Medicinal Chemistry News and Research

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Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances.

13 Apr 2024

New drug candidates show promise to reverse HIV immune evasion

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

19 Mar 2024

New compounds show potential to mimic benefits of exercise

Doctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exercise.

18 Mar 2024

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Researchers develop precise drugs to target HIV's Nef protein

A team of University of Michigan researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.

9 Mar 2024

U-M research offers a new path forward in the development of anti-HIV drugs

A team of University of Michigan researchers has successfully modified a naturally occurring chemical compound in the lab, resulting in advanced lead compounds with anti-HIV activity.

8 Mar 2024

Rare gene mutations in hereditary Alzheimer's disease disrupt amyloid production, study shows

A University of Kansas study of rare gene mutations that cause hereditary Alzheimer's disease shows these mutations disrupt production of a small sticky protein called amyloid.

29 Feb 2024

UB research may offer a more streamlined approach to developing cancer drugs

Drug discovery can be a frustrating process of trial and error.

28 Feb 2024

SCIEX’s Jose Castro-Perez Reveals How They're Setting New Standards in Mass Spectrometry

SCIEX’s Reveals How They're Setting New Standards in Mass Spectrometry at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 22 Feb 2024

Scientists develop 3D-printable gelatin materials for reconstructive and plastic surgery

Researchers from IOCB Prague and Ghent University have been working on improving the properties of gelatin-based materials, thereby expanding the possibilities of their use mainly in medicine.

21 Feb 2024

Researchers introduce a pioneering approach to combat neurodegenerative diseases

Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis (ALS).

16 Feb 2024

Moffitt researchers develop novel reagent for efficient synthesis of sulfur-containing drug candidates

During the past decade, there has been significant development of new sulfur containing compounds that are used in various industries, including pharmaceuticals and agricultural products.

22 Jan 2024

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications journal focusing on critical studies about molecular structure and biological activity, has published the company's discovery of a novel PHD inhibitor for the treatment of anemia.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Medicinal Chemistry News and Research

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

New drug candidates show promise to reverse HIV immune evasion

New compounds show potential to mimic benefits of exercise

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Researchers develop precise drugs to target HIV's Nef protein

U-M research offers a new path forward in the development of anti-HIV drugs

Rare gene mutations in hereditary Alzheimer's disease disrupt amyloid production, study shows

UB research may offer a more streamlined approach to developing cancer drugs

SCIEX’s Jose Castro-Perez Reveals How They're Setting New Standards in Mass Spectrometry

Scientists develop 3D-printable gelatin materials for reconstructive and plastic surgery

Researchers introduce a pioneering approach to combat neurodegenerative diseases

Moffitt researchers develop novel reagent for efficient synthesis of sulfur-containing drug candidates

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

New targeted therapy eliminates cancer with zero side effects

New synthetic antibiotic found to be more effective than established drugs against 'superbugs'

Natural compound activates macrophages to fight resistant tuberculosis bacteria

DeepMirror launches early access programme for its intuitive molecular drug design software

Small molecule drug shows promise as potential new treatment for multiple sclerosis

TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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