) treatment of major depressive disorder.

20 Oct 2023

Study sheds light on genetic architecture of postpartum depression

Postpartum depression (PPD), a common subtype of major depressive disorder, is more heritable than other psychiatric conditions, yet the genetics of PPD are understudied compared to these other psychiatric conditions., such as anxiety and bipolar disorder.

19 Oct 2023

Major Depressive Disorder News and Research

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