Medulloblastoma News and Research

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Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.

13 Mar 2024

Research project receives 25 million U.S. dollars to develop drugs against childhood cancers

Cancer is one of the most common causes of death in children worldwide. A research team in which the University of Würzburg is involved wants to change this – and has now received substantial funding for its work.

6 Mar 2024

Air quality and residential greenness influence childhood cancer development

In a new study led by the University of Minnesota's Masonic Cancer Center and the U of M Medical School, researchers found that exposure to air pollution and vegetation may impact childhood cancer development.

21 Feb 2024

Research potentially expands options for patients with aggressive childhood cancer

Research is shedding light and potentially expanding options for patients living with Medulloblastoma, an aggressive childhood cancer.

8 Jan 2024

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

4 Jan 2024

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA-;loops of DNA found outside of regular chromosomes-;are twice as likely to relapse and three times as likely to die within five years of diagnosis.

14 Nov 2023

NIH awards $3.2 million to study how unique DNA circles drive deadly pediatric brain tumors

Lukas Chavez, Ph.D., has received $3.2 million from the National Institutes of Health to study how unique DNA circles found in cancer cells drive deadly pediatric brain tumors.

14 Sep 2023

Researchers develop new method to find mutations in pediatric brain tumors

Researchers at Uppsala university have developed a new method to find mutations in brain tumors in children.

7 Aug 2023

2023 PCRF grant recipients announced for exploring new, safer treatments for pediatric cancers

The Pediatric Cancer Research Foundation, a nonproﬁt focused on transforming pediatric cancer care by accelerating research breakthroughs, today announced the 19 recipients of its 2023 research grants.

26 May 2023

Novel immunotherapy appears to be safe, well tolerated by children with relapsed brain tumors

The first in-human-study of a new immunotherapy that blocks a natural enzyme tumors commandeer for their protection was well tolerated by children with relapsed brain tumors and enabled many to have unexpected months of a more normal life, researchers say.

25 Apr 2023

Using a long-read approach to gain better understanding of DNA mutations in cancer genomes

Looking to learn more from genomics sequencing about DNA mutations and cancer, researchers applied a long-read approach to get a broader genomic view.

27 Mar 2023

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

6 Mar 2023

New way to carry drugs across the blood-brain barrier using nanoparticles

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Definition of low-risk WNT-pathway medulloblastoma may need to be refined, say experts

A new research perspective was published in Oncotarget's Volume 14 on February 7, 2023, entitled, "WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go?"

27 Feb 2023

New drug combination may offer better prognosis for children diagnosed with deadly brain cancer

Researchers at the University of Colorado Anschutz Medical Campus have discovered a drug combination that may offer a better prognosis for children diagnosed with MYC amplified Medulloblastoma, an often deadly form of brain cancer.

13 Jan 2023

Georgia State brain researcher receives NIH grant to create a model for personalized cancer treatments

A brain researcher at Georgia State University has been awarded a five-year, $3.06 million grant from the National Cancer Institute at the National Institutes of Health to create a model for personalized cancer treatments.

8 Dec 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Enzyme that drives growth of medulloblastoma may hold the key to future treatment

An enzyme that drives the growth of an often-lethal childhood brain cancer may hold the key to a future treatment, says a McMaster University-led study.

10 Nov 2022

Researchers identify gene expression correlated with response to chemotherapy in medulloblastomas

An international team led by the Department of Neurosurgery, Niigata University, has identified a new gene called Schlafen11 (SLFN11) whose expression is tightly correlated with response to chemotherapy in medulloblastomas, a highly malignant brain tumor affecting pediatric, adolescent, and young adult populations.

7 Nov 2022

New research lays the foundation for more effectively treating pediatric brain tumor

In a ground-breaking new study, scientists have uncovered the mechanics of the blood-tumor barrier, one of the most significant obstacles to improving treatment efficacy and preventing the return of cancerous cells.

1 Nov 2022