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Experimental drug shows promise for stopping melanoma and other forms of cancer

Experimental drug shows promise for stopping melanoma and other forms of cancer

An experimental cancer drug works differently than intended and shows significant promise for stopping melanoma and possibly other forms of cancer, research from the University of Virginia School of Medicine suggests. [More]
Researcher identifies mechanisms that may cause resistance to BRAF inhibitor

Researcher identifies mechanisms that may cause resistance to BRAF inhibitor

BRAF mutation occurs in between 40% and 50% of metastasising melanomas (skin cancers), boosting tumour growth. [More]
UCI molecular biologists find new way to combat skin cancer

UCI molecular biologists find new way to combat skin cancer

Using new and innovative immune-therapeutic approaches to silence "don't eat me" signaling proteins recognized by specialized cells of the immune system, University of California, Irvine molecular biologists and their colleagues have identified an effective way to combat metastatic melanoma. [More]
PCP screening could be effective way to improve early melanoma diagnosis

PCP screening could be effective way to improve early melanoma diagnosis

Skin cancer screenings performed by primary care physicians (PCPs) during routine office visits improve the detection of potentially deadly melanomas and find them in earlier stages, according to new research from the University of Pittsburgh School of Medicine. [More]
Using proteomic mass spectrometry imaging to detect malignant melanoma: an interview with Stephen Turner

Using proteomic mass spectrometry imaging to detect malignant melanoma: an interview with Stephen Turner

Today, using anatomic pathology, the differences in appearance of a normal or a malignant lesion can be difficult to tell when just using light microscopy. [More]
Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Oncologists at the Fred Hutchinson Cancer Research Center have successfully treated a patient with metastatic melanoma by combining two different types of immunotherapy. Cassian Yee and colleagues describe their approach in a paper, "Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient," that will be published online May 30 in The Journal of Experimental Medicine. [More]
Malicious form of ATF2 protein drives formation of melanoma

Malicious form of ATF2 protein drives formation of melanoma

An international collaborative study led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a malicious form of a protein that drives the formation of melanoma. [More]
Protea signs license agreement with Yale to develop new technology for detecting malignant melanoma

Protea signs license agreement with Yale to develop new technology for detecting malignant melanoma

Protea Biosciences Group, Inc. announced today that it had entered into an exclusive license agreement with Yale University for new technology to improve the differential diagnosis of malignant melanoma. [More]
Mouse model can help identify new, more effective melanoma-preventing agents

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD. [More]
Scientists reveal mechanism involved in regulation of lymphangiogenesis

Scientists reveal mechanism involved in regulation of lymphangiogenesis

After an injury to tissues, such as in organ transplantation, the body grows new lymphatic vessels in a process known as lymphangiogenesis. A new study in Nature Communications reveals a mechanism involved in the regulation of this process, specifically in corneal transplants and infectious eye disease. [More]
Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation. [More]
Smartphone microscopes could improve detection of skin cancer in developing countries

Smartphone microscopes could improve detection of skin cancer in developing countries

Everyone knows smartphones can be used as calendars, calculators, radios and cameras. But, did you know they can also be used as microscopes that have the potential to save lives? They are called smartphone microscopes and dermatologists at The University of Texas Health Science Center at Houston think these devices could improve the detection of skin cancer in developing countries. [More]
HIV drug could delay drug resistance, making skin cancer treatment effective for longer time

HIV drug could delay drug resistance, making skin cancer treatment effective for longer time

An HIV drug could stop one of the early changes in skin cancer cells that leads to them becoming resistant to treatment, according to a Cancer Research UK-funded study published in Cancer Cell today [More]
Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

A research team of the Comprehensive Cancer Center of MedUni Vienna and AKH Vienna was able to demonstrate that a therapy change in the area of metastasising renal cell carcinoma significantly increases the life average expectancy and clearly improves the compatibility of the therapy. [More]
Specialized tests can help dermatologists provide individualized care for melanoma patients

Specialized tests can help dermatologists provide individualized care for melanoma patients

Melanoma rates in the United States have doubled over the past two decades.1 Fortunately for patients, this increase in melanoma incidence has been accompanied by the development of more effective tools for diagnosis and treatment, including genetic and molecular testing. [More]
Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

A study by J. William Harbour, M.D., associate director for Basic Research and leader of the Eye Cancer Site Disease Group at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and colleagues published today in Clinical Cancer Research details the discovery of a biomarker that puts patients at a higher risk for metastasis of uveal melanoma. [More]
Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced it will offer clinical laboratory testing using the PD-L1 IHC 28-8 pharmDx qualitative test from Dako, an Agilent Technologies company. [More]
Wistar Institute scientists use revolutionary method to block melanoma progression

Wistar Institute scientists use revolutionary method to block melanoma progression

Melanoma patients who receive treatment with targeted therapies experience an initial response that feels like a cure, but that early excitement is quickly dampened when patients relapse as their cancers find alternative pathways in our cells to grow and spread. With melanoma so good at escaping targeted treatments, there's a dire need to halt these cancers in their tracks to prolong good responses and promote longer, healthier lives. [More]
New oral breast cancer drug has potential to combat other types of cancer

New oral breast cancer drug has potential to combat other types of cancer

Palbociclib, a new oral drug whose efficacy in combating breast cancer has been demonstrated alone and in combination with endocrine therapy, also has potential to combat other types of cancer, according to a literature review and additional original research conducted by experts at the Abramson Cancer Center in the University of Pennsylvania published this month in JAMA Oncology. [More]
New three-drug delivery system shows promise for treatment of metastatic melanoma

New three-drug delivery system shows promise for treatment of metastatic melanoma

Researchers have developed a new three-drug delivery system for cancer treatment, especially metastatic melanoma, the deadliest form of skin cancer - and shown that the system may have particular value with cancers like this that often spread through the lymphatic system. [More]
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