Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

CGRP antagonists and dietary changes show promise for migraine treatment

Review in "Medicina" explores advancements in migraine therapy, highlighting the role of CGRP antagonists and dietary interventions like ketogenic and low-glycemic diets in reducing migraine frequency and severity.

17 Jan 2024

New study finds maternal vaccine and monoclonal antibody effective against RSV in infants

The impact and cost-effectiveness of maternal vaccination (MV) to long-acting monoclonal antibody (la-mAB) therapy.

10 Jan 2024

New Omicron subvariants test vaccine limits, reveal unique infection challenges

Study reveals that the Omicron subvariants BA.2.86 and FLip show unique mutations and infectivity profiles, with BA.2.86 being highly infectious and resistant to most conventional antibodies, underscoring the need for updated vaccines.

9 Jan 2024

SARS-CoV-2 BA.2.86 shows increased lung targeting despite vaccine effectiveness

New research shows that the recently emerged BA.2.86 omicron subvariant of the virus that causes COVID-19 can be neutralized by bivalent mRNA vaccine-induced antibodies in the blood, which explains why this variant did not cause a widespread surge as previously feared.

8 Jan 2024

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

Study presents a new SARS-CoV-2 S2 subunit vaccine that elicits strong antibody responses against various sarbecovirus strains, including challenging variants like XBB.1.5, demonstrating its potential as a broadly effective and stable vaccine option.

18 Dec 2023

Antibody treatment shields transplant patients against COVID-19

New research from Cedars-Sinai's Comprehensive Transplant Center found that a monoclonal antibody treatment reduced the risk of COVID-19 in a large group of solid organ transplant patients who were administered the drug as a preventive measure against the disease.

18 Dec 2023

Small molecule applications of process Raman spectroscopy

In this interview, Kevin Broadbelt of Thermo Fisher Scientific discusses the small molecule applications of process Raman spectroscopy.

From Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy 11 Dec 2023

Promising candidate medication for preventing and reversing fentanyl-induced overdose

Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis.

7 Dec 2023

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Researchers have discovered the novel mechanism that underlies a previously reported observation that infection by group A Streptococcus bacteria reduces the risk of later developing Type 1 diabetes.

5 Dec 2023

Survey: Over a third of Americans worry about the "tripledemic" of respiratory illnesses

Over a third of American adults are worried that they or someone in their family will get the seasonal flu, Covid-19, or RSV (respiratory syncytial virus) in the next three months, according to a new health survey from the Annenberg Public Policy Center (APPC) of the University of Pennsylvania.

20 Nov 2023

B-BiTE modality enhances anti-myeloma effects of clinically available antibodies

Multiple myeloma still appears to be an incurable hematological malignancy. One of the reasons is that myeloma cells can be heterogenous and acquire resistance after anti-myeloma treatment.

16 Nov 2023

Gene splicing determines CD20 levels and response to monoclonal antibody therapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

16 Nov 2023

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

The frequency of viral rebound (VR) among acute coronavirus disease 2019 patients.

16 Nov 2023

Fecal microbiota transplantation boosts survival in metastatic colorectal cancer treatment

A recent study in eClinicalMedicine found that fecal microbiota transplantation, combined with fruquintinib and tislelizumab, significantly improved survival rates in patients with microsatellite stable metastatic colorectal cancer, showing manageable safety and notable increases in progression-free and overall survival.

15 Nov 2023

Abelacimab significantly reduces bleeding risk in atrial fibrillation patients with stroke risk

An experimental anti-clotting medication, abelacimab, significantly reduced bleeding among people with atrial fibrillation (or AFib) who were at risk of stroke, according to results of the AZALEA-TIMI 71 trial, presented today as late-breaking science at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

New hope for preventing preterm births: IL-6R blockade reduces neonatal mortality

The role of interleukin (IL)-6 and IL-1α in sterile intraamniotic inflammation (SIAI), a condition associated with preterm birth (PTB).

9 Nov 2023

A new RSV shot could help protect babies this winter — if they can get it in time

Emily Bendt was in her third trimester of pregnancy when she first heard the Centers for Disease Control and Prevention had approved a new shot for infants to protect them from the respiratory syncytial virus, or RSV.

9 Nov 2023

Monoclonal Antibody News and Research

Further Reading

CGRP antagonists and dietary changes show promise for migraine treatment

New study finds maternal vaccine and monoclonal antibody effective against RSV in infants

New Omicron subvariants test vaccine limits, reveal unique infection challenges

SARS-CoV-2 BA.2.86 shows increased lung targeting despite vaccine effectiveness

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

Antibody treatment shields transplant patients against COVID-19

Small molecule applications of process Raman spectroscopy

Promising candidate medication for preventing and reversing fentanyl-induced overdose

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Survey: Over a third of Americans worry about the "tripledemic" of respiratory illnesses

B-BiTE modality enhances anti-myeloma effects of clinically available antibodies

Gene splicing determines CD20 levels and response to monoclonal antibody therapy

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

Fecal microbiota transplantation boosts survival in metastatic colorectal cancer treatment

Abelacimab significantly reduces bleeding risk in atrial fibrillation patients with stroke risk

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Tumor-immune interactions predict treatment responses in multiple myeloma

New hope for preventing preterm births: IL-6R blockade reduces neonatal mortality

A new RSV shot could help protect babies this winter — if they can get it in time

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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